公开(公告)号：US08876892B2

公开(公告)日：2014-11-04

申请号：US13091949

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418

摘要： A device for percutaneously deploying a stented prosthetic heart valve includes a distal portion, a spacing collar, and an outer collar. The distal portion provides a coupling structure configured to selectively engage the stented prosthetic heart valve. The spacing collar is located proximal to the distal portion. The spacing collar is transitionable from a loaded state to an activated state. The spacing collar in the loaded state has a radial dimension less than the spacing collar in the activated state. The outer collar is configured to be movable relative to the distal portion and the spacing collar. The outer collar is slidably disposed over the spacing collar to provide the loaded state and is slidably retracted from the spacing collar when in the activated state.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的装置包括远侧部分，间隔环和外部套环。 远端部分提供构造成选择性地接合支架置入的假体心脏瓣膜的联接结构。 间隔环位于远端部分附近。 间隔环可以从负载状态转换到激活状态。 处于加载状态的间隔环具有小于处于活化状态的间隔环的径向尺寸。 外套环构造成相对于远侧部分和间隔环可移动。 外套环可滑动地设置在间隔环上方以提供加载状态，并且当处于激活状态时可从间隔套环可滑动地缩回。

公开(公告)号：US20110264200A1

公开(公告)日：2011-10-27

申请号：US13091949

申请日：2011-04-21

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418

摘要： A device for percutaneously deploying a stented prosthetic heart valve includes a distal portion, a spacing collar, and an outer collar. The distal portion provides a coupling structure configured to selectively engage the stented prosthetic heart valve. The spacing collar is located proximal to the distal portion. The spacing collar is transitionable from a loaded state to an activated state. The spacing collar in the loaded state has a radial dimension less than the spacing collar in the activated state. The outer collar is configured to be movable relative to the distal portion and the spacing collar. The outer collar is slidably disposed over the spacing collar to provide the loaded state and is slidably retracted from the spacing collar when in the activated state.

摘要翻译： 用于经皮部署支架假体心脏瓣膜的装置包括远侧部分，间隔环和外部套环。 远端部分提供构造成选择性地接合支架置入的假体心脏瓣膜的联接结构。 间隔环位于远端部分附近。 间隔环可以从负载状态转换到激活状态。 处于加载状态的间隔环具有小于处于活化状态的间隔环的径向尺寸。 外套环构造成相对于远侧部分和间隔环可移动。 外套环可滑动地设置在间隔环上方以提供加载状态，并且当处于激活状态时可从间隔套环可滑动地缩回。

公开(公告)号：US08771344B2

公开(公告)日：2014-07-08

申请号：US13967894

申请日：2013-08-15

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonel Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonel Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20140005769A1

公开(公告)日：2014-01-02

申请号：US13967894

申请日：2013-08-15

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US08512400B2

公开(公告)日：2013-08-20

申请号：US12757111

申请日：2010-04-09

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20110251680A1

公开(公告)日：2011-10-13

申请号：US12757111

申请日：2010-04-09

申请人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

发明人： Don Tran ,  Nathan Wiemeyer ,  Susheel Deshmukh ,  Leonal Mendoza ,  Matthew Rust

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2418 ,  A61F2250/0018 ,  A61F2250/0039

摘要： A device for percutaneously repairing a heart valve of a patient including a self-expanding, stented prosthetic heart valve and a delivery system. The delivery system includes delivery sheath slidably receiving an inner shaft forming a coupling structure. A capsule of the delivery sheath includes a distal segment and a proximal segment. An outer diameter of the distal segment is greater than that of the proximal segment. An area moment of inertia of the distal segment can be greater than an area moment of inertia of the proximal segment. Regardless, an axial length of the distal segment is less than the axial length of the prosthesis. In a loaded state, the prosthesis engages the coupling structure and is compressively retained within the capsule. The capsule is unlikely to kink when traversing the patient's vasculature, such as when tracking around the aortic arch, promoting recapturing of the prosthesis.

摘要翻译： 一种用于经皮修复患者的心脏瓣膜的装置，包括自膨胀，支架假体心脏瓣膜和输送系统。 输送系统包括可滑动地接收形成联接结构的内轴的输送护套。 输送鞘的囊包括远端段和近端段。 远侧段的外径大于近端段的外径。 远侧段的面积惯性矩可以大于近端段的面积惯性矩。 无论如何，远端段的轴向长度小于假体的轴向长度。 在装载状态下，假体接合联接结构并被压缩地保持在胶囊内。 当穿过患者的脉管系统时，例如当跟踪主动脉弓周围时，胶囊不可能扭结，促进假体的重新捕获。

公开(公告)号：US20110251679A1

公开(公告)日：2011-10-13

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US08491650B2

公开(公告)日：2013-07-23

申请号：US12756843

申请日：2010-04-08

申请人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

发明人： Nathan Wiemeyer ,  Robert Murray, III ,  Siyan Som ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2436

摘要： A device for percutaneously delivering a stented prosthetic heart valve. The device includes an inner shaft, a delivery sheath, stability tube, and a handle. The delivery sheath is slidably disposed over the inner shaft, and includes a capsule compressively containing the prosthesis over the inner shaft. The stability tube is coaxially received over the delivery sheath, and includes a distal region. A circumferential rigidity of the capsule is greater than a circumferential rigidity of the distal region. In transitioning from a delivery state to a deployed state, the capsule is withdrawn from the prosthetic heart valve and at least partially into the distal region to permit the prosthesis to self-deploy. The capsule forces the distal region to stretch and expand in diameter.

摘要翻译： 用于经皮递送支架假体心脏瓣膜的装置。 该装置包括内轴，输送护套，稳定管和手柄。 输送护套可滑动地设置在内轴上方，并且包括在内轴上压缩地容纳假体的胶囊。 稳定管同轴地容纳在输送护套上，并且包括远端区域。 胶囊的圆周刚度大于远侧区域的圆周刚度。 在从输送状态转换到展开状态时，将胶囊从假体心脏瓣膜中抽出并且至少部分地进入远端区域以允许假体自我展开。 胶囊迫使远端区域直径伸展和扩张。

公开(公告)号：US20110264201A1

公开(公告)日：2011-10-27

申请号：US13094455

申请日：2011-04-26

申请人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

发明人： Hubert Yeung ,  Mike Krivoruchko ,  Susheel Deshmukh

IPC分类号： A61F2/24

CPC分类号： A61F2/2433 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/95 ,  A61F2002/9534 ,  A61F2230/0054 ,  A61F2230/008 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61M25/1002 ,  A61M25/104 ,  A61M2025/1059

摘要： A system and method for restoring (e.g., replacing) a defective heart valve of a patient. A delivery system is manipulated to percutaneously deliver and implant a stented prosthetic heart valve to a native heart valve. A post-dilatation balloon is percutaneously delivered to the implantation site, and a compliant segment thereof is arranged within a region of the implanted prosthesis. The balloon is inflated such that the compliant segment expands and contacts the prosthesis, expanding a remodeling region of the prosthesis to a remodeled state. With these and related techniques, remodeling of an implanted, stented prosthetic heart valve to better match the native valve shape is possible, providing many benefits such as reducing the risk of paravalvular leaks.

摘要翻译： 用于恢复（例如，更换）患者的有缺陷的心脏瓣膜的系统和方法。 操纵输送系统以经皮递送和植入支架假体心脏瓣膜至天然心脏瓣膜。 经扩张后的球囊经皮递送至植入部位，并且其顺从段布置在植入假体的区域内。 气囊膨胀使得顺应部分膨胀并接触假体，将假体的重建区域扩展至改造状态。 利用这些和相关技术，植入式支架假体心脏瓣膜的重塑是可能的，以提供许多益处，例如减少瓣膜泄漏的风险。

公开(公告)号：US20110098804A1

公开(公告)日：2011-04-28

申请号：US12886975

申请日：2010-09-21

申请人： Hubert Yeung ,  John Shanahan ,  Joshua Dwork ,  Adam Shipley ,  Jeffrey Allen ,  Susheel Deshmukh ,  Kishore Udipi ,  Ya Guo

发明人： Hubert Yeung ,  John Shanahan ,  Joshua Dwork ,  Adam Shipley ,  Jeffrey Allen ,  Susheel Deshmukh ,  Kishore Udipi ,  Ya Guo

IPC分类号： A61F2/24

CPC分类号： A61F2/2436 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/966 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008

摘要： A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

摘要翻译： 一种经皮支架置入的瓣膜输送装置，包括内轴，护套和输送胶囊。 护套可滑动地容纳内轴。 胶囊近端区域附接到护套。 胶囊远端区域被配置为在正常和扩张状态之间转变。 远端区域的直径在扩张状态下较大，并且胶囊包括自然地呈现正常状态的形状记忆组件。 该装置可操作以执行可逆部分展开过程，其中假体的一部分暴露在胶囊的远端并允许径向扩张。 随后，随着胶囊的远端前进，远侧区域转变到扩张状态并且将塌陷力施加到假体上，导致假体径向折叠并在输送胶囊内重新捕获。 胶囊可以包括由聚合物包封的激光切割管。