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    Targeting drug/gene carriers to irradiated tissue
    1.
    发明授权
    Targeting drug/gene carriers to irradiated tissue 失效
    将药物/基因载体靶向辐照的组织

    公开(公告)号：US07182933B2

    公开(公告)日：2007-02-27

    申请号：US09975899

    申请日：2001-10-12

    申请人： Douglas J. Goetz ,  Mohammad F. Kiani

    发明人： Douglas J. Goetz ,  Mohammad F. Kiani

    IPC分类号： A61K49/00 ,  A61K39/395 ,  A61K9/27

    CPC分类号： A61K9/5153 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2821

    摘要： The present invention provides a biomolecular carrier of pharmaceuticals, comprising: a biomolecule carrier bearing molecules that bind to a cellular adhesion molecule expressed on endothelial cell; and a pharmaceutical. The present invention also provides a method of treating a pathophysiological state in an individual in need of such treatment, comprising the steps of: irradiating a target tissue or organ in said individual; and administering to said individual the biomolecular carrier disclosed herein.

    摘要翻译： 本发明提供了一种药物的生物分子载体，其包含：携带分子的生物分子载体，其结合在内皮细胞上表达的细胞粘附分子; 和制药。 本发明还提供一种治疗需要这种治疗的个体的病理生理状态的方法，包括以下步骤：照射所述个体中的靶组织或器官; 并向所述个体施用本文公开的生物分子载体。

    Sheet metal washer having washer cassette mountable on tank
    2.
    发明授权
    Sheet metal washer having washer cassette mountable on tank 有权
    钣金垫圈，垫圈可安装在油罐上

    公开(公告)号：US06802324B2

    公开(公告)日：2004-10-12

    申请号：US10744557

    申请日：2003-12-23

    申请人： William Robert Budry, Jr. ,  Mohamad A. Sebai ,  Douglas J. Goetz ,  David Berghorn ,  Michael J. Bleau

    发明人： William Robert Budry, Jr. ,  Mohamad A. Sebai ,  Douglas J. Goetz ,  David Berghorn ,  Michael J. Bleau

    IPC分类号： B08B301

    CPC分类号： C23G3/00 ,  B08B3/022

    摘要： A sheet metal washer system for cleaning metal blanks includes a washer cassette with an open bottom that is selectively mounted on a tank assembly, a drive motor assembly and a filter assembly. The washer cassette includes an inlet opening and an exit opening with upper and lower entry rollers having a first predetermined durometer positioned adjacent to the inlet opening and upper and lower exit rollers having a second predetermined durometer positioned adjacent the exit opening. Upper and lower manifolds for delivering cleaning fluid from the filter assembly to the interior of the washer cassette are positioned between the entry and exit rollers. The sheet metal blank is cleaned by the entry rollers and dried by the exit rollers, as it passes through the sheet metal washer. The washer cassette preferably includes a safety mechanism for locking the upper entry and exit rollers into a storage position when the washer system is not in use. The washer cassette preferably further includes at least one quick disconnect air and fluid connection plate to permit one-step removal of all air and fluid lines from the washer cartridge. An optional exit spray system for coating the sheet metal blanks after being cleaned may be integrated within the washer cassette.

    摘要翻译： 用于清洁金属坯料的金属板清洗机系统包括具有开口底部的洗衣机盒，其被选择性地安装在罐组件上，驱动马达组件和过滤器组件。 洗衣机盒包括入口和出口，具有上和下入口辊，其具有邻近入口开口定位的第一预定硬度，以及具有邻近出口定位的第二预定硬度的上出口辊和下排出辊。 用于将清洁流体从过滤器组件传送到垫圈盒的内部的上歧管和下歧管定位在入口和出口辊之间。 钣金坯料通过入口辊清洁，并在出口辊通过金属垫圈时被出口辊干燥。 垫圈盒优选地包括安全机构，用于当洗衣机系统不使用时将上进出辊锁定到储存位置。 洗衣机盒优选地还包括至少一个快速断开的空气和流体连接板，以允许从垫圈筒一步地去除所有空气和流体管线。 用于在清洁之后涂覆金属板坯料的可选的出口喷射系统可以集成在洗衣机盒内。

    Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
    3.
    发明申请
    Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression 有权
    苯甲嘧啶，甲巯咪唑衍生物和互变异构环状硫堇用于治疗与同样受体过表达相关的自身免疫/炎性疾病

    公开(公告)号：US20120238610A1

    公开(公告)日：2012-09-20

    申请号：US13370079

    申请日：2012-02-09

    申请人： Leonard D. Kohn ,  Norikazu Harii ,  Uruguaysito Benavides-Peratta ,  Mariana Gonzalez-Murguiondo ,  Christopher J. Lewis ,  Douglas J. Goetz

    发明人： Leonard D. Kohn ,  Norikazu Harii ,  Uruguaysito Benavides-Peratta ,  Mariana Gonzalez-Murguiondo ,  Christopher J. Lewis ,  Douglas J. Goetz

    IPC分类号： A61K31/4164 ,  A61P31/00 ,  A61P29/00 ,  A61P31/04

    CPC分类号： A61K31/4164 ,  A61K31/4166 ,  A61K31/56 ,  A61K45/06 ,  Y02A50/411

    摘要： Treatment of autoimmune and/or inflammatory diseases associated with overexpression of Toll-like receptor 3 (TLR3) as well as Toll-like receptor 4 (TLR4) and/or TLR3/TLR4 signaling in nonimmune cells, monocytes, macrophages, and/or dendritic cells in association with related pathologies. The use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune and inflammatory diseases associated with TLR3 as well as TLR4 and/or TLR3/TLR4 cellular signaling in association with related pathologies is disclosed. Methods of treating a subject having a disease or condition associated with abnormal TLR-3 as well as TLR-4 and/or TLR3/TLR4 cellular signaling in association with related pathologies are also disclosed. The present disclosure also relates to the treatment of autoimmune-inflammatory pathologies and chemokine and cytokine-mediated diseases associated with TLR overexpression and signaling. The disclosure also relates to pharmaceutical formulations capable of inhibiting the IRF-3/Type 1 IFN/STAT/ISRE/IRF-1 pathway associated with Toll-like receptor overexpression or signaling.

    摘要翻译： 治疗与非免疫细胞，单核细胞，巨噬细胞和/或树突状细胞中Toll样受体3（TLR3）以及Toll样受体4（TLR4）和/或TLR3 / TLR4信号传导过度表达相关的自身免疫和/或炎性疾病 细胞与相关病理相关。 公开了使用苯基甲基咪唑，甲巯咪唑衍生物和互变异构环状硫for素治疗与TLR3相关的自身免疫性和炎症性疾病以及与相关病理学有关的TLR4和/或TLR3 / TLR4细胞信号传导。 还公开了治疗具有与异常TLR-3以及与相关病理学相关的TLR-4和/或TLR3 / TLR4细胞信号传导相关疾病或病症的受试者的方法。 本公开还涉及治疗与TLR过表达和信号传导相关的自身免疫性炎症病症和趋化因子和细胞因子介导的疾病。 本公开还涉及能够抑制与Toll样受体过表达或信号传导相关的IRF-3/1型IFN / STAT / ISRE / IRF-1途径的药物制剂。

    Sheet metal washer including tank assembly and washer cassette mounted on the tank assembly
    6.
    发明授权
    Sheet metal washer including tank assembly and washer cassette mounted on the tank assembly 失效
    钣金洗衣机，包括安装在油箱组件上的油箱组件和垫圈

    公开(公告)号：US06886574B2

    公开(公告)日：2005-05-03

    申请号：US10744559

    申请日：2003-12-23

    申请人： William Robert Budry, Jr. ,  Mohamad A. Sebai ,  Douglas J. Goetz ,  David Berghorn ,  Michael J. Bleau

    发明人： William Robert Budry, Jr. ,  Mohamad A. Sebai ,  Douglas J. Goetz ,  David Berghorn ,  Michael J. Bleau

    IPC分类号： B08B3/02 ,  C23G3/00

    CPC分类号： C23G3/00 ,  B08B3/022

    摘要： A sheet metal washer system for cleaning metal blanks includes a washer cassette with an open bottom that is selectively mounted on a tank assembly, a drive motor assembly and a filter assembly. The washer cassette includes an inlet opening and an exit opening with upper and lower entry rollers having a first predetermined durometer positioned adjacent to the inlet opening and upper and lower exit rollers having a second predetermined durometer positioned adjacent the exit opening. Upper and lower manifolds for delivering cleaning fluid from the filter assembly to the interior of the washer cassette are positioned between the entry and exit rollers. The sheet metal blank is cleaned by the entry rollers and dried by the exit rollers, as it passes through the sheet metal washer. The washer cassette preferably includes a safety mechanism for locking the upper entry and exit rollers into a storage position when the washer system is not in use. The washer cassette preferably further includes at least one quick disconnect air and fluid connection plate to permit one-step removal of all air and fluid lines from the washer cartridge. An optional exit spray system for coating the sheet metal blanks after being cleaned may be integrated within the washer cassette.

    摘要翻译： 用于清洁金属坯料的金属板清洗机系统包括具有开口底部的洗衣机盒，其被选择性地安装在罐组件上，驱动马达组件和过滤器组件。 洗衣机盒包括入口和出口，具有上和下入口辊，其具有邻近入口开口定位的第一预定硬度，以及具有邻近出口定位的第二预定硬度的上出口辊和下排出辊。 用于将清洁流体从过滤器组件传送到垫圈盒的内部的上歧管和下歧管定位在入口和出口辊之间。 钣金坯料通过入口辊清洁，并在出口辊通过金属垫圈时被出口辊干燥。 垫圈盒优选地包括安全机构，用于当洗衣机系统不使用时将上进出辊锁定到储存位置。 洗衣机盒优选地还包括至少一个快速断开的空气和流体连接板，以允许从垫圈筒一步地去除所有空气和流体管线。 用于在清洁之后涂覆金属板坯料的可选的出口喷射系统可以集成在洗衣机盒内。

    METHODS AND COMPOSITIONS FOR THE TREATMENT OF MALIGNANT MELANOMA, BREAST, PROSTATE, COLON, PAPILLARY THYROID AND PANCREATIC CANCER
    7.
    发明申请
    METHODS AND COMPOSITIONS FOR THE TREATMENT OF MALIGNANT MELANOMA, BREAST, PROSTATE, COLON, PAPILLARY THYROID AND PANCREATIC CANCER 审中-公开
    治疗恶性血友病，乳腺癌，前列腺癌，结肠癌，毛细血管癌和胰腺癌的方法和组合物

    公开(公告)号：US20100004304A1

    公开(公告)日：2010-01-07

    申请号：US12286880

    申请日：2008-10-01

    申请人： Leonard D. Kohn ,  Douglas J. Goetz ,  Kelly D. McCall ,  Anthony Schwartz ,  Frank Schwartz ,  Ramiro Malgor ,  Glorglo Napolitano ,  Cesidio Giullant

    发明人： Leonard D. Kohn ,  Douglas J. Goetz ,  Kelly D. McCall ,  Anthony Schwartz ,  Frank Schwartz ,  Ramiro Malgor ,  Glorglo Napolitano ,  Cesidio Giullant

    IPC分类号： A61K31/4164 ,  C12N5/06

    CPC分类号： A61K31/4166 ,  A61K31/4164

    摘要： It is now recognized that chronic inflammation is an important risk factor for the development of cancer. The proinflammatory cytokine IL-6 is implicated in cancer because it is important for the activation of STAT, a key regulator of cancer growth, survival, metastasis, immune evasion and angiogenesis. Increased IL-6 and Stat-3 exists in vitro in pancreatic cancer, malignant melanoma, papillary thyroid cancer, breast cancer, colon cancer, and prostate cancer cells with high basal expression of Toll-like receptor 3 (TLR3) and Wnt5a. IL6/STAT3 activation, mediated by overexpressed TLR3 signaling, appears important in the tumor growth process, it may increase Wnt5a signaling, and be associated with increased cellular growth and migration. Using a novel inhibitor of pathologic TLR3 signaling (5-phenylmethimazole [C10]) we have demonstrated decreases in these markers plus suppression of cell growth and migration in human pancreatic cancer, malignant melanoma, papillary thyroid cancer, breast cancer, colon cancer, and prostate cancer cells.

    摘要翻译： 现在认识到慢性炎症是癌症发展的重要危险因素。 促炎细胞因子IL-6涉及癌症，因为它对于STAT的活化是重要的，STAT是癌症生长，存活，转移，免疫逃避和血管生成的关键调节剂。 在胰腺癌，恶性黑素瘤，乳头状甲状腺癌，乳腺癌，结肠癌和前列腺癌细胞中，增加的IL-6和Stat-3在Toll样受体3（TLR3）和Wnt5a具有高基础表达。 由过表达的TLR3信号传导介导的IL6 / STAT3激活在肿瘤生长过程中似乎很重要，它可能增加Wnt5a信号传导，并且与增加的细胞生长和迁移相关。 使用新型的病理性TLR3信号抑制剂（5-苯基咪唑[C10]），我们已经证明这些标志物的减少加上抑制人胰腺癌，恶性黑素瘤，乳头状甲状腺癌，乳腺癌，结肠癌和前列腺癌细胞生长和迁移 癌细胞。

    Sheet metal blank washer system
    8.
    发明授权
    Sheet metal blank washer system 有权
    钣金冲压系统

    公开(公告)号：US06701945B1

    公开(公告)日：2004-03-09

    申请号：US09514834

    申请日：2000-02-28

    申请人： William Robert Budry, Jr. ,  Mohamad A. Sebai ,  Douglas J. Goetz ,  David Berghorn ,  Michael J. Bleau

    发明人： William Robert Budry, Jr. ,  Mohamad A. Sebai ,  Douglas J. Goetz ,  David Berghorn ,  Michael J. Bleau

    IPC分类号： B08B302

    CPC分类号： C23G3/00 ,  B08B3/022

    摘要： A sheet metal washer system for cleaning metal blanks includes a washer cassette with an open bottom that is selectively mounted on a tank assembly, a drive motor assembly and a filter assembly. The washer cassette includes an inlet opening and an exit opening with upper and lower entry rollers having a first predetermined durometer positioned adjacent to the inlet opening and upper and lower exit rollers having a second predetermined durometer positioned adjacent the exit opening. Upper and lower manifolds for delivering cleaning fluid from the filter assembly to the interior of the washer cassette are positioned between the entry and exit rollers. The sheet metal blank is cleaned by the entry rollers and dried by the exit rollers, as it passes through the sheet metal washer. The washer cassette preferably includes a safety mechanism for locking the upper entry and exit rollers into a storage position when the washer system is not in use. The washer cassette preferably further includes at least one quick disconnect air and fluid connection plate to permit one-step removal of all air and fluid lines from the washer cartridge. An optional exit spray system for coating the sheet metal blanks after being cleaned may be integrated within the washer cassette.

    摘要翻译： 用于清洁金属坯料的金属板清洗机系统包括具有开口底部的洗衣机盒，其被选择性地安装在罐组件上，驱动马达组件和过滤器组件。 洗衣机盒包括入口和出口，具有上和下入口辊，其具有邻近入口开口定位的第一预定硬度，以及具有邻近出口定位的第二预定硬度的上出口辊和下排出辊。 用于将清洁流体从过滤器组件传送到垫圈盒的内部的上歧管和下歧管定位在入口和出口辊之间。 钣金坯料通过入口辊清洁，并在出口辊通过金属垫圈时被出口辊干燥。 垫圈盒优选地包括安全机构，用于当洗衣机系统不使用时将上进出辊锁定到储存位置。 洗衣机盒优选地还包括至少一个快速断开的空气和流体连接板，以允许从垫圈筒一步地去除所有空气和流体管线。 用于在清洁之后涂覆金属板坯料的可选的出口喷射系统可以集成在洗衣机盒内。