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    Method of preparing biodegradable dual pore polymer scaffolds for tissue engineering
    1.
    发明授权
    Method of preparing biodegradable dual pore polymer scaffolds for tissue engineering 有权
    制备用于组织工程的可生物降解双孔聚合物支架的方法

    公开(公告)号：US07842305B2

    公开(公告)日：2010-11-30

    申请号：US11526280

    申请日：2006-09-21

    申请人： Dong Keun Han ,  Kwang-Duk Ahn ,  Hyun Jung Jung ,  Kwideok Park

    发明人： Dong Keun Han ,  Kwang-Duk Ahn ,  Hyun Jung Jung ,  Kwideok Park

    IPC分类号： A61F2/00

    CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04

    摘要： There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of −196° C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol.According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.

    摘要翻译： 提供了一种制备可生物降解的双孔聚合物支架的方法，包括以下步骤：将含有可生物降解的聚合物，碳酸盐和有机酸的泡腾混合物和溶剂的聚合物溶液在-196℃的温度范围内保持至环境温度 温度以蒸发溶剂并产生聚合物样品; 并将聚合物样品在水和酒精的混合溶液中发泡。 根据本发明，与常规方法如盐浸技术，相分离技术或气体发泡技术相比，可以容易地控制聚合物支架的孔径，并且可以更简单地制备可生物降解的聚合物支架。 此外，由于根据本发明制备的可生物降解的聚合物支架具有高的表面积和孔隙率，而没有形成皮肤层，有毒物质的分泌和残留现象，因此它们可有利地用于组织工程中几乎所有活组织和器官的再生 。