公开(公告)号：US20140342000A1

公开(公告)日：2014-11-20

申请号：US14367025

申请日：2012-12-12

申请人： Doris STEINMÜLLER-NETHL ,  DiaCoating GmbH

发明人： Doris Steinmüller-Nethl ,  Heike Walles

IPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/54

CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/303 ,  A61L27/42 ,  A61L27/443 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2400/12 ,  A61L2430/02

摘要： A biocompatible porous scaffolds, especially bone regeneration scaffolds, comprising carbon-based nanoparticles, especially diamond nanoparticles, methods for the production of such biocompatible porous scaffolds, the use of such biocompatible porous scaffolds and methods for treating bone defects by inserting such biocompatible porous scaffolds comprising carbon-based nanoparticles into the bone defect.

摘要翻译： 包括碳基纳米颗粒，特别是金刚石纳米颗粒的生物相容性多孔支架，特别是骨再生支架，用于生产这种生物相容性多孔支架的方法，使用这种生物相容性多孔支架和通过插入这种生物相容性多孔支架来治疗骨缺损的方法，包括 碳基纳米颗粒进入骨缺损。

公开(公告)号：US08753661B2

公开(公告)日：2014-06-17

申请号：US11792613

申请日：2005-12-07

申请人： Doris Steinmüller-Nethl ,  Detlef Steinmüller ,  Frank Rudolf Kloss ,  Robert Gassner ,  Günther Bonn ,  Christian Wolfgang Huck ,  Muhammed Najam-Ul-Haq ,  Matthias Rainer ,  Günther Stecher

发明人： Doris Steinmüller-Nethl ,  Detlef Steinmüller ,  Frank Rudolf Kloss ,  Robert Gassner ,  Günther Bonn ,  Christian Wolfgang Huck ,  Muhammed Najam-Ul-Haq ,  Matthias Rainer ,  Günther Stecher

IPC分类号： A61F2/00 ,  A61L27/30 ,  A61L27/54 ,  A61L29/10 ,  A61L29/16 ,  A61L31/08

CPC分类号： A61L27/303 ,  A61L27/54 ,  A61L29/103 ,  A61L29/16 ,  A61L31/084

摘要： A base body contains a substrate that is at least partially coated with a carbon-containing layer. The carbon-containing layer is at least partially functionalized with a molecule that is bound directly or via at least one linker or functional group to the carbon-containing layer. The base body, which has a functionalized carbon-containing surface, is capable of influencing biological processes during a corresponding functionalization.

摘要翻译： 基体包含至少部分地涂覆有含碳层的基材。 含碳层至少部分地被直接结合或通过至少一个与含碳层的接头或官能团结合的分子官能化。 具有官能化含碳表面的基体能够在相应的官能化过程中影响生物过程。

公开(公告)号：US20100184062A1

公开(公告)日：2010-07-22

申请号：US12667583

申请日：2008-07-04

申请人： Doris Steinmüller-Nethl ,  Anton Köck ,  Detlef Steinmüller ,  Kriemhilt Roppert

发明人： Doris Steinmüller-Nethl ,  Anton Köck ,  Detlef Steinmüller ,  Kriemhilt Roppert

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6825 ,  G01N33/5438 ,  C12Q2565/543 ,  C12Q2537/162

摘要： The invention relates to a method for identifying organic or biochemical substances and for determining their concentration in a fluid medium using a nanogap sensor that comprises at least two electrodes. The invention is characterized in that: a nanogap sensor) with electrodes of different materials is used, a respective probe molecule is bonded to each surface of the two electrodes of the sensor and the free remainder of the probe molecules have at least one bondable group with specificity for bonding to a sought substance or to an analyte molecule in the fluid medium. The analyte molecule has at least two binding sites and passes selectively out of the fluid medium in which it is contained, binds to the free ends of the probe molecules, forming a bridge with the probe molecule, and modifies the resulting impedance between the electrodes. The concentration of the substance in the fluid medium can be determined as a result of the modification.

摘要翻译： 本发明涉及用于鉴别有机或生物化学物质并使用包含至少两个电极的纳米隙传感器来测定其在流体介质中的浓度的方法。 本发明的特征在于：使用具有不同材料的电极的纳米隙传感器），将相应的探针分子结合到传感器的两个电极的每个表面，并且探针分子的游离剩余部分具有至少一个可结合的基团， 与所寻求的物质或流体介质中的分析物分子结合的特异性。 分析物分子具有至少两个结合位点，并且选择性地从其所含的流体介质中流出，与探针分子的自由端结合，与探针分子形成桥，并修改电极之间产生的阻抗。 流体介质中物质的浓度可以作为修改的结果来确定。