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1.发明授权Combination of electrogram and intra-cardiac pressure to discriminate between fibrillation and tachycardia 有权电图和心脏内压力的组合来区分原纤维性颤动和心动过速公开(公告)号：US07233822B2
公开(公告)日：2007-06-19
申请号：US10881541
申请日：2004-06-29
IPC分类号： A61B5/04
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61B5/0464 , A61B5/7257 , A61B5/7264 , A61N1/3622 , A61N1/36564 , A61N1/3956
摘要： A system and method for detecting and classifying cardiac arrhythmias based on cardiac pressure signals or the combination of cardiac electrical and cardiac pressure signals. A cardiac electrogram signal is sensed to derive a cardiac rate from which an arrhythmia detection is made when the cardiac rate meets arrhythmia detection criteria. An intracardiac pressure signal is sensed to derive an indicator of tachycardia based on an analysis of the pressure signal in either the time domain or frequency domain. The detected arrhythmia is classified as tachycardia or fibrillation based on the tachycardia indicator wherein the tachycardia indicator is compared to tachycardia detection criteria and the arrhythmia is classified as tachycardia if tachycardia detection criteria are met and the arrhythmia is classified as fibrillation if the tachycardia detection criteria are not met.
摘要翻译： 一种基于心脏压力信号或心脏电压和心脏压力信号的组合来检测和分类心律失常的系统和方法。 感测到心电图信号以导出当心率达到心律失常检测标准时进行心律失常检测的心率。 基于对时域或频域中的压力信号的分析，感测心内压力信号以导出心动过速的指标。 检测到的心律失常根据心动过速指标分类为心动过速指标，其中心动过速指标与心动过速检测标准进行比较，如果心动过速检测标准得到满足，则将心律不齐分类为心动过速，如果心动过速检测标准为 没见过。
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公开(公告)号：US20100023079A1
公开(公告)日：2010-01-28
申请号：US12178534
申请日：2008-07-23
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： A method and apparatus is provided for determining whether a current atrial-ventricular (AV) delay during cardiac pacing is appropriate for proper mechanical coupling of the atrium and ventricle. If proper mechanical coupling is determined to not exist, an additional atrial contraction is induced within the same ventricular cycle to maintain atrial-ventricular mechanical coupling.
摘要翻译： 提供了一种用于确定心脏起搏期间当前心房（AV）延迟是否适合于心房和心室的适当机械耦合的方法和装置。 如果确定不存在适当的机械耦合，则在相同心室周期内诱发另外的心房收缩以维持心房 - 心室机械耦合。
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公开(公告)号：US09375578B2
公开(公告)日：2016-06-28
申请号：US12178534
申请日：2008-07-23
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3682
摘要： A method and apparatus is provided for determining whether a current atrial-ventricular (AV) delay during cardiac pacing is appropriate for proper mechanical coupling of the atrium and ventricle. If proper mechanical coupling is determined to not exist, an additional atrial contraction is induced within the same ventricular cycle to maintain atrial-ventricular mechanical coupling.
摘要翻译： 提供了一种用于确定心脏起搏期间当前心房（AV）延迟是否适合于心房和心室的适当机械耦合的方法和装置。 如果确定不存在适当的机械耦合，则在相同心室周期内诱发另外的心房收缩以维持心房 - 心室机械耦合。
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4.发明授权System and method for using atrial pacing to enhance function of stunned atrial myocardium following conversion to normal sinus rhythm 有权使用心房起搏来改善正常窦性心律后震颤心房心肌功能的系统和方法公开(公告)号：US08700155B2
公开(公告)日：2014-04-15
申请号：US11095846
申请日：2005-03-31
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/046 , A61N1/3627 , A61N1/36514 , A61N1/36557 , A61N1/36564 , A61N1/3962
摘要： An implantable medical device (IMD) having a therapy circuit for delivering atrial pacing and a control circuit for detecting a return to sinus rhythm. The control circuit determines the duration of an atrial arrhythmia preceding the return to sinus rhythm, and controls the therapy circuit to deliver transient atrial pacing based on the atrial arrhythmia duration.
摘要翻译： 一种具有用于递送心房起搏的治疗电路和用于检测回到窦性心律的控制电路的可植入医疗装置（IMD）。 控制电路确定返回到窦性心律之前的心房心律失常的持续时间，并且控制治疗电路基于心房心律失常持续时间递送瞬时心房起搏。
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公开(公告)号：US07792581B2
公开(公告)日：2010-09-07
申请号：US11363729
申请日：2006-02-28
IPC分类号： A61N1/365
CPC分类号： A61N1/3627
摘要： Methods and systems for treating patients with diastolic heart failure (DHF) are disclosed which include slowing a patient's heart rate below its intrinsic rate, and controlling the rate using cardiac pacing therapy to improve LV filling and cardiac output. In certain embodiments, a pacing treatment rate may be determined by adjusting an adaptive rate by an amount determined by evaluating one or more patient parameters.
摘要翻译： 公开了用于治疗舒张性心力衰竭（DHF）患者的方法和系统，其包括将患者的心率降低到其内在速率以下，并且使用心脏起搏治疗来控制速率以改善LV灌注和心输出量。 在某些实施例中，起搏治疗率可以通过将自适应速率调整到通过评估一个或多个患者参数确定的量来确定。
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6.发明授权Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权基于血流动力学传感器反馈控制心房除颤治疗公开(公告)号：US07336994B2
公开(公告)日：2008-02-26
申请号：US10760155
申请日：2004-01-16
申请人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
发明人： Douglas A. Hettrick , David E. Euler , Eduardo N. Warman , Michael R. Ujhelyi , Rahul Mehra , Paul D. Ziegler , Shailesh Kumar V. Musley , Charles E. Distad , David E. Ritscher
IPC分类号： A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译： 公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。 血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。 具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。 因此，对于血液动力学良性心律失常，禁止使用除颤疗法。
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7.发明授权Method and apparatus for evaluating ventricular performance during isovolumic contraction 有权在等容收缩期间评估心室性能的方法和装置公开(公告)号：US07233821B2
公开(公告)日：2007-06-19
申请号：US11097706
申请日：2005-03-31
CPC分类号： A61N1/3627 , A61B8/0858 , A61N1/36528 , A61N1/3684
摘要： A method of evaluating ventricular performance of a heart employing sensors to measure a ventricular dimension signal and deriving indices of ventricular performance therefrom. Premature Shortening (PS) and Isovolumic Lengthening (IL) comprise two indices of ventricular performance determined from analysis of the left ventricular dimension signal during the transition from ventricular filling to ventricular ejection. Measured values of PS and IL are compared to other measured values or reference values to determine if ventricular performance has improved (or worsened). In some embodiments, the dimension sensors may comprise piezoelectric sonomicrometer crystals that operate as ultrasound transmitters and receivers. The sensors may be mounted in relation to a ventricle of the heart either temporarily or permanently, and may be configured either separately from or integrally with cardiac pacing leads.
摘要翻译： 评估使用传感器测量心室尺寸信号并从其导出心室性能指数的心脏心室性能的方法。 过早缩短（PS）和等压延长（IL）包括从心室充填到心室射血的过渡期间从左心室尺寸信号的分析确定的两个心室指数指数。 将PS和IL的测量值与其他测量值或参考值进行比较，以确定心室性能是否改善（或恶化）。 在一些实施例中，尺寸传感器可以包括作为超声波发射器和接收器操作的压电经济测量晶体。 传感器可以相对于心脏的心室临时或永久地安装，并且可以与心脏起搏引线分开地或与心脏起搏引线一体地配置。
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8.发明授权公开(公告)号：US09370654B2
公开(公告)日：2016-06-21
申请号：US12360680
申请日：2009-01-27
申请人： Avram Scheiner , David E. Euler
发明人： Avram Scheiner , David E. Euler
CPC分类号： A61N1/0556 , A61B5/4035 , A61B5/4047 , A61B5/7217 , A61N1/36114
摘要： An implantable medical device and associated method deliver a therapy to an autonomic nerve. The therapy delivery includes delivering therapeutic low frequency (LF) electrical stimulation pulses to the autonomic nerve and delivering a high frequency electrical signal to the autonomic nerve during the LF frequency stimulation pulse delivery. The high frequency stimulation signal blocks activation of autonomic nerve fibers innervating a non-targeted tissue during the therapeutic LF stimulation pulse delivery.
摘要翻译： 可植入医疗装置和相关方法将治疗递送至自主神经。 治疗递送包括在LF频率刺激脉冲传送期间向自主神经递送治疗性低频（LF）电刺激脉冲并将高频电信号传送到自主神经。 高频刺激信号阻止在治疗性LF刺激脉冲输送期间支配非目标组织的自主神经纤维的活化。
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公开(公告)号：US07835789B2
公开(公告)日：2010-11-16
申请号：US11379904
申请日：2006-04-24
申请人： David E. Euler
发明人： David E. Euler
IPC分类号： A61N1/362
CPC分类号： A61N1/36514 , A61N1/3627
摘要： Implantable pulse generators (IPGs) are adapted to deliver stimulation to refractory myocardial tissue. An IPG nominally delivers one to six monophasic stimulation pulses. Because monophasic stimulation tends to accumulate polarization, a programmable blanking period of between about 20 milliseconds (ms) and about 300 ms is implemented (subsequent to delivery of the last pulse in a RPS pulse train) to allow recovery from polarization. The stimulation pulse width is about 0.03 ms to about 1.6 ms and voltage amplitude of 0.5 volts to 8 volts at about 50 Hz. The amplitude of electrical current of the stimulation pulses is less than or equal to approximately 50 milliamps. The pulses are delivered to multiple sites within a cardiac chamber and device performance and/or diagnostic information can be stored within a memory structure and reviewed to confirm delivery of a desired therapy regimen.
摘要翻译： 植入式脉冲发生器（IPG）适用于将难度增加的心肌组织刺激。 IPG名义上提供一到六个单相刺激脉冲。 因为单相刺激倾向于积聚极化，所以实现约20毫秒（ms）到约300ms之间的可编程消隐周期（在RPS脉冲串中传送最后一个脉冲之后）以允许从极化恢复。 刺激脉冲宽度为约0.03ms至约1.6ms，在约50Hz下的电压振幅为0.5伏至8伏。 刺激脉冲的电流幅度小于或等于约50毫安。 将脉冲输送到心室内的多个部位，并且将装置性能和/或诊断信息存储在存储器结构内并进行审查，以确认所需治疗方案的递送。
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公开(公告)号：US09149638B2
公开(公告)日：2015-10-06
申请号：US11343175
申请日：2006-01-30
CPC分类号： A61N1/3627 , A61N1/36564
摘要： A method of controlling pulmonary capillary pressure is disclosed which includes increasing the output of a first ventricle (V1) (e.g., a left ventricle) relative to second ventricle (e.g., right ventricle) by increasing the magnitude of a post extrasystolic potentiation (PESP) therapy effect in the first ventricle relative to the magnitude of a PESP therapy effect produced in the second ventricle. In certain embodiments of the invention, this may be accomplished by adjusting the extra-stimulus interval (ESI) in either or both of the left ventricle and the right ventricle, for example.
摘要翻译： 公开了一种控制肺毛细血管压力的方法，其包括通过增加收缩后增强功能（PESP）的幅度来增加相对于第二脑室（例如，右心室）的第一脑室（V1）（例如，左心室）的输出， 相对于在第二脑室产生的PESP治疗效果的大小，第一脑室的治疗效果。 在本发明的某些实施方案中，例如可以通过调整左心室和右心室中的任一者或两者的额外刺激间隔（ESI）来实现。
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