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公开(公告)号：US08216560B2
公开(公告)日：2012-07-10
申请号：US12055726
申请日：2008-03-26
申请人： Dominique Charmot , Han Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
发明人： Dominique Charmot , Han Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
IPC分类号： A61K31/74
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高钾血症的药物。
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公开(公告)号：US20080241092A1
公开(公告)日：2008-10-02
申请号：US12055726
申请日：2008-03-26
申请人： Dominique Charmot , Han-Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
发明人： Dominique Charmot , Han-Ting Chang , John Fordtran , Gerrit Klaerner , Jerry M. Buysse , Robert Alpern , Mingjun Liu
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
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公开(公告)号：US07854924B2
公开(公告)日：2010-12-21
申请号：US10814527
申请日：2004-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
CPC分类号： A61K31/74
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：US07776319B2
公开(公告)日：2010-08-17
申请号：US11095760
申请日：2005-03-30
申请人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
发明人： Robert Alpern , Jerry Buysse , Han Ting Chang , Dominique Charmot , Michael James Cope , John Fordtran , Gerrit Klaerner , Eric Connor , Mingjun Liu , Futian Liu , Jun Shao
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K9/14 , A61P3/12 , A61P9/12 , A61P13/12
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钠结合聚合物及其药物组合物的组合物。 本文公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 这些方法的实例包括治疗高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US07718746B2
公开(公告)日：2010-05-18
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08F26/06 , C07C211/11
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不能用于高于聚合物的目标离子的一定百分比MW的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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公开(公告)号：US20100029897A1
公开(公告)日：2010-02-04
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08G73/00
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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7.发明授权Pharmaceutical compositions comprising cross-linked small molecule amine polymers 失效包含交联的小分子胺聚合物的药物组合物公开(公告)号：US07608674B2
公开(公告)日：2009-10-27
申请号：US10980991
申请日：2004-11-03
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译： 描述了阴离子结合聚合物。 阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。 在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不可用于高于聚合物的靶离子MW的一定百分比的非相互作用溶质。 在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。 还描述了药物组合物，使用方法和试剂盒。
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公开(公告)号：US07429394B2
公开(公告)日：2008-09-30
申请号：US11095918
申请日：2005-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K45/06
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐失衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过量。
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公开(公告)号：US08192758B2
公开(公告)日：2012-06-05
申请号：US10814749
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
IPC分类号： A61K9/14
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了核 - 壳组合物及其药物组合物。 本文公开了用于治疗和/或预防益处的核 - 壳组合物的使用方法。 这些方法的实例包括治疗磷酸盐不平衡障碍，高血压，慢性心力衰竭，终末期肾病，肝硬化，慢性肾功能不全，流体过载或钠过载。
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公开(公告)号：US08282960B2
公开(公告)日：2012-10-09
申请号：US10813872
申请日：2004-03-30
申请人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
发明人： Dominique Charmot , John Fordtran , Han Ting Chang , Eric Connor , Mingjun Liu , Gerrit Klaerner
CPC分类号： A61K9/5031 , A61K9/5026 , A61K9/5047
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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