公开(公告)号：US08771344B2

公开(公告)日：2014-07-08

申请号：US13967894

申请日：2013-08-15

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonel Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonel Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20140005769A1

公开(公告)日：2014-01-02

申请号：US13967894

申请日：2013-08-15

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US08512400B2

公开(公告)日：2013-08-20

申请号：US12757111

申请日：2010-04-09

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20110251680A1

公开(公告)日：2011-10-13

申请号：US12757111

申请日：2010-04-09

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US08876892B2

公开(公告)日：2014-11-04

申请号：US13091949

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418

摘要： A device for percutaneously deploying a stented prosthetic heart valve includes a distal portion, a spacing collar, and an outer collar. The distal portion provides a coupling structure configured to selectively engage the stented prosthetic heart valve. The spacing collar is located proximal to the distal portion. The spacing collar is transitionable from a loaded state to an activated state. The spacing collar in the loaded state has a radial dimension less than the spacing collar in the activated state. The outer collar is configured to be movable relative to the distal portion and the spacing collar. The outer collar is slidably disposed over the spacing collar to provide the loaded state and is slidably retracted from the spacing collar when in the activated state.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的装置包括远侧部分，间隔环和外部套环。 远端部分提供构造成选择性地接合支架置入的假体心脏瓣膜的联接结构。 间隔环位于远端部分附近。 间隔环可以从负载状态转换到激活状态。 处于加载状态的间隔环具有小于处于活化状态的间隔环的径向尺寸。 外套环构造成相对于远侧部分和间隔环可移动。 外套环可滑动地设置在间隔环上方以提供加载状态，并且当处于激活状态时可从间隔套环可滑动地缩回。

公开(公告)号：US20110264200A1

公开(公告)日：2011-10-27

申请号：US13091949

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418

摘要： A device for percutaneously deploying a stented prosthetic heart valve includes a distal portion, a spacing collar, and an outer collar. The distal portion provides a coupling structure configured to selectively engage the stented prosthetic heart valve. The spacing collar is located proximal to the distal portion. The spacing collar is transitionable from a loaded state to an activated state. The spacing collar in the loaded state has a radial dimension less than the spacing collar in the activated state. The outer collar is configured to be movable relative to the distal portion and the spacing collar. The outer collar is slidably disposed over the spacing collar to provide the loaded state and is slidably retracted from the spacing collar when in the activated state.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的装置包括远侧部分，间隔环和外部套环。 远端部分提供构造成选择性地接合支架置入的假体心脏瓣膜的联接结构。 间隔环位于远端部分附近。 间隔环可以从负载状态转换到激活状态。 处于加载状态的间隔环具有小于处于活化状态的间隔环的径向尺寸。 外套环构造成相对于远侧部分和间隔环可移动。 外套环可滑动地设置在间隔环上方以提供加载状态，并且当处于激活状态时可从间隔套环可滑动地缩回。

公开(公告)号：US08740976B2

公开(公告)日：2014-06-03

申请号：US13091938

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer

发明人： Don Tran ,  Nathan Wiemeyer

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A delivery system for use with a prosthetic heart valve having a stent frame to which a valve structure is attached includes a shaft assembly including a distal portion and an intermediate portion, and an inner lumen extending through the shaft assembly. The delivery system includes a sheath assembly defining an outer lumen sized to slidably receive the shaft assembly. At least one flush port is formed in the intermediate portion. The at least one flush port is in fluid communication with the inner lumen and the outer lumen. The delivery system is configured to transition from a loaded state in which the sheath assembly encompasses the prosthetic heart valve to a deployed state in which the sheath assembly is withdrawn from the prosthetic heart valve.

摘要翻译： 用于具有附接有阀结构的支架框架的假体心脏瓣膜的输送系统包括：轴组件，其包括远端部分和中间部分;以及内腔，其延伸穿过所述轴组件。 输送系统包括护套组件，其限定尺寸适于可滑动地容纳轴组件的外腔。 在中间部分形成至少一个冲洗口。 至少一个冲洗口与内腔和外腔流体连通。 输送系统被配置成从其中护套组件包围假体心脏瓣膜的负载状态转变到其中护套组件从假体心脏瓣膜抽出的展开状态。

公开(公告)号：US20110264199A1

公开(公告)日：2011-10-27

申请号：US13091938

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer

发明人： Don Tran ,  Nathan Wiemeyer

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A delivery system for use with a prosthetic heart valve having a stent frame to which a valve structure is attached includes a shaft assembly including a distal portion and an intermediate portion, and an inner lumen extending through the shaft assembly. The delivery system includes a sheath assembly defining an outer lumen sized to slidably receive the shaft assembly. At least one flush port is formed in the intermediate portion. The at least one flush port is in fluid communication with the inner lumen and the outer lumen. The delivery system is configured to transition from a loaded state in which the sheath assembly encompasses the prosthetic heart valve to a deployed state in which the sheath assembly is withdrawn from the prosthetic heart valve.

摘要翻译： 用于具有附接有阀结构的支架框架的假体心脏瓣膜的输送系统包括：轴组件，其包括远端部分和中间部分;以及内腔，其延伸穿过所述轴组件。 输送系统包括护套组件，其限定尺寸适于可滑动地容纳轴组件的外腔。 在中间部分形成至少一个冲洗口。 至少一个冲洗口与内腔和外腔流体连通。 输送系统被配置成从其中护套组件包围假体心脏瓣膜的负载状态转变到其中护套组件从假体心脏瓣膜抽出的展开状态。

公开(公告)号：US08727996B2

公开(公告)日：2014-05-20

申请号：US13090834

申请日：2011-04-20

申请人： James Calvin Allan ,  Don Tran ,  Erik Griswold ,  Rudy Beasley ,  Arvind Srinivas

发明人： James Calvin Allan ,  Don Tran ,  Erik Griswold ,  Rudy Beasley ,  Arvind Srinivas

IPC分类号： A61B5/02 ,  A61B18/18 ,  A61M29/00 ,  A61F2/06 ,  A61N1/00

CPC分类号： A61B5/0215 ,  A61B5/6839 ,  A61B5/686

摘要： A delivery device for implanting a medical device that includes an expandable fixation member adapted to fix the position of the medical device within a lumen of a human body. The delivery device has an inner shaft rotatably disposed in a tubular outer shaft. A retention member is secured to and rotatable with the inner shaft and has a free end and a retainer portion adapted to protrude outwardly through an exit aperture in the outer shaft to extend circumferentially about the exterior of the outer shaft. The fixation member of the medical device may be retained on the tubular shaft in a low profile configuration by the outwardly protruding retainer portion and may be released to expand upon retraction of the retainer portion in response to rotation of the inner shaft.

摘要翻译： 一种用于植入医疗装置的输送装置，其包括适于将医疗装置的位置固定在人体内腔内的可扩张固定构件。 输送装置具有可旋转地设置在管状外轴中的内轴。 保持构件固定到内轴上并与内轴可旋转，并且具有自由端和适于从外轴的出口孔向外突出的保持器部分，以围绕外轴的外部周向延伸。 医疗装置的固定构件可以通过向外突出的保持器部分以低轮廓构造保持在管状轴上，并且可以在响应于内轴的旋转而缩回保持器部分时释放膨胀。

公开(公告)号：US08478431B2

公开(公告)日：2013-07-02

申请号：US13047456

申请日：2011-03-14

申请人： Erik Griswold ,  James Calvin Allan ,  Don Tran

发明人： Erik Griswold ,  James Calvin Allan ,  Don Tran

IPC分类号： A61N1/00

CPC分类号： A61N1/37205 ,  A61B17/3468 ,  A61N1/0573 ,  A61N1/362 ,  A61N1/3756 ,  A61N2001/083

摘要： A fixation device for retaining a leadless medical implant to tissue includes an array of elongate tines having self-expanding distal portions. The fixation tines may be advanced between an implant body and an outer jacket to deploy the tines from a delivery configuration in which the tines are constrained by the outer jacket to an expanded configuration in which the distal end portions of the tines are released from the outer jacket. The implant and fixation device are contained within a sheath for delivery to the treatment site and a pusher within the sheath advances the fixation device relative to the implant body and deploys the tines. A distal end of the implant having an electrode may form a distal tip of the delivery system, and a potential implantation site may be tested prior to deployment of the fixation device to allow for easy repositioning of the implant.

摘要翻译： 用于将无引线医用植入物保持在组织上的固定装置包括具有自扩张远侧部分的细长尖齿阵列。 固定齿可以在植入物主体和外护套之间前进，以将齿从其中齿由外护套约束的输送构型展开到扩张构型，其中尖齿的远端部分从外部释放 夹克。 植入物和固定装置包含在护套内用于输送到治疗部位，并且护套内的推动器相对于植入体前进固定装置并且展开齿。 具有电极的植入物的远端可以形成递送系统的远侧末端，并且可以在展开固定装置之前测试潜在的植入部位，以便容易地重新定位植入物。