公开(公告)号：US20050063981A1

公开(公告)日：2005-03-24

申请号：US10729340

申请日：2003-12-04

申请人： Dirk Jager ,  Elisabeth Stockert ,  Barry Picker ,  Matthew Scanlan ,  Cynthia Scanlan ,  Ali Gure ,  Elke Jager ,  Alexander Knuth ,  Lloyd Old ,  Yao-Tseng Chen

发明人： Dirk Jager ,  Elisabeth Stockert ,  Barry Picker ,  Matthew Scanlan ,  Cynthia Scanlan ,  Ali Gure ,  Elke Jager ,  Alexander Knuth ,  Lloyd Old ,  Yao-Tseng Chen

IPC分类号： C07K14/47 ,  C12Q1/68 ,  A61K39/00 ,  C07H21/04

CPC分类号： C07K14/47 ,  C07K14/4748

摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.

摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。

公开(公告)号：US20060089303A1

公开(公告)日：2006-04-27

申请号：US11238282

申请日：2005-09-29

申请人： Lloyd Old ,  Matthew Scanlan ,  Cynthia Scanlan ,  Yao-Tseng Chen

发明人： Lloyd Old ,  Matthew Scanlan ,  Cynthia Scanlan ,  Yao-Tseng Chen

IPC分类号： A61K38/17 ,  A61K38/20 ,  A61K48/00

CPC分类号： C07K14/4748 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K16/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407

摘要： Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more CT antigens.

公开(公告)号：US20060292154A1

公开(公告)日：2006-12-28

申请号：US10532489

申请日：2003-10-23

申请人： Matthew Scanlan ,  Cynthia Scanlan ,  Gerd Ritter ,  Lloyd Old ,  Achim Jungbluth

发明人： Matthew Scanlan ,  Cynthia Scanlan ,  Gerd Ritter ,  Lloyd Old ,  Achim Jungbluth

IPC分类号： G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C12N5/06 ,  C07K16/30

CPC分类号： G01N33/574 ,  C07K16/2803 ,  G01N2500/00

摘要： Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.

摘要翻译： 描述了多核苷酸分子和多肽分子A34和A33样3，以及对多肽分子A34和A33类似3的抗体。还描述了检测表达这些多肽的癌症的方法，以及用于诊断所述癌症的方法和试剂盒以及抑制方法 癌症在患者中的作用。

公开(公告)号：US20090263394A1

公开(公告)日：2009-10-22

申请号：US12378533

申请日：2009-02-17

申请人： Matthew Scanlan ,  Cynthia Scanlan ,  Gerd Ritter ,  Lioyd Old ,  Achim Jungbluth

发明人： Matthew Scanlan ,  Cynthia Scanlan ,  Gerd Ritter ,  Lioyd Old ,  Achim Jungbluth

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C07K14/435 ,  G01N33/53 ,  C12Q1/68

CPC分类号： G01N33/574 ,  C07K16/2803 ,  G01N2500/00

摘要： Polynucleotide molecules and polypeptide molecules A34 and A33-like 3 are described, as well as antibodies to polypeptide molecules A34 and A33-like 3. Also described are methods of detecting cancers expressing these polypeptides, and methods and kits for diagnosing said cancers, and methods of inhibiting effects of a cancer in a patient.

摘要翻译： 描述了多核苷酸分子和多肽分子A34和A33样3，以及对多肽分子A34和A33样3的抗体。还描述了检测表达这些多肽的癌症的方法，以及用于诊断所述癌症的方法和试剂盒，以及方法 抑制癌症在患者中的作用。