Gilvocarcin gene cluster, recombinant production and use thereof
    3.
    发明授权
    Gilvocarcin gene cluster, recombinant production and use thereof 失效
    Gilvocarcin基因簇,重组生产和使用

    公开(公告)号:US07799904B2

    公开(公告)日:2010-09-21

    申请号:US10866089

    申请日:2004-06-14

    CPC分类号: C12N15/52

    摘要: A nucleic acid molecule encoding the gilvocarcin V gene cluster and subunits thereof. Recombinant vectors and host cells comprising a nucleic acid compound encoding the gilvocarcin V gene cluster or subunits thereof. Host cells comprising recombinant vectors encoding the gilvocarcin polyketide synthase and gilvocarcin post-PKS modifying enzymes from Streptomyces griseoflavus can be used to produce gilvocarcin and functional gilvocarcin mutants, analogs and derivatives thereof with application as antibiotics, anticancer agents, immunosuppressants, antivirals, and neuroprotective agents.

    摘要翻译: 编码gvvocarcin V基因簇的核酸分子及其亚单位。 重组载体和宿主细胞,其包含编码gvvocarcin V基因簇或其亚基的核酸化合物。 包含重组载体的宿主细胞可以使用来自灰黄链霉菌(Streptomyces grisoflavus)的编码戈非卡因聚酮化合物合成酶和gilvocarcin后PKS修饰酶的重组载体,其用作抗生素,抗癌剂,免疫抑制剂,抗病毒剂和神经保护剂,可用于产生gilvocarcin和功能性gilvocarcin突变体,其类似物和衍生物 。

    Gilvocarcin gene cluster, recombinant production and use thereof
    4.
    发明申请
    Gilvocarcin gene cluster, recombinant production and use thereof 失效
    Gilvocarcin基因簇,重组生产和使用

    公开(公告)号:US20050048536A1

    公开(公告)日:2005-03-03

    申请号:US10866089

    申请日:2004-06-14

    CPC分类号: C12N15/52

    摘要: A nucleic acid molecule encoding the gilvocarcin V gene cluster and subunits thereof. Recombinant vectors and host cells comprising a nucleic acid compound encoding the gilvocarcin V gene cluster or subunits thereof. Host cells comprising recombinant vectors encoding the gilvocarcin polyketide synthase and gilvocarcin post-PKS modifying enzymes from Streptomyces griseoflavus can be used to produce gilvocarcin and functional gilvocarcin mutants, analogs and derivatives thereof with application as antibiotics, anticancer agents, immunosuppressants, antivirals, and neuroprotective agents.

    摘要翻译: 编码gvvocarcin V基因簇的核酸分子及其亚单位。 重组载体和宿主细胞,其包含编码gvvocarcin V基因簇或其亚基的核酸化合物。 包含重组载体的宿主细胞可以使用来自灰黄链霉菌(Streptomyces grisoflavus)的编码戈非卡因聚酮化合物合成酶和gilvocarcin后PKS修饰酶的重组载体,其用作抗生素,抗癌剂,免疫抑制剂,抗病毒剂和神经保护剂,可用于产生gilvocarcin和功能性gilvocarcin突变体,其类似物和衍生物 。