公开(公告)号：US09649278B2

公开(公告)日：2017-05-16

申请号：US14350535

申请日：2012-10-09

Applicant: Dow Global Technologies LLC

Inventor： Michael D. Read ,  Karen A. Coppens ,  Mark J. Hall ,  Jin Zhao

IPC: A61K9/48 ,  C08L1/28 ,  C08L5/00

CPC classification number: A61K9/4816 ,  A61K9/4833 ,  A61K9/4883 ,  C08K5/0016 ,  C08K5/05 ,  C08L1/28 ,  C08L1/286 ,  C08L5/00

Abstract: An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

公开(公告)号：US20190209693A1

公开(公告)日：2019-07-11

申请号：US16357687

申请日：2019-03-19

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Mark J. Hall ,  Steven J. Guillaudeu ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K47/38 ,  A61K9/10 ,  A61K31/4166 ,  A61K31/343 ,  A61K9/16 ,  C08L1/28 ,  A61K9/28 ,  A61K9/14

CPC classification number: A61K47/38 ,  A61K9/10 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2866 ,  A61K31/343 ,  A61K31/4166 ,  C08L1/284

Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa»s and optionally one or more adjuvants.

公开(公告)号：US20170028069A1

公开(公告)日：2017-02-02

申请号：US15292914

申请日：2016-10-13

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Mark J. Hall ,  Steven J. Guillaudeu ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K47/38 ,  A61K31/343 ,  A61K31/4166 ,  A61K9/10

CPC classification number: A61K47/38 ,  A61K9/10 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2866 ,  A61K31/343 ,  A61K31/4166 ,  C08L1/284

Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period.The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying.Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.

Abstract translation: 或者，可以通过共混和挤出至少一种活性成分，至少一种粘度高达2.33mPa·s的纤维素醚和任选的一种或多种佐剂来制备固体分散体。

公开(公告)号：US20150140091A1

公开(公告)日：2015-05-21

申请号：US14413241

申请日：2013-07-12

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Nicholas S. Grasman ,  Steven J. Guillaudeu ,  Mark J. Hall ,  Uma Shrestha ,  Maureen L. Rose ,  William W. Porter, III ,  Wesley J. Spaulding ,  Kevin P. O'donnell ,  True L. Rogers

IPC: A61K47/38 ,  A61K9/16 ,  A61K9/14 ,  A61K9/48

CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/4891 ,  A61K31/343 ,  A61K31/4166 ,  A61K31/58

Abstract: A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.

Abstract translation: 一种固体分散体，其包含至少一种具有1.0至2.7的DS和0.40至1.30的DS的羟烷基甲基纤维素中的至少一种活性成分，其中DS是甲氧基的取代度，MS是羟基烷氧基 组，可以通过挤出或喷雾干燥来生产。

公开(公告)号：US20150209436A1

公开(公告)日：2015-07-30

申请号：US14413080

申请日：2013-07-12

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Mark J. Hall ,  Steven J. Guillaudeu ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K47/38 ,  A61K31/343 ,  A61K31/4166 ,  A61K9/14

CPC classification number: A61K47/38 ,  A61K9/10 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2866 ,  A61K31/343 ,  A61K31/4166 ,  C08L1/284

Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.

Abstract translation: 包含有机液体稀释剂和至少一种具有高达2.33mPa·s的非离子纤维素醚的非离子纤维素醚的液体组合物，其在20℃下以2重量％的水溶液测量，在 延长时间 液体组合物可用于通过喷雾干燥制备包含至少一种纤维素醚中的至少一种活性成分的固体分散体。 或者，可以通过共混和挤出至少一种活性成分，至少一种粘度高达2.33mPa·s的纤维素醚和任选的一种或多种佐剂来制备固体分散体。

公开(公告)号：US11000594B2

公开(公告)日：2021-05-11

申请号：US16357687

申请日：2019-03-19

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Mark J. Hall ,  Steven J. Guillaudeu ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K9/10 ,  A61K47/38 ,  A61K9/16 ,  A61K9/28 ,  C08L1/28 ,  A61K9/14 ,  A61K31/343 ,  A61K31/4166

Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period. The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying. Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.

公开(公告)号：US10272156B2

公开(公告)日：2019-04-30

申请号：US15292914

申请日：2016-10-13

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Nicholas S. Grasman ,  Mark J. Hall ,  Steven J. Guillaudeu ,  Robert L. Schmitt ,  Matthias Knarr

IPC: A61K9/10 ,  A61K47/38 ,  A61K9/16 ,  A61K9/28 ,  C08L1/28 ,  A61K9/14 ,  A61K31/343 ,  A61K31/4166

Abstract: A liquid composition which comprises an organic liquid diluent and at least one non-ionic cellulose ether having a viscosity of up to 2.33 mPa·s, measured as a 2 wt.-% solution in water at 20° C., is stable over an extended time period.The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one cellulose ether by spray-drying.Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one cellulose ether having a viscosity of up to 2.33 mPa·s and optionally one or more adjuvants.

公开(公告)号：US09962446B2

公开(公告)日：2018-05-08

申请号：US14413241

申请日：2013-07-12

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Nicholas S. Grasman ,  Steven J. Guillaudeu ,  Mark J. Hall ,  Uma Shrestha ,  Maureen L. Rose ,  William W. Porter, III ,  Wesley J. Spaulding ,  Kevin P. O'donnell ,  True L. Rogers

IPC: A61K9/14 ,  A61K47/38 ,  A61K9/16 ,  A61K9/48 ,  A61K31/343 ,  A61K31/58 ,  A61K31/4166

CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/4891 ,  A61K31/343 ,  A61K31/4166 ,  A61K31/58

Abstract: A solid dispersion comprising at least one active ingredient in at least one hydroxyalkyl methylcellulose having a DS of from 1.0 to 2.7 and an MS of from 0.40 to 1.30, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxyalkoxyl groups, can be produced by extrusion or spray-drying.

公开(公告)号：US20140271833A1

公开(公告)日：2014-09-18

申请号：US14350535

申请日：2012-10-09

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Michael D. Read ,  Karen A. Coppens ,  Mark J. Hall ,  Jin Zhao

IPC: A61K9/48

CPC classification number: A61K9/4816 ,  A61K9/4833 ,  A61K9/4883 ,  C08K5/0016 ,  C08K5/05 ,  C08L1/28 ,  C08L1/286 ,  C08L5/00

Abstract: An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

Abstract translation: 具有良好质量的剂型的注射成型的外壳可以通过以下方式生产：a）提供组合物，其包含i）25至90重量％的乙基纤维素，ii）7.5至60重量％的不同于乙基纤维素的多糖或多糖衍生物 ，和iii）基于组合物的总重量，2.5至50重量％的至少一种与多糖和多糖衍生物不同的组分，条件是组合物包含零或不大于10重量％的明胶和 0或不超过10重量％的包含均聚或共聚的丙烯酸，均聚或共聚的甲基丙烯酸，均聚或共聚的丙烯酸酯或均聚或共聚的甲基丙烯酸酯的聚合物的聚合物，和b）使组合物经受剪切和加热 塑化组合物并将增塑组合物注塑成剂型的三维壳体。