公开(公告)号：US20180142229A1

公开(公告)日：2018-05-24

申请号：US15509283

申请日：2015-09-08

申请人： Battelle Memorial Institute

发明人： Katarzyna Hanna Kucharzyk ,  Ramona Darlington ,  Ramanathan Lalgudi

IPC分类号： C12N11/04 ,  C12N11/10 ,  B09C1/10

CPC分类号： C12N11/04 ,  B09C1/10 ,  C12N11/10 ,  C12Y110/03002 ,  C12Y111/01013 ,  C12Y111/01014

摘要： An enzyme formulation includes an encapsulated fungal enzyme which is effective for degrading at least one material selected from the group consisting of hydrocarbons, vulcanized rubber, synthetic rubber, natural rubber, vulcanized polymers and perfluorinated compounds. A degradation method includes treating one of the above-mentioned materials with an encapsulated fungal enzyme to degrade the material.

公开(公告)号：US20180110868A1

公开(公告)日：2018-04-26

申请号：US15789941

申请日：2017-10-20

申请人： Dominic P. DINOVO ,  Andrew DINOVO ,  Matthew F. SMIECHOWSKI ,  Francis H. VERHOFF

发明人： Dominic P. DINOVO ,  Andrew DINOVO ,  Matthew F. SMIECHOWSKI ,  Francis H. VERHOFF

IPC分类号： A61K47/61 ,  C12N11/10 ,  A61K36/062 ,  A61K35/74 ,  A61K38/47 ,  A61K9/00

CPC分类号： A61K47/61 ,  A61K9/0053 ,  A61K9/146 ,  A61K35/74 ,  A61K36/062 ,  A61K38/47 ,  A61K47/6921 ,  C12N11/02 ,  C12N11/06 ,  C12N11/10 ,  C12N11/14 ,  C12Y302/01017

摘要： Reactive and sorbent materials including a non-encapsulated crosslinked biological material immobilized on a support matrix that includes a polyamine and at least one support material are described. The support material can be an inorganic or organic support material. The reactive and sorbent materials are formed by reacting the biological material with the polyamine, at least one support material, and a crosslinking agent. The materials exhibit enhanced properties generally, are capable of maintaining their reactive and sorbent properties in contact with digestive fluids, and exhibiting their reactive and sorbent properties as they pass throughout an organism's entire digestive system. Reactive and sorbent materials in contact with digestive juices at pH's ranging from about 3 to about 7 have maintained their reactive and sorbent properties for at least 4 hours.

公开(公告)号：US09874552B2

公开(公告)日：2018-01-23

申请号：US14870910

申请日：2015-09-30

申请人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

发明人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

IPC分类号： G01N33/50 ,  C12N5/00 ,  C12N11/10

CPC分类号： G01N33/5011 ,  C12N5/0062 ,  C12N11/10 ,  C12N2500/50 ,  G01N33/5008 ,  G01N33/5073 ,  G01N2500/10

摘要： Provided are multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer phase within an immersion aqueous polymer phase. The droplet of the droplet aqueous polymer phase contains a three-dimensional aggregate of cells (cellular spheroid). Types of cells that may be used in the multi-phases system include stem cells and cancer cells. The cellular spheroids with the multi-phase system may be used to monitor cell growth in three-dimensional systems, or screen drugs in a three-dimension aggregate of cells.

公开(公告)号：US20170226500A1

公开(公告)日：2017-08-10

申请号：US15326519

申请日：2015-07-23

申请人： Roche Diabetes Care, Inc.

发明人： Otto Fuerst ,  Herbert Harttig ,  Bernd Hiller

IPC分类号： C12N11/10 ,  C12N9/04 ,  C12Q1/00 ,  C12Q1/54

CPC分类号： C12N11/10 ,  A61K9/5036 ,  A61K9/5089 ,  B05B7/1686 ,  C12N9/0006 ,  C12N11/04 ,  C12Q1/006 ,  C12Q1/54 ,  C12Y101/01047 ,  C12Y101/03004 ,  G01N33/66

摘要： The invention concerns a method and an apparatus for generation of micropartides containing an immobilized functional component, where the following measures are proposed: —spraying a liquid (32) containing a soluble alginate and a functional component consisting of molecules or nanoparticles to generate a stream (60) of droplets, —directing the stream (60) of droplets onto a precipitation bath (16) and capturing the droplets therein by application of high voltage (14), —precipitating the droplets in the precipitation bath (16) by means of a precipitation liquid (18) containing an alginate complexing agent, such that the droplets are solidified to form micropartides (10) containing the functional component and —extracting the micropartides (10) from the precipitation bath (16).

公开(公告)号：US09238697B2

公开(公告)日：2016-01-19

申请号：US11817051

申请日：2006-02-24

申请人： Zhibin Guan

发明人： Zhibin Guan

IPC分类号： A61K38/00 ,  C07K7/04 ,  C08B37/00 ,  C12N11/10

CPC分类号： C08B37/006 ,  C12N11/10

摘要： Chimeric polymer compositions and methods are provided in which a plurality of carbohydrate moieties and amino acids form the backbone of a polymer. Most preferably, the polymer includes alternating saccharide and peptide portions to form the chimeric polymer.

摘要翻译： 提供嵌合聚合物组合物和方法，其中多个碳水化合物部分和氨基酸形成聚合物的主链。 最优选地，聚合物包括交替的糖和肽部分以形成嵌合聚合物。

公开(公告)号：US20150275324A1

公开(公告)日：2015-10-01

申请号：US14433323

申请日：2013-10-09

申请人： BIOSIGMA S.A.

发明人： Patricio Ernesto Martinez Bellange ,  Pilar Angelica Parada Valdecantos

IPC分类号： C21B15/00 ,  C12N11/10

CPC分类号： C21B15/00 ,  C12N1/20 ,  C12N11/04 ,  C12N11/10 ,  C12P3/00 ,  C12P39/00 ,  C22B3/18 ,  Y02P10/234

摘要： The invention refers to viable biomining microorganisms encapsulated in alginate capsules, called BioSigma Bioleaching Seeds or BBS, wherein the alginate capsules have iron (II) and/or iron (III) ions as the cross-linking cations, and the usage of these capsules in the inoculation of these microorganisms in bioleaching processes

摘要翻译： 本发明涉及包封在藻酸盐胶囊中的生物生物微生物，称为BioSigma Bioleaching Seeds或BBS，其中藻酸盐胶囊具有作为交联阳离子的铁（II）和/或铁（III）离子，以及这些胶囊在 这些微生物在生物浸出过程中的接种

公开(公告)号：US08911980B2

公开(公告)日：2014-12-16

申请号：US13260142

申请日：2010-03-26

申请人： Junko Suzuki ,  Yoshie Yamauchi ,  Yuko Toyama ,  Satoshi Negishi

发明人： Junko Suzuki ,  Yoshie Yamauchi ,  Yuko Toyama ,  Satoshi Negishi

IPC分类号： C12N11/12 ,  C12N9/98 ,  C12N11/02 ,  C12N11/10 ,  C12N11/14 ,  C12N9/20

CPC分类号： C12N9/98 ,  C12N9/20 ,  C12N11/02 ,  C12N11/10 ,  C12N11/12 ,  C12N11/14 ,  C12Y301/01003

摘要： The present invention provides a method for producing a ground product of a lipase powder composition comprising an immobilized lipase in which a lipase derived from Thermomyces sp. is immobilized to a silica carrier and a hydrophilic powder other than a silica carrier, the method comprising the steps of wetting the hydrophilic powder with oil; separating the hydrophilic powder wetted with oil from the oil to obtain an oil-containing hydrophilic powder; mixing the oil-containing hydrophilic powder and the immobilized lipase at a ratio of 0.45:1 to 0.85:1 based on mass of the hydrophilic powder and the immobilized lipase before oil wetting; and grinding the obtained mixture, the steps being conducted in the above order.

摘要翻译： 本发明提供一种生产包含固定化脂肪酶的脂肪酶粉末组合物的研磨产物的方法，其中来自Thermomyces sp。 固定在二氧化硅载体和除二氧化硅载体以外的亲水性粉末，该方法包括用油润湿亲水性粉末的步骤; 分离从油中润湿的亲水性粉末，得到含油亲水性粉末; 以油润湿前的亲水性粉末和固定化脂肪酶的质量，以0.45:1〜0.85:1的比例混合含油亲水性粉末和固定化脂肪酶; 并研磨所得混合物，所述步骤按照上述顺序进行。

公开(公告)号：US20140322342A1

公开(公告)日：2014-10-30

申请号：US14237214

申请日：2012-08-09

申请人： Emmanuel C. Opara ,  Benjamin S. Harrison

发明人： Emmanuel C. Opara ,  Benjamin S. Harrison

IPC分类号： A61K35/39 ,  A61K31/555 ,  A61K38/44 ,  A61K9/50 ,  A61K33/40

CPC分类号： A61K35/39 ,  A61K9/0024 ,  A61K9/501 ,  A61K9/5015 ,  A61K9/5036 ,  A61K9/5073 ,  A61K31/555 ,  A61K33/40 ,  A61K38/1866 ,  A61K38/44 ,  A61K45/06 ,  A61K47/02 ,  A61K47/22 ,  A61K47/42 ,  C12N1/04 ,  C12N5/0676 ,  C12N11/04 ,  C12N11/10

摘要： Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described.

摘要翻译： 描述了包含（a）液体水性或水凝胶核心的微胶囊; （b）围绕所述芯的半透膜; （c）核心中的活的动物细胞（例如胰细胞）; 和（d）所述核心中的产氧颗粒，所述微胶囊中包含的产生氧的颗粒的量足以延长所述微胶囊中所述动物细胞存活的持续时间。 还描述了包含这种微胶囊的组合物及其用途，例如治疗糖尿病。

公开(公告)号：US20140127776A1

公开(公告)日：2014-05-08

申请号：US14125889

申请日：2012-06-13

申请人： Gaston Picard

发明人： Gaston Picard

IPC分类号： C12N11/10 ,  C12R1/89

CPC分类号： C12N11/10 ,  A01G33/00 ,  C12M21/02 ,  C12M23/48 ,  C12M25/02 ,  C12M33/12 ,  C12M33/18 ,  C12M33/20 ,  C12M41/08 ,  C12N1/12 ,  C12N11/08 ,  C12R1/89 ,  Y02A40/88 ,  Y02E50/13

摘要： Compositions, articles, apparatus, methods and systems are provided for the growth of algae immobilized on a support in a gaseous environment supplying access to sources of carbon dioxide and light, and for subsequent harvesting and biomass processing.

摘要翻译： 提供组合物，制品，仪器，方法和系统，用于在气体环境中固定在载体上的藻类的生长，供应二氧化碳和光源的进入，以及随后的收获和生物质处理。

公开(公告)号：US20130309746A1

公开(公告)日：2013-11-21

申请号：US13675659

申请日：2012-11-13

申请人： Augustine A. DiNovo ,  Dominic P. DiNovo ,  David A. Schofield ,  Matthew F. Smiechowski ,  Francis H. Verhoff

发明人： Augustine A. DiNovo ,  Dominic P. DiNovo ,  David A. Schofield ,  Matthew F. Smiechowski ,  Francis H. Verhoff

IPC分类号： C12N11/10

CPC分类号： C12N11/10 ,  C12N11/02 ,  C12N11/06 ,  C12N11/12

摘要： The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked enzyme having a support material which includes a biomass material different than the biomass used to initially derive the enzyme. Optionally, the immobilized enzyme further includes a polymeric material and/or the biomass which was used to initially derive the enzyme. The resulting immobilized enzyme materials may be biodegradable. The present application also discloses methods of making and using the disclosed immobilized enzyme materials.

摘要翻译： 本申请公开了包含具有支持材料的交联酶的固定化酶和固定化酶材料，所述载体材料包括与用于最初衍生酶的生物质不同的生物质材料。 任选地，固定化酶还包括用于最初衍生酶的聚合物材料和/或生物质。 得到的固定化酶材料可以是可生物降解的。 本申请还公开了制备和使用所公开的固定化酶材料的方法。