公开(公告)号：US20130078253A1

公开(公告)日：2013-03-28

申请号：US13436411

申请日：2012-03-30

Applicant: Dong FANG ,  Paul MOORE ,  Steve RUBEN ,  Sudeepta AGGARWAL

Inventor： Dong FANG ,  Paul MOORE ,  Steve RUBEN ,  Sudeepta AGGARWAL

IPC: A61K39/395 ,  G01N33/574 ,  C07K16/18

CPC classification number: C07K16/249 ,  A61K39/39533 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/57 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/57484 ,  G01N2500/10

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供用于评估，治疗和预防使用癌症相关靶（CAT）的疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US20120177659A1

公开(公告)日：2012-07-12

申请号：US13339833

申请日：2011-12-29

Applicant: Steve RUBEN ,  Karen VAN ORDEN ,  Candy N. LEE ,  Tao HE ,  Mehdi MESRI ,  Elizabeth G. JOSELOFF ,  Paul MOORE ,  Katherine MCKINNON ,  Bruno DOMON

Inventor： Steve RUBEN ,  Karen VAN ORDEN ,  Candy N. LEE ,  Tao HE ,  Mehdi MESRI ,  Elizabeth G. JOSELOFF ,  Paul MOORE ,  Katherine MCKINNON ,  Bruno DOMON

IPC: A61K39/395 ,  C07K14/47 ,  C12N9/10 ,  C12N9/12 ,  C12N9/48 ,  C12N9/14 ,  A61K38/02 ,  A61K38/17 ,  A61K38/45 ,  A61K38/48 ,  A61K38/46 ,  C07H21/04 ,  C07H21/02 ,  C07K16/18 ,  C07K16/28 ,  C07K16/40 ,  C07K16/42 ,  C12N5/16 ,  C12N5/071 ,  C12N5/09 ,  G01N33/566 ,  C12Q1/68 ,  A61P35/00 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C07K14/705

CPC classification number: G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.

Abstract translation: 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。

公开(公告)号：US20100061977A1

公开(公告)日：2010-03-11

申请号：US12504826

申请日：2009-07-17

Applicant: Steve RUBEN ,  Karen VAN ORDEN ,  Candy N. LEE ,  Tao HE ,  Mehdi MESRI ,  Elizabeth G. JOSELOFF ,  Paul MOORE ,  Katherine MCKINNON ,  Bruno DOMON

Inventor： Steve RUBEN ,  Karen VAN ORDEN ,  Candy N. LEE ,  Tao HE ,  Mehdi MESRI ,  Elizabeth G. JOSELOFF ,  Paul MOORE ,  Katherine MCKINNON ,  Bruno DOMON

IPC: A61K39/395 ,  C07K14/00 ,  A61K38/16 ,  C07H21/00 ,  C07H21/02 ,  C07K16/18 ,  C12N5/16 ,  C12N5/00 ,  G01N33/53 ,  C12N7/01 ,  A61P35/00

CPC classification number: G01N33/57484 ,  A61K38/00 ,  A61K47/6843 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/574 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2500/10 ,  Y10T436/143333

Abstract: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.

Abstract translation: 提供了与健康细胞相比，用于诊断和治疗与疾病细胞中癌症相关靶（CAT）不同表达相关的疾病，特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂，以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。

公开(公告)号：US20130111613A1

公开(公告)日：2013-05-02

申请号：US13621466

申请日：2012-09-17

Applicant: Yeounjin KIM ,  Tao HE ,  Steve RUBEN

Inventor： Yeounjin KIM ,  Tao HE ,  Steve RUBEN

IPC: C07K14/47 ,  G01N33/68 ,  C12Q1/68 ,  C07K16/18

CPC classification number: C07K16/18 ,  A61K39/0011 ,  A61K2039/55 ,  C07K14/47 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/57419 ,  G01N33/6893 ,  G01N2500/00

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US20170355752A1

公开(公告)日：2017-12-14

申请号：US15495398

申请日：2017-04-24

Applicant: Yeounjin KIM ,  Tao HE ,  Steve RUBEN

Inventor： Yeounjin KIM ,  Tao HE ,  Steve RUBEN

IPC: C07K16/18 ,  G01N33/68 ,  C12Q1/68 ,  C07K14/47 ,  A61K39/00 ,  C12N15/113 ,  G01N33/50 ,  G01N33/574

CPC classification number: C07K16/18 ,  A61K39/0011 ,  A61K2039/55 ,  C07K14/47 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/57419 ,  G01N33/6893 ,  G01N2500/00

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US20110212085A1

公开(公告)日：2011-09-01

申请号：US12859440

申请日：2010-08-19

Applicant: Elizabeth JOSELOFF ,  Aiqun LI ,  Tao HE ,  Steve RUBEN

Inventor： Elizabeth JOSELOFF ,  Aiqun LI ,  Tao HE ,  Steve RUBEN

IPC: A61K39/395 ,  C07K14/00 ,  A61K38/16 ,  C07H21/00 ,  C07H21/02 ,  C07K16/00 ,  C12N5/16 ,  C12N7/00 ,  G01N33/50 ,  G01N33/53 ,  A61P35/00

CPC classification number: G01N33/57423 ,  G01N2500/04 ,  Y10T436/143333

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and antibodies binds to LCATs. The present invention provides that LCATs are used as targets for screening agents that modulates the LCAT activities. Further the present invention provides methods for treating diseases associated with lung.

Abstract translation: 本发明提供了诊断和检测与肺相关疾病的方法。 本发明提供在肺部疾病（LCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合LCAT。 本发明提供LCAT作为调节LCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肺相关疾病的方法。

公开(公告)号：US20120076725A1

公开(公告)日：2012-03-29

申请号：US13005031

申请日：2011-01-12

Applicant: Charles BIRSE ,  Marcia LEWIS ,  Steve RUBEN ,  Mehdi MESRI

Inventor： Charles BIRSE ,  Marcia LEWIS ,  Steve RUBEN ,  Mehdi MESRI

IPC: G01N33/566 ,  A61P35/00 ,  A61K51/10 ,  C12Q1/68 ,  G01N21/64

CPC classification number: G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/8114 ,  G01N2333/96486 ,  G01N2800/56

Abstract: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods.

Abstract translation: 提供了使用肺癌标志物（LCM）评估（例如诊断），治疗和预防疾病，特别是癌症和特定肺癌的方法和组合物。 为这些和其他用途提供了单个LCM和包含多个LCM的面板。 还提供了用于确定或预测治疗的有效性或使用LCM选择治疗的方法和组合物。 还提供了使用LCM调节细胞功能的方法和组合物。 还提供了调节LCM的组合物（例如拮抗剂或激动剂），例如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义剂），以及其药物组合物。 还提供了筛选调节LCM的试剂的方法以及通过这些筛选方法鉴定的试剂。

公开(公告)号：US20210017259A1

公开(公告)日：2021-01-21

申请号：US16829400

申请日：2020-03-25

Applicant: Yeounjin KIM ,  Tao HE ,  Steve RUBEN

Inventor： Yeounjin KIM ,  Tao HE ,  Steve RUBEN

IPC: C07K16/18 ,  G01N33/574 ,  A61K39/00 ,  C07K14/47 ,  C12Q1/6886 ,  G01N33/68 ,  C12N15/113 ,  G01N33/50

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in colon diseases (CCAT) and antibodies binds to CCAT. The present invention provides that CCAT is used as targets for screening agents that modulates the CCAT activities. Further the present invention provides methods for treating diseases associated with colon.

公开(公告)号：US20120183552A1

公开(公告)日：2012-07-19

申请号：US13183696

申请日：2011-07-15

Applicant: Elizabeth JOSELOFF ,  Steve RUBEN ,  Tao HE ,  Yeounjin KIM

Inventor： Elizabeth JOSELOFF ,  Steve RUBEN ,  Tao HE ,  Yeounjin KIM

IPC: A61K39/395 ,  A61K39/00 ,  C12N15/12 ,  C07K16/18 ,  C07K16/46 ,  C07H21/02 ,  C12N5/02 ,  G01N33/53 ,  G01N33/48 ,  C12Q1/68 ,  C40B30/04 ,  C12N5/10 ,  C12N1/19 ,  A61P13/12 ,  C07K14/435

CPC classification number: C07K14/47 ,  A61K2039/505 ,  C07K14/435 ,  C07K16/18 ,  C07K16/3038 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6876 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/57438 ,  G01N33/57484 ,  G01N2333/47 ,  G01N2500/00 ,  G01N2500/10 ,  Y10T436/143333

Abstract: The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (KCAT) and antibodies binds to KCATs. The present invention provides that KCATs are used as targets for screening agents that modulates the KCAT activities. Further the present invention provides methods for treating diseases associated with kidney.

Abstract translation: 本发明提供了诊断和检测与肾相关的疾病的方法。 本发明提供在肾脏疾病（KCAT）中差异表达的一种或多种蛋白质或其片段，肽或核酸分子，并且抗体结合KCAT。 本发明提供KCAT作为调节KCAT活性的筛选剂的靶标。 此外，本发明提供了治疗与肾相关的疾病的方法。

公开(公告)号：US20110250204A1

公开(公告)日：2011-10-13

申请号：US12901254

申请日：2010-10-08

Applicant: Steve RUBEN ,  Paul A. MOORE ,  Tao HE ,  Candy N. LEE ,  Karen VAN ORDEN ,  Charles E. Birse ,  Mehdi Mesri ,  Elizabeth G. Joseloff

Inventor： Steve RUBEN ,  Paul A. MOORE ,  Tao HE ,  Candy N. LEE ,  Karen VAN ORDEN ,  Charles E. Birse ,  Mehdi Mesri ,  Elizabeth G. Joseloff

IPC: A61K39/395 ,  C07H21/02 ,  C07K16/00 ,  C07K16/18 ,  A61P35/00 ,  C12N5/071 ,  G01N33/53 ,  C12Q1/02 ,  A61K31/7088 ,  G01N33/68 ,  C07H21/04 ,  C12N5/16

CPC classification number: C07K16/3076 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/4748 ,  C07K14/705 ,  C07K14/70546 ,  C07K14/70596 ,  C07K16/18 ,  C07K16/2839 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/303 ,  C07K16/40 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/734 ,  C12N9/18 ,  C12N9/6424 ,  C12N15/113 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y301/01 ,  C12Y304/21 ,  C12Y304/21109 ,  G01N33/57488 ,  G01N33/57492

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract translation: 提供用于评估，治疗和预防使用癌症相关靶（CAT）的疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。