-
1.发明申请公开(公告)号：US20080176846A1
公开(公告)日：2008-07-24
申请号：US11873196
申请日：2007-10-16
申请人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
发明人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/5377 , A61P35/00 , A61P37/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61K31/496 , A61K31/506
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit，PDGFRα，PDGFRβ，CSF1R，Abl，BCR-Abl，CSK，JNK1，JNK2，p38等的异常活化的疾病或病症的方法。 p70S6K，TGFbeta，SRC，EGFR，trkB，FGFR3，FLT3，Fes，Lck，Syk，RAF，MKK4，MKK6，SAPK2beta，BRK，KDR，c-raf或b-raf激酶或其突变形式。
-
2.发明申请公开(公告)号：US20100081656A1
公开(公告)日：2010-04-01
申请号：US12629665
申请日：2009-12-02
申请人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
发明人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
IPC分类号： A61K31/5377 , A61K31/496 , C07D413/14 , C07D401/14 , C07D471/04 , A61P25/22 , A61K31/4375 , A61P25/28 , A61P25/16 , A61P3/10 , A61P3/04
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit，PDGFRα，PDGFR和bgr，CSF1R，Abl，BCR-Abl，CSK，JNK1，JNK2，p38异常活化的疾病或病症的方法 ，p70S6K，TGF-bgr，SRC，EGFR，trkB，FGFR3，FLT3，Fes，Lck，Syk，RAF，MKK4，MKK6，SAPK2＆bgr，BRK，KDR，c-raf或b-raf激酶或其突变形式。
-
3.发明授权公开(公告)号：US07678792B2
公开(公告)日：2010-03-16
申请号：US11873196
申请日：2007-10-16
申请人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
发明人： Donatella Chianelli , Christopher Cow , Yun He , Songchun Jiang , Xiaolin Li , Xiaodong Liu , Zuosheng Liu , Jon Loren , Valentina Molteni , Juliet Nabakka , Pingda Ren , Taebo Sim , Xiaodong Wang , Shuli You
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/497 , A61K31/501 , A61K31/5355 , A61K31/506 , C07D413/14 , C07D213/69 , C07D213/61 , C07D213/74 , C07D213/80 , C07C205/06 , C07C301/00 , C07C255/07 , C07C69/73 , A61P17/10 , A61P29/00 , A61P3/10 , A61P31/00 , A61P27/14
CPC分类号： C07D471/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
摘要翻译： 本发明提供了可用作蛋白激酶抑制剂的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调激酶活性相关的病症的方法。 在一些实施方案中，本发明提供了使用这些化合物治疗，改善或预防涉及c-kit，PDGFRα，PDGFR和bgr，CSF1R，Abl，BCR-Abl，CSK，JNK1，JNK2，p38异常活化的疾病或病症的方法 ，p70S6K，TGF-bgr，SRC，EGFR，trkB，FGFR3，FLT3，Fes，Lck，Syk，RAF，MKK4，MKK6，SAPK2＆bgr，BRK，KDR，c-raf或b-raf激酶或其突变形式。
-
公开(公告)号：US20090137610A1
公开(公告)日：2009-05-28
申请号：US12160302
申请日：2007-01-25
申请人： Robert Epple , Ross Russo , Mihai Azimioara , Christopher Cow , Valentina Molteni , Xiaolin Li , Donatella Chianelli
发明人： Robert Epple , Ross Russo , Mihai Azimioara , Christopher Cow , Valentina Molteni , Xiaolin Li , Donatella Chianelli
IPC分类号： A61K31/438 , C07D471/10 , A61K31/506
CPC分类号： C07D471/10
摘要： The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
摘要翻译： 本发明提供化合物（Ia），（Ib）和（Ic），包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体（PPAR）家族的活性相关的疾病或病症的方法。
-
公开(公告)号：US08153635B2
公开(公告)日：2012-04-10
申请号：US12204600
申请日：2008-09-04
申请人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin
发明人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin
IPC分类号： A61K31/496
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
摘要： The invention provides compounds of Formula I: wherein A, L, m, q, Q, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention. The invention further provides for pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译： 本发明提供了式I的化合物：其中A，L，m，q，Q，R 1，R 2，R 3，R 4和R 5在发明概述中定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
-
公开(公告)号：US20100022515A1
公开(公告)日：2010-01-28
申请号：US12525289
申请日：2008-01-22
申请人： Phillip B. Alper , Mihai D. Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Truc Ngoc Nguyen , Lucas Westcott-Baker , Baogen Wu
发明人： Phillip B. Alper , Mihai D. Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Truc Ngoc Nguyen , Lucas Westcott-Baker , Baogen Wu
IPC分类号： A61K31/55 , C07D401/14 , A61K31/4709 , A61K31/5377 , A61K31/497 , C07D413/14 , C07D401/12
CPC分类号： C07D401/12 , C07D217/08 , C07D401/06 , C07D401/10 , C07D401/14 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D487/04 , C07D495/04
摘要： The invention provides compounds, pharmaceutical compositions comprising compound of following formula (I), and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119 (G protein-coupled receptor 119) such as obesity, diabetes and hyperlipidemia.
摘要翻译： 本发明提供化合物，包含下式（I）化合物的药物组合物和使用这些化合物治疗或预防与GPR119（G蛋白偶联受体119）的活性相关的疾病或病症的方法，例如肥胖症，糖尿病和高脂血症 。
-
公开(公告)号：US20120196844A1
公开(公告)日：2012-08-02
申请号：US13423041
申请日：2012-03-16
申请人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
发明人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC分类号： A61K31/496 , C07D401/14 , A61K31/497 , A61K31/501 , A61K31/551 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/00 , A61P9/10 , A61P3/08 , A61P3/00 , A61P19/02 , A61P19/10 , A61P9/12 , A61P9/04 , A61P27/02 , A61P27/12 , A61P13/12 , A61P7/02 , A61P7/00 , A61P15/10 , A61P17/00 , A61P19/04 , A61P1/04 , C12N5/02 , C07D401/12
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
-
公开(公告)号：US20110224185A1
公开(公告)日：2011-09-15
申请号：US13113988
申请日：2011-05-23
申请人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
发明人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC分类号： A61K31/397 , C07D405/14 , A61K31/506 , C07D401/14 , C07D401/12 , A61K31/4545 , A61K31/497 , A61K31/496 , A61K31/551 , C07D487/04 , A61K31/4985 , A61K31/501 , C07D413/14 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P19/00 , A61P13/12 , A61P3/06 , A61P17/00 , C12N5/02
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
-
公开(公告)号：US20110190263A1
公开(公告)日：2011-08-04
申请号：US12918803
申请日：2009-02-20
申请人： Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Baogen Wu , Daniel Mutnick
发明人： Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Baogen Wu , Daniel Mutnick
IPC分类号： A61K31/519 , C12N5/02 , C07D471/04 , A61K31/506 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/00 , A61P19/02 , A61P19/10 , A61P9/02 , A61P13/12 , A61P17/00 , A61P1/00
CPC分类号： C07D471/04
摘要： The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译： 本发明提供式（I）化合物：包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
-
公开(公告)号：US20090270409A1
公开(公告)日：2009-10-29
申请号：US12204600
申请日：2008-09-04
申请人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
发明人： Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC分类号： A61K31/497 , C07D401/02 , C07D409/14 , C07D241/04
CPC分类号： C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.058 秒)
