公开(公告)号：US20090211976A1

公开(公告)日：2009-08-27

申请号：US12436343

申请日：2009-05-06

申请人： Dietrich SEIDEL ,  Karl-Siegfried BOOS

发明人： Dietrich SEIDEL ,  Karl-Siegfried BOOS

IPC分类号： B01D15/00 ,  B01D15/04

CPC分类号： B01D61/00 ,  A61M1/3679 ,  A61M2202/203 ,  B01D67/0093 ,  B01D69/08 ,  B01D71/56 ,  B01D71/82 ,  B01D2323/38 ,  A61M2202/0057

摘要： A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.

公开(公告)号：US4935204A

公开(公告)日：1990-06-19

申请号：US271368

申请日：1988-11-14

申请人： Dietrich Seidel ,  Wolfgang Feller ,  Gerhard Rosskopf

发明人： Dietrich Seidel ,  Wolfgang Feller ,  Gerhard Rosskopf

IPC分类号： C08B37/10 ,  A61K35/14 ,  A61K35/16 ,  A61M1/36

CPC分类号： A61M1/3679 ,  A61M1/3675 ,  Y10S435/803 ,  Y10S514/822 ,  Y10S514/833

摘要： A process for the specific adsorption of heparin and other heparin-like substances which comprises flowing a buffered solution of whole blood, from which corpuscular blood constituents have been removed, plasma and/or solutions containing whole blood or plasma through an adsorber capsule containing a medium that adsorbs heparin and other heparin-like substances at an acid pH, preferably in the range of 4.0 to 5.5. Preferably, the process is carried out in a closed, extracorporeal circulation and the medium possesses anion exchange resin properties.

摘要翻译： 一种用于特异性吸附肝素和其他肝素样物质的方法，其包括将已经去除血球成分的全血缓冲溶液流经血浆和/或含有全血或血浆的溶液通过含有介质的吸附剂胶囊 其在酸性pH下吸附肝素和其他类肝素物质，优选在4.0至5.5的范围内。 优选地，该方法在闭合的体外循环中进行，并且该介质具有阴离子交换树脂性质。

公开(公告)号：US4908354A

公开(公告)日：1990-03-13

申请号：US124394

申请日：1987-11-20

申请人： Dietrich Seidel ,  Heinrich Wieland ,  Gerhard Rosskopf ,  Wolfgang Feller

发明人： Dietrich Seidel ,  Heinrich Wieland ,  Gerhard Rosskopf ,  Wolfgang Feller

IPC分类号： C08B37/10 ,  A61K35/14 ,  A61K35/16 ,  A61M1/36

CPC分类号： A61M1/3687 ,  A61M2202/046

摘要： A method of precipitating low-density lipoproteins which comprises administering to a volume of blood, plasma or solutions containing blood or plasma a therapeutically or diagnostically effective amount of a low-density lipoprotein precipitating substance at an acid pH such that an anticoagulent effect associated with heparin is minimized or eliminated. The substances utilized in such a method include hydrolyzed heparin, hydrolyzed heparin acylated at free amine groups, sulfated glycosamino glycan and sulfated polysaccharides.

摘要翻译： 一种沉淀低密度脂蛋白的方法，其包括给予一定体积的血液，血浆或含有血液或血浆的溶液，治疗或诊断有效量的酸性pH下的低密度脂蛋白沉淀物质，使得与肝素相关的抗凝血作用 被最小化或消除。 在这种方法中使用的物质包括水解的肝素，游离胺基酰化的水解肝素，硫酸化糖胺基聚糖和硫酸化多糖。

公开(公告)号：US4298441A

公开(公告)日：1981-11-03

申请号：US159672

申请日：1980-06-16

申请人： Dietrich Seidel ,  Heinrich Wieland ,  Ewald Molinari

发明人： Dietrich Seidel ,  Heinrich Wieland ,  Ewald Molinari

IPC分类号： G01N33/92 ,  G01N33/96 ,  G01N27/26

CPC分类号： G01N33/96 ,  G01N33/92 ,  G01N2800/044

摘要： A method of preserving the electrophoretic properties of lipoproteins in human or animal plasma, plasma fractions or sera, in which the lipoprotein pattern is to be electrophoretically determined, consists in that non-reducing sugars are added to the plasma, plasma fractions or sera, the mixture is lyophilized and the lyophilizate is reconstituted prior to determination.

摘要翻译： 在血浆，血浆级分或血清中维持脂蛋白的电泳性质的方法，其中脂蛋白模式将被电泳确定，其方法在于将非还原糖加入到血浆，血浆级分或血清中， 将混合物冻干，并在测定前重构冻干物。

公开(公告)号：US09012137B2

公开(公告)日：2015-04-21

申请号：US13003859

申请日：2009-07-23

申请人： Dietrich Seidel

发明人： Dietrich Seidel

IPC分类号： G01N31/00 ,  C12Q1/00 ,  G01N33/80

CPC分类号： G01N33/80 ,  Y10T436/10

摘要： The present invention refers to a method of processing a biological fluid which comprises cellular components by a freezing/thawing treatment. The method is particularly useful for preparing biological samples for analyte detection.

摘要翻译： 本发明涉及通过冷冻/解冻处理包括细胞成分的生物流体的处理方法。 该方法对于制备用于分析物检测的生物样品特别有用。

公开(公告)号：US08231838B2

公开(公告)日：2012-07-31

申请号：US12858760

申请日：2010-08-18

申请人： Dietrich Seidel

发明人： Dietrich Seidel

IPC分类号： A61L2/04

CPC分类号： G01N33/80 ,  G01N1/44 ,  G01N33/9493 ,  G01N33/96 ,  Y10T436/107497 ,  Y10T436/25

摘要： The present invention refers to a method of processing a biological fluid which comprises cellular components by heat treatment. The method is particularly useful for preparing biological samples for analyte detection. Further, the invention refers to a processed biological fluid comprising substantially quantitatively disintegrated cellular components.

摘要翻译： 本发明涉及通过热处理包括细胞成分的生物流体的处理方法。 该方法对于制备用于分析物检测的生物样品特别有用。 此外，本发明涉及包含基本上定量分解的细胞组分的经处理的生物流体。

公开(公告)号：US20100311153A1

公开(公告)日：2010-12-09

申请号：US12858760

申请日：2010-08-18

申请人： Dietrich SEIDEL

发明人： Dietrich SEIDEL

IPC分类号： C12M3/00

CPC分类号： G01N33/80 ,  G01N1/44 ,  G01N33/9493 ,  G01N33/96 ,  Y10T436/107497 ,  Y10T436/25

摘要： The present invention refers to a method of processing a biological fluid which comprises cellular components by heat treatment. The method is particularly useful for preparing biological samples for analyte detection. Further, the invention refers to a processed biological fluid comprising substantially quantitatively disintegrated cellular components.

摘要翻译： 本发明涉及通过热处理包括细胞成分的生物流体的处理方法。 该方法对于制备用于分析物检测的生物样品特别有用。 此外，本发明涉及包含基本上定量分解的细胞组分的经处理的生物流体。

公开(公告)号：US07709644B2

公开(公告)日：2010-05-04

申请号：US11651309

申请日：2007-01-09

申请人： Herbert Diehl ,  Andreas Krebs ,  Elvira Krebs, legal representative ,  Walter Lange ,  Hanns-Ingolf Paul ,  Dietrich Seidel ,  Rolf Grosser ,  Tobias Reichelt

发明人： Herbert Diehl ,  Andreas Krebs ,  Walter Lange ,  Hanns-Ingolf Paul ,  Dietrich Seidel ,  Rolf Grosser ,  Tobias Reichelt

IPC分类号： C07D487/04

CPC分类号： C07D471/04 ,  C07B2200/07

摘要： The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed).In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.

摘要翻译： 本发明涉及顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映体富集的方法，借助于连续逆流色谱法，其也被描述为SMB色谱法 （SMB =模拟移动床）。 另一方面，本发明涉及使用上述方法制备（1S，6R）-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷的方法，该方法还包括 外消旋化步骤

公开(公告)号：US20050009001A1

公开(公告)日：2005-01-13

申请号：US10860786

申请日：2004-06-03

申请人： Dietrich Seidel ,  Karl-Siegfried Boos

发明人： Dietrich Seidel ,  Karl-Siegfried Boos

IPC分类号： A61M1/36 ,  B01D61/00 ,  B01D67/00 ,  B01D69/08 ,  B01D71/56 ,  B01D71/82 ,  A01N1/02 ,  A61M31/00 ,  C02F1/44

CPC分类号： B01D61/00 ,  A61M1/3679 ,  A61M2202/203 ,  B01D67/0093 ,  B01D69/08 ,  B01D71/56 ,  B01D71/82 ,  B01D2323/38 ,  A61M2202/0057

摘要： A device for removing bacterial lipopolysaccharides and lipoteichoic acids from blood or plasma in an extracorporeal perfusion system contains, in a housing that can be incorporated into the perfusion system, a hollow fiber material that is suitable for the selective removal of bacterial lipopolysaccharides and lipoteichoic acids, the device being arranged in such a way that the blood or plasma entering through a first opening of the housing must pass through the hollow fiber material before it leaves through a second opening of the housing and is directed to the rest of the perfusion circuit.

摘要翻译： 用于在体外灌注系统中从血液或血浆中除去细菌脂多糖和脂磷壁酸的装置在可并入灌注系统的壳体中含有适于选择性除去细菌脂多糖和脂磷壁酸的中空纤维材料， 所述装置被布置成使得通过所述壳体的第一开口进入的血液或等离子体在通过所述壳体的第二开口之前必须通过所述中空纤维材料，并被引导到所述灌注回路的其余部分。

公开(公告)号：US5846426A

公开(公告)日：1998-12-08

申请号：US720925

申请日：1996-10-07

申请人： Karl-Siegfried Boos ,  Dietrich Seidel ,  Klaus Spengler ,  Gudrun Henke ,  Andreas Rauh

发明人： Karl-Siegfried Boos ,  Dietrich Seidel ,  Klaus Spengler ,  Gudrun Henke ,  Andreas Rauh

IPC分类号： A61M1/34 ,  A61M1/36 ,  B01D15/00 ,  B01J20/02 ,  B01J20/10 ,  B01J20/22 ,  B01J20/32 ,  B01D15/08 ,  C08B37/00

CPC分类号： B01D15/00 ,  A61M1/3679 ,  B01J20/223 ,  B01J20/286 ,  B01J20/3078 ,  B01J20/3092 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3265 ,  A61M1/34 ,  B01J2220/54 ,  B01J2220/58

摘要： The present invention concerns the use of an adsorbent material modified with polynuclear metal oxyhydroxides for the selective elimination of inorganic phosphate from liquids, in particular from body fluids containing protein such as whole blood, plasma, liquid contents of the intestine as well as from dialysis fluid, as well as a process for the production of a pharmaceutical agent for oral application for the selective removal of inorganic phosphate in which an adsorbent material used according to the present invention, as such or pressed into powder form, is coated with a layer resistant to gastric acid or dispensed into an acid-resistant capsule. In order to selectively eliminate inorganic phosphate in an extracorporeal perfusion system, a body fluid such as whole blood or plasma is passed over one of the adsorbent materials.

摘要翻译： 本发明涉及用多核金属羟基氧化物改性的吸附材料用于从液体中选择性地除去无机磷酸盐的用途，特别是从含有蛋白质如全血，血浆，肠液的液体以及透析液 以及用于生产用于选择性除去无机磷酸酯的口服应用药物的方法，其中根据本发明使用的吸附剂材料本身或压制成粉末形式的涂层具有耐受 胃酸或分配到耐酸胶囊中。 为了选择性地消除体外灌注系统中的无机磷酸盐，诸如全血或血浆的体液通过一种吸附材料。