公开(公告)号：US20130078253A1

公开(公告)日：2013-03-28

申请号：US13436411

申请日：2012-03-30

Applicant: Dong FANG ,  Paul MOORE ,  Steve RUBEN ,  Sudeepta AGGARWAL

Inventor： Dong FANG ,  Paul MOORE ,  Steve RUBEN ,  Sudeepta AGGARWAL

IPC: A61K39/395 ,  G01N33/574 ,  C07K16/18

CPC classification number: C07K16/249 ,  A61K39/39533 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/57 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/10

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供用于评估，治疗和预防使用癌症相关靶（CAT）的疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。