专利检索 ap:("DoubleRainbow Biosciences Inc.") AND inv:"Sheng Ding" 第 1 页

1.

发明申请
Ivacaftor Glycosides, Methods Of Making, And Uses Thereof In Treating Cystic Fibrosis 有权

公开(公告)号：US20230124589A1

公开(公告)日：2023-04-20

申请号：US17906396

申请日：2021-03-15

申请人： DoubleRainbow Biosciences Inc.

发明人： Sheng Ding , Yasmin-Pei Kamal Chau , Jacob Donald Stanley Wirth , Tian Xu , Jing-Ke Weng

IPC分类号： C12P19/60 , C12N9/10 , A61K47/61 , A61K47/54

摘要： Ivacaftor glycosides and methods of making ivacaftor glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to ivacaftor to yield ivacaftor glycosides. Suitable monosaccharides can be in the L- or D-configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, glucose, glucuronic acid, mannose, A-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.

2.

发明公开
Etoposide Glycosides, Methods Of Making, And Uses Thereof As An Anti-Cancer Drug 审中-公开

公开(公告)号：US20230192748A1

公开(公告)日：2023-06-22

申请号：US17906373

申请日：2021-03-15

申请人： DoubleRainbow Biosciences Inc.

发明人： Sheng Ding , Yasmin-Pei Chau , Jacob Donald Stanley Wirth , Tian Xu , Jing-Ke Weng

IPC分类号： C07H17/04

CPC分类号： C07H17/04

摘要： Etoposide glycosides and methods of making etoposide glycosides are disclosed. Glycosyl transferases catalyze addition of one or more monosaccharides to etoposide to yield etoposide glycosides. Suitable monosaccharides can be in the L- or D-configuration and typically have 5, 6, or 7 carbons. Suitable monosaccharides include allose, apiose, arabinose, fructose, fucitol, fucose, galactose, glucose, glucuronic acid, mannose, A-acetylglucosamine, rhamnose, or xylose. Uridine diphosphate glycosyl transferases can catalyze formation of either an alpha or beta glycosidic bond.