公开(公告)号：US06339113B1

公开(公告)日：2002-01-15

申请号：US09698037

申请日：2000-10-30

Applicant: Dong-Keun Han ,  Kwang-Duk Ahn ,  Jong-Man Kim ,  Jin-Hee Jeong

Inventor： Dong-Keun Han ,  Kwang-Duk Ahn ,  Jong-Man Kim ,  Jin-Hee Jeong

IPC: C08F246

CPC classification number: C08F2/46 ,  A61K6/083 ,  C08F222/1006 ,  C08F2222/1046 ,  Y10S522/908 ,  C08F2222/1033 ,  C08F2222/1013 ,  C08L33/00

Abstract: The invention relates to a photopolymerizable composite resin composition for dental restoration i) based on the multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane (“Bis-GMA”) and multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in this Bis-GMA molecules, and ii) comprising a diluent, an inorganic filler, a photoinitiation system, and other additives. The photopolymerizable composite resin composition for dental restoration based on multifunctional prepolymer mixture has better physical and mechanical properties and biocompatibility than the conventional composition based on only Bis-GMA itself.

Abstract translation: 本发明涉及一种用于牙科修复的光聚合复合树脂组合物，i）基于2,2-双（4-（2-羟基-3-甲基丙烯酰氧基丙氧基）苯基）丙烷（“Bis-GMA”）和 通过在该Bis-GMA分子中用甲基丙烯酸酯基取代羟基中的氢原子形成的多官能预聚物，和ii）包含稀释剂，无机填料，光引发体系和其它添加剂。 基于多官能预聚物混合物的用于牙科修复的可光聚合复合树脂组合物比仅基于Bis-GMA本身的常规组合物具有更好的物理机械性能和生物相容性。

公开(公告)号：US5216087A

公开(公告)日：1993-06-01

申请号：US701888

申请日：1991-05-17

Applicant: Young-Ha Kim ,  Seo-Young Jeong ,  Kwang-Duk Ahn ,  Dong-Keun Han

Inventor： Young-Ha Kim ,  Seo-Young Jeong ,  Kwang-Duk Ahn ,  Dong-Keun Han

IPC: A61L33/00 ,  A61L33/06 ,  B01D67/00 ,  C08G18/08 ,  C08G18/10 ,  C08G18/83 ,  C08G65/22 ,  C08G65/334

CPC classification number: B01D67/0093 ,  A61L33/0082 ,  A61L33/068 ,  C08G18/0828 ,  C08G18/10 ,  C08G18/83 ,  C08G65/22 ,  C08G65/3344

Abstract: Novel sulfonated polyethyleneoxide-substituted polymers having improved blood compatibility are provided. The polymers are produced by substituting a polymeric substrate having active sites of amide or acid amide group, such as polyurethane, polyamide and polyacrylamide, with sulfonated polyethyleneoxide [PEO--(SO.sub.3 H).sub.n ].The polymers according to the present invention are valuable as construction materials of the artificial organs for the circulatory system in contact with blood, such as artificial hearts, artificial blood vessels, artificial kidneys, etc.

Abstract translation: 提供了具有改善的血液相容性的新型磺化聚环氧乙烷取代聚合物。 通过用具有磺化聚环氧乙烷[PEO-（SO 3 H）n]的氨基甲酸酯，聚酰胺和聚丙烯酰胺等具有酰胺或酰胺基团的活性位点的聚合物底物代替聚合物。 根据本发明的聚合物作为与血液接触的循环系统的人造器官如人造心脏，人造血管，人造肾等的建筑材料是有价值的。

公开(公告)号：US06861087B2

公开(公告)日：2005-03-01

申请号：US10270737

申请日：2002-10-16

Applicant: Dong Keun Han ,  Kwang Duk Ahn ,  Young Min Ju ,  Saeyoung Ahn

Inventor： Dong Keun Han ,  Kwang Duk Ahn ,  Young Min Ju ,  Saeyoung Ahn

IPC: C08J7/00 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L31/00 ,  B05D3/00

CPC classification number: A61L27/58 ,  A61L27/18 ,  A61L27/56 ,  C08L67/04

Abstract: A method for modifying surface of biodegradable porous polymer scaffold for tissue engineering using a low temperature plasma discharge apparatus, and particularly, a method for inducing the biodegradable porous polymer scaffold to be hydrophilic by graft polymerizing a hydrophilic monomer on the surface of the biodegradable porous polymer scaffold, which is made of polylactic acid, polyglycolic acid or poly(lactic acid-glycolic acid) copolymer, using a low temperature plasma. The surface-modified porous polymer scaffold according to the present invention has an enhanced cell compatibility in cell culture in vitro, and promote tissue growth when the cell is transplanted into a body.

Abstract translation: 一种使用低温等离子体放电装置改性组织工程用生物降解性多孔聚合物支架表面的方法，特别是通过在亲水性单体的表面上接枝聚合生物降解性多孔质聚合物而诱导亲水性的方法 支架，其由聚乳酸，聚乙醇酸或聚（乳酸 - 乙醇酸）共聚物制成，使用低温等离子体。 根据本发明的表面改性多孔聚合物支架在体外细胞培养中具有增强的细胞相容性，并且当细胞被移植到体内时促进组织生长。

公开(公告)号：US5116361A

公开(公告)日：1992-05-26

申请号：US534242

申请日：1990-06-07

Applicant: Young-Ha Kim ,  Seo-Young Jeong ,  Kwang-Duk Ahn ,  Dong-Keun Han

Inventor： Young-Ha Kim ,  Seo-Young Jeong ,  Kwang-Duk Ahn ,  Dong-Keun Han

IPC: A61L33/00 ,  A61L33/06 ,  B01D67/00 ,  C08G18/08 ,  C08G18/10 ,  C08G18/83 ,  C08G65/22 ,  C08G65/334

CPC classification number: B01D67/0093 ,  A61L33/0082 ,  A61L33/068 ,  C08G18/0828 ,  C08G18/10 ,  C08G18/83 ,  C08G65/22 ,  C08G65/3344

Abstract: Novel sulfonated polyethyleneoxide-substituted polymers having improved blood compatibility are provided. The polymers are produced by substituting a polymeric substrate having active sites of amide or acid amide group, such as polyurethane, polyamide and polyacrylamide, with sulfonated polyethyleneoxide PEO-SO.sub.3 H.The polymers according to the present invention are valuable as construction materials of the artificial organs for the circulatory system in contact with blood, such as artificial hearts, artificial blood vessels, artificial kidneys, etc.

Abstract translation: 提供了具有改善的血液相容性的新型磺化聚环氧乙烷取代聚合物。 聚合物通过用磺化聚环氧乙烷PEO-SO 3 H替代具有酰胺或酰胺基团的活性位点的聚合物底物，如聚氨酯，聚酰胺和聚丙烯酰胺。 根据本发明的聚合物作为与血液接触的循环系统的人造器官如人造心脏，人造血管，人造肾等的建筑材料是有价值的。

公开(公告)号：US07842305B2

公开(公告)日：2010-11-30

申请号：US11526280

申请日：2006-09-21

Applicant: Dong Keun Han ,  Kwang-Duk Ahn ,  Hyun Jung Jung ,  Kwideok Park

Inventor： Dong Keun Han ,  Kwang-Duk Ahn ,  Hyun Jung Jung ,  Kwideok Park

IPC: A61F2/00

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04

Abstract: There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of −196° C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol.According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.

Abstract translation: 提供了一种制备可生物降解的双孔聚合物支架的方法，包括以下步骤：将含有可生物降解的聚合物，碳酸盐和有机酸的泡腾混合物和溶剂的聚合物溶液在-196℃的温度范围内保持至环境温度 温度以蒸发溶剂并产生聚合物样品; 并将聚合物样品在水和酒精的混合溶液中发泡。 根据本发明，与常规方法如盐浸技术，相分离技术或气体发泡技术相比，可以容易地控制聚合物支架的孔径，并且可以更简单地制备可生物降解的聚合物支架。 此外，由于根据本发明制备的可生物降解的聚合物支架具有高的表面积和孔隙率，而没有形成皮肤层，有毒物质的分泌和残留现象，因此它们可有利地用于组织工程中几乎所有活组织和器官的再生 。

公开(公告)号：US20070092557A1

公开(公告)日：2007-04-26

申请号：US11526280

申请日：2006-09-21

Applicant: Dong Han ,  Kwang-Duk Ahn ,  Hyun Jung ,  Kwideok Park

Inventor： Dong Han ,  Kwang-Duk Ahn ,  Hyun Jung ,  Kwideok Park

IPC: A61K9/70 ,  B29C65/00

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/58 ,  C08L67/04

Abstract: There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of −196° C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol. According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.

Abstract translation: 提供了一种制备可生物降解的双孔聚合物支架的方法，包括以下步骤：将含有可生物降解的聚合物，碳酸盐和有机酸的泡腾混合物和溶剂的聚合物溶液保持在-196℃至环境温度 温度以蒸发溶剂并产生聚合物样品; 并将聚合物样品在水和酒精的混合溶液中发泡。 根据本发明，与常规方法如盐浸技术，相分离技术或气体发泡技术相比，可以容易地控制聚合物支架的孔径，并且可以更简单地制备可生物降解的聚合物支架。 此外，由于根据本发明制备的可生物降解的聚合物支架具有高的表面积和孔隙率，而没有形成皮肤层，有毒物质的分泌和残留现象，因此它们可有利地用于组织工程中几乎所有活组织和器官的再生 。

公开(公告)号：US06573312B2

公开(公告)日：2003-06-03

申请号：US09749878

申请日：2000-12-29

Applicant: Dong-Keun Han ,  Kwang-Duk Ahn ,  Jin-Hee Jeong

Inventor： Dong-Keun Han ,  Kwang-Duk Ahn ,  Jin-Hee Jeong

IPC: A61K6083

CPC classification number: C09D4/00 ,  A61K6/0017 ,  C08K5/08 ,  C08K5/175 ,  C08F222/20 ,  C08F222/1006 ,  C08L33/00

Abstract: The invention relates to a photo-cured dental pit and fissure sealant composition for caries prevention: i) based on the multifunctional prepolymer mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl)propane (“Bis-GMA”), which has conventionally been used as dental pit and fissure sealant for caries prevention, and a multifunctional prepolymer formed by substituting hydrogen atoms in hydroxyl group with methacrylate groups in the Bis-GMA molecules; and ii) comprising a diluent, an inorganic filler, a photoinitiation system, and other additives. The dental pit and fissure sealant composition of the present invention is based on a multifunctional prepolymer mixture and has better physical and mechanical properties and biocompatibility than a conventional composition based on Bis-GMA only.

公开(公告)号：US06310344B1

公开(公告)日：2001-10-30

申请号：US09297208

申请日：1999-04-27

Applicant: Dong Ky Shin ,  Hyo Sup Lee ,  Sang Youl Yoon ,  Sang Bong Kwon ,  Cheon Su Kang ,  Myung Hwan Oh ,  Kwang Duk Ahn ,  Tae Suk Park ,  Chong Hong Pyun ,  Byung Yong Yu

Inventor： Dong Ky Shin ,  Hyo Sup Lee ,  Sang Youl Yoon ,  Sang Bong Kwon ,  Cheon Su Kang ,  Myung Hwan Oh ,  Kwang Duk Ahn ,  Tae Suk Park ,  Chong Hong Pyun ,  Byung Yong Yu

IPC: H01T1900

CPC classification number: H01J9/2276 ,  G03G15/0291

Abstract: Disclosed is a wire-type corona charger having a wire electrode disposed between ground electrode plates. The wire electrode is supported by the ends of the plurality of wire electrode supporters which are so arranged that their ends have a curvature equal to arcuately-shaped upper edge of the ground electrode plates. The curvature coincides with one of the curvatures of the horizontal axis and the vertical axis of the interior surface of the panel faceplate, while the charger is pivoted along the other curvature of the faceplate. The charger can uniformly charge the photoconductive layer and improves the charging efficiency.

Abstract translation: 公开了一种线状电晕充电器，其具有设置在接地电极板之间的线电极。 线电极由多个线电极支撑体的端部支撑，多个线电极支撑体的端部被布置为使其端部具有等于接地电极板的弧形上边缘的曲率。 曲率与面板面板内表面的水平轴和垂直轴的曲率中的一个一致，同时充电器沿着面板的另一个曲率枢转。 充电器可以对光电导层进行均匀充电，提高充电效率。

公开(公告)号：US06562374B1

公开(公告)日：2003-05-13

申请号：US09699213

申请日：2000-10-27

Applicant: Dong Keun Han ,  Kwang-Duk Ahn ,  Jong-Man Kim ,  Young Min Ju

Inventor： Dong Keun Han ,  Kwang-Duk Ahn ,  Jong-Man Kim ,  Young Min Ju

IPC: C08J900

CPC classification number: C08J9/08 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  C08J9/28 ,  C08J2201/048 ,  C08J2367/04 ,  Y10S514/802 ,  Y10S514/945 ,  Y10S514/955 ,  C08L67/04

Abstract: The present invention provides a method for preparing biodegradable porous polymer scaffolds for tissue engineering, comprising: a) fabricating a polymer sample from a polymer solution containing at least one biodegradable polymer and an effervescent mixture; b) effervescing the polymer sample in the presence of an effervescent medium such as an aqueous alcohol solution; and c) drying. The method for preparing biodegradable polymer scaffolds of the present invention has the advantages that the process is simple, that pore size can be easily controlled, that the problem caused by the secretion and existence of the toxic substance can be avoid by using a material harmless to human body, and that high efficiency can be achieved. In addition, biodegradable porous polymer scaffolds prepared by above method have the advantages that high porosity can be achieved and an open cell structure in which pores are interconnected is obtained.

Abstract translation: 本发明提供了一种制备用于组织工程的可生物降解的多孔聚合物支架的方法，包括：a）从含有至少一种可生物降解的聚合物和泡腾混合物的聚合物溶液制备聚合物样品; b）在存在聚合物样品的情况下， 泡腾介质如醇水溶液; 和.c）干燥。本发明的可生物降解的聚合物支架的制备方法具有以下优点：该方法简单，可以容易地控制孔径，通过使用可以避免由分解和存在的有毒物质引起的问题 对人体无害的物质，可以实现高效率。 此外，通过上述方法制备的可生物降解的多孔聚合物支架具有能够获得高孔隙率并且获得孔互连的开孔结构的优点。

公开(公告)号：US06610457B2

公开(公告)日：2003-08-26

申请号：US09975967

申请日：2001-10-15

Applicant: Jun Young Kim ,  Sung Hyun Ha ,  Kwang Duk Ahn ,  Jong Hee Kang

Inventor： Jun Young Kim ,  Sung Hyun Ha ,  Kwang Duk Ahn ,  Jong Hee Kang

IPC: G03C176

CPC classification number: C08F220/30 ,  G03F7/091

Abstract: A bottom antireflective coating layer is made from the compositions of organic photosensitive materials that contain isoflavone chromophore by photolithography utilizing a deep ultraviolet light source for producing a submicro-level, large-scale integrated chip. A copolymer containing an isoflavone chromophore is used as a bottom antireflective coating layer for fabricating a 64-megabit or gigabit DRAM. The antireflective coating layer enables not only the suppression of reflections of light that occur under the substrate layer but also the removal of standing waves. Consequently, a high-resolution sub-micron of a 100˜200 nm integrated circuit is able to be stably formed. Therefore, it is possible to increase the production of semiconductors.

Abstract translation: 底部抗反射涂层由含有异黄酮发色团的有机感光材料的组合物由利用深紫外光源的光刻法制成亚微米级大型集成芯片制成。 含有异黄酮发色团的共聚物被用作用于制造64兆位或千兆位DRAM的底部抗反射涂层。 抗反射涂层不仅能够抑制在基底层下发生的光的反射，而且能够消除驻波。 因此，可以稳定地形成100〜200nm集成电路的高分辨率亚微米。 因此，可以增加半导体的生产。