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1.发明申请Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 有权编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US20050063981A1
公开(公告)日：2005-03-24
申请号：US10729340
申请日：2003-12-04
申请人： Dirk Jager , Elisabeth Stockert , Barry Picker , Matthew Scanlan , Cynthia Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
发明人： Dirk Jager , Elisabeth Stockert , Barry Picker , Matthew Scanlan , Cynthia Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
CPC分类号： C07K14/47 , C07K14/4748
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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2.发明申请Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof 有权编码癌症相关抗原的分离的核酸分子，每个SE的抗原及其用途公开(公告)号：US20090203123A1
公开(公告)日：2009-08-13
申请号：US12011953
申请日：2008-01-30
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen , Barry C. Picker , Cynthia H. Scanlan
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen , Barry C. Picker , Cynthia H. Scanlan
CPC分类号： C07K14/47 , C07K14/4748
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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3.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 有权编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US07622568B2
公开(公告)日：2009-11-24
申请号：US11985028
申请日：2007-11-12
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
IPC分类号： C07H21/02
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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4.发明申请Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US20100278850A1
公开(公告)日：2010-11-04
申请号：US12589647
申请日：2009-10-27
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
IPC分类号： A61K39/00 , C07K14/435 , A61P35/00 , C07K7/06 , C07K7/08
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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公开(公告)号：US20080177031A1
公开(公告)日：2008-07-24
申请号：US11985028
申请日：2007-11-12
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
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6.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof 有权编码癌症相关抗原的分离的核酸分子，每个SE的抗原及其用途公开(公告)号：US07795409B2
公开(公告)日：2010-09-14
申请号：US12011953
申请日：2008-01-30
申请人： Dirk Jager , Elisabeth Stockert , Barry C. Picker, legal representative , Matthew Scanlan , Cynthia H. Scanlan, legal representative , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , C07K14/4748
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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7.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US08071717B2
公开(公告)日：2011-12-06
申请号：US12589647
申请日：2009-10-27
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
IPC分类号： C07K5/10
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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8.发明授权公开(公告)号：US07132507B2
公开(公告)日：2006-11-07
申请号：US10153318
申请日：2002-05-21
申请人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
发明人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
CPC分类号： C07K14/4748 , A61K39/00 , C12N2799/022 , C12N2799/023 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
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9.发明授权Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06830924B1
公开(公告)日：2004-12-14
申请号：US09270437
申请日：1999-03-16
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。 本发明还涉及关于已知分子KOC-1的观察。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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公开(公告)号：US20060089303A1
公开(公告)日：2006-04-27
申请号：US11238282
申请日：2005-09-29
申请人： Lloyd Old , Matthew Scanlan , Cynthia Scanlan , Yao-Tseng Chen
发明人： Lloyd Old , Matthew Scanlan , Cynthia Scanlan , Yao-Tseng Chen
CPC分类号： C07K14/4748 , A61K39/00 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , C07K16/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , G01N33/57407
摘要： Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more CT antigens.
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