公开(公告)号：US20180110868A1

公开(公告)日：2018-04-26

申请号：US15789941

申请日：2017-10-20

申请人： Dominic P. DINOVO ,  Andrew DINOVO ,  Matthew F. SMIECHOWSKI ,  Francis H. VERHOFF

发明人： Dominic P. DINOVO ,  Andrew DINOVO ,  Matthew F. SMIECHOWSKI ,  Francis H. VERHOFF

IPC分类号： A61K47/61 ,  C12N11/10 ,  A61K36/062 ,  A61K35/74 ,  A61K38/47 ,  A61K9/00

CPC分类号： A61K47/61 ,  A61K9/0053 ,  A61K9/146 ,  A61K35/74 ,  A61K36/062 ,  A61K38/47 ,  A61K47/6921 ,  C12N11/02 ,  C12N11/06 ,  C12N11/10 ,  C12N11/14 ,  C12Y302/01017

摘要： Reactive and sorbent materials including a non-encapsulated crosslinked biological material immobilized on a support matrix that includes a polyamine and at least one support material are described. The support material can be an inorganic or organic support material. The reactive and sorbent materials are formed by reacting the biological material with the polyamine, at least one support material, and a crosslinking agent. The materials exhibit enhanced properties generally, are capable of maintaining their reactive and sorbent properties in contact with digestive fluids, and exhibiting their reactive and sorbent properties as they pass throughout an organism's entire digestive system. Reactive and sorbent materials in contact with digestive juices at pH's ranging from about 3 to about 7 have maintained their reactive and sorbent properties for at least 4 hours.