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公开(公告)号:US07820705B2
公开(公告)日:2010-10-26
申请号:US11596596
申请日:2005-05-12
申请人: Robert Epple , Ross Russo , Mihai Azimioara , Yongping Xie
发明人: Robert Epple , Ross Russo , Mihai Azimioara , Yongping Xie
IPC分类号: C07D413/04 , C07D261/18 , A61K31/4439 , A61K31/422 , A61K31/42
CPC分类号: C07D261/08 , C07D261/18 , C07D413/04
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体(PPAR)家族的活性相关的疾病或病症的方法,特别是PPAR的活性。
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公开(公告)号:US07745445B2
公开(公告)日:2010-06-29
申请号:US11596598
申请日:2005-05-13
申请人: Robert Epple , Mihai Azimioara
发明人: Robert Epple , Mihai Azimioara
IPC分类号: A61K31/47 , C07D215/00
CPC分类号: C07D215/14 , A61K31/19 , A61K31/215 , A61K31/47 , A61K45/06 , C07C59/68 , C07C59/70 , C07C217/76 , C07C255/54 , C07C317/22 , C07C323/19 , C07C323/20 , C07C323/62 , C07D213/28 , C07D213/61 , C07D215/12 , C07D239/26 , C07D307/40 , C07D307/80 , A61K2300/00
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARδ.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体(PPAR)家族的活性相关的疾病或病症的方法,特别是PPARδ的活性。
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公开(公告)号:US20070259890A1
公开(公告)日:2007-11-08
申请号:US11596598
申请日:2005-05-13
申请人: Robert Epple , Mihai Azimioara
发明人: Robert Epple , Mihai Azimioara
IPC分类号: A61K31/50 , A61K31/075 , A61P31/00 , C07C321/00 , C07D239/02 , C07C43/02 , A61P9/00 , A61K31/10
CPC分类号: C07D215/14 , A61K31/19 , A61K31/215 , A61K31/47 , A61K45/06 , C07C59/68 , C07C59/70 , C07C217/76 , C07C255/54 , C07C317/22 , C07C323/19 , C07C323/20 , C07C323/62 , C07D213/28 , C07D213/61 , C07D215/12 , C07D239/26 , C07D307/40 , C07D307/80 , A61K2300/00
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPARδ.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体(PPAR)家族的活性相关的疾病或病症的方法,特别是PPARδ的活性。
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公开(公告)号:US08575168B2
公开(公告)日:2013-11-05
申请号:US12896735
申请日:2010-10-01
申请人: Mihai Azimioara , Christopher Cow , Robert Epple , Gerald Lelais , John Mecom , Victor Nikulin
发明人: Mihai Azimioara , Christopher Cow , Robert Epple , Gerald Lelais , John Mecom , Victor Nikulin
IPC分类号: A61K31/497 , A61K31/445 , C07D239/42 , C07D239/00 , C07D241/00 , C07D401/00 , C07D405/00
CPC分类号: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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公开(公告)号:US20110224185A1
公开(公告)日:2011-09-15
申请号:US13113988
申请日:2011-05-23
申请人: Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
发明人: Phillip B. Alper , Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Pierre-Yves Michellys , Daniel Mutnick , Victor Nikulin , Lucas Westcott-Baker
IPC分类号: A61K31/397 , C07D405/14 , A61K31/506 , C07D401/14 , C07D401/12 , A61K31/4545 , A61K31/497 , A61K31/496 , A61K31/551 , C07D487/04 , A61K31/4985 , A61K31/501 , C07D413/14 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P19/00 , A61P13/12 , A61P3/06 , A61P17/00 , C12N5/02
CPC分类号: C07D401/10 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/048
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
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6.
公开(公告)号:US20110190263A1
公开(公告)日:2011-08-04
申请号:US12918803
申请日:2009-02-20
申请人: Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Baogen Wu , Daniel Mutnick
发明人: Mihai Azimioara , Christopher Cow , Robert Epple , Songchun Jiang , Gerald Lelais , Baogen Wu , Daniel Mutnick
IPC分类号: A61K31/519 , C12N5/02 , C07D471/04 , A61K31/506 , A61P3/04 , A61P3/10 , A61P3/06 , A61P9/00 , A61P19/02 , A61P19/10 , A61P9/02 , A61P13/12 , A61P17/00 , A61P1/00
CPC分类号: C07D471/04
摘要: The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
摘要翻译: 本发明提供式(I)化合物:包含这些化合物的药物组合物和使用这些化合物治疗或预防与GPR119活性相关的疾病或病症的方法。
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公开(公告)号:US07750032B2
公开(公告)日:2010-07-06
申请号:US11815096
申请日:2006-02-03
申请人: Christopher Cow , Robert Epple , Xing Wang , Yongping Xie , Hans Martin Seidel
发明人: Christopher Cow , Robert Epple , Xing Wang , Yongping Xie , Hans Martin Seidel
IPC分类号: C07D213/64 , C07D265/30 , C07D233/64 , C07D231/12 , C07D413/10 , C07D401/04 , A61K31/4155 , A61K31/4178 , A61K31/4164 , A61K31/4439 , A61K31/5377
CPC分类号: C07D249/08 , C07D401/04 , C07D403/04 , C07D405/04
摘要: The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the peroxisome proliferator-activated receptor (PPAR) families, particularly the activity of PPARδ.
摘要翻译: 本发明提供式I的三取代吡唑和咪唑:其中L2,q,R13,R14,R15,R16,Z1和Z2如发明概述所述; 以及使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体(PPAR)家族的活性相关的疾病或病症的方法,特别是PPARδ的活性。
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公开(公告)号:US20070244130A1
公开(公告)日:2007-10-18
申请号:US11597260
申请日:2005-05-24
申请人: Robert Epple , Yongping Xie , Xing Wang , Christopher Cow , Ross Russo
发明人: Robert Epple , Yongping Xie , Xing Wang , Christopher Cow , Ross Russo
IPC分类号: A01N43/54 , A61K31/42 , A61K31/435 , C07D263/30 , C07D401/00 , C07D411/00
CPC分类号: C07D413/04 , C07D263/32
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体(PPAR)家族的活性相关的疾病或病症的方法,特别是PPAR的活性。
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公开(公告)号:US20070203155A1
公开(公告)日:2007-08-30
申请号:US11597282
申请日:2005-05-24
申请人: Robert Epple , Christopher Cow , Yongping Xie , Xing Wang , Ross Russo , Mihai Azimioara , Enrique Saez
发明人: Robert Epple , Christopher Cow , Yongping Xie , Xing Wang , Ross Russo , Mihai Azimioara , Enrique Saez
IPC分类号: A61K31/506 , A61K31/4709 , A61K31/4439 , A61K31/426 , A61K31/427 , C07D417/02
CPC分类号: C07D277/24 , C07D277/16 , C07D277/36 , C07D417/04 , C07D417/14
摘要: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
摘要翻译: 本发明提供化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与过氧化物酶体增殖物激活受体(PPAR)家族的活性相关的疾病或病症的方法,特别是PPAR的活性。
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公开(公告)号:US20070123523A1
公开(公告)日:2007-05-31
申请号:US11620608
申请日:2007-01-05
申请人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人: Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号: A61K31/165 , A61K31/54 , A61K31/497 , A61K31/445
CPC分类号: C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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