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1.发明授权Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 有权可靠地达到可接受的血清睾酮水平的方法和药物组合物公开(公告)号：US07718640B2
公开(公告)日：2010-05-18
申请号：US10798780
申请日：2004-03-12
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K9/0019 , A61K31/56 , A61K31/568 , A61K31/57 , A61K47/14 , A61K47/44
摘要： The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositions according to a particular administration scheme, reliable levels of testosterone in serum in the normal physiological range is achieved for a long period. This allows for the use of the compositions in hormone replacement therapy and male contraception without concomitant monitoring of testosterone levels in serum by a physician.
摘要翻译： 本发明涉及配制用于可注射给药的药物组合物，其包含睾酮酯，特别是十一酸睾酮，载体包含蓖麻油和共溶剂。 在根据特定给药方案注射组合物时，长时间内可获得在正常生理范围内血清中可靠水平的睾丸激素。 这允许在激素替代治疗和男性避孕中使用组合物，而无需伴随地监测医师对血清中的睾酮水平。
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2.发明申请Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 有权可靠地达到可接受的血清睾酮水平的方法和药物组合物公开(公告)号：US20050032762A1
公开(公告)日：2005-02-10
申请号：US10798780
申请日：2004-03-12
IPC分类号： A61K9/00 , A61K31/56 , A61K31/565 , A61K31/568 , A61K31/57 , A61K36/47 , A61K47/14 , A61K47/44 , A61K35/78
CPC分类号： A61K31/565 , A61K9/0019 , A61K31/56 , A61K31/568 , A61K31/57 , A61K47/14 , A61K47/44
摘要： The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositions according to a particular administration scheme, reliable levels of testosterone in serum in the normal physiological range is achieved for a long period. This allows for the use of the compositions in hormone replacement therapy and male contraception without concomitant monitoring of testosterone levels in serum by a physician.
摘要翻译： 本发明涉及配制用于可注射给药的药物组合物，其包含睾酮酯，特别是十一酸睾酮，载体包含蓖麻油和共溶剂。 在根据特定给药方案注射组合物时，长时间内可获得在正常生理范围内血清中可靠水平的睾丸激素。 这允许在激素替代治疗和男性避孕中使用组合物，而无需伴随地监测医师对血清中的睾酮水平。
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