公开(公告)号：US4886658A

公开(公告)日：1989-12-12

申请号：US284262

申请日：1988-12-14

申请人： Duane L. Charbonneau ,  Debra J. Moore ,  Joel I. Shulman

发明人： Duane L. Charbonneau ,  Debra J. Moore ,  Joel I. Shulman

IPC分类号： A61K8/00 ,  A61K8/18 ,  A61K8/38 ,  A61K8/40 ,  A61K8/43 ,  A61Q11/00

CPC分类号： A61Q11/00 ,  A61K8/38 ,  A61K8/43

摘要： The present invention relates to methods for treating or preventing dental plaque, caries, or gingival or periodontal diseases of the oral cavity in humans or lower animals, with reduced staining of teeth or dentures. The methods comprise topically applying to the oral surfaces of the teeth or dentures of the humans or lower animals:(a) a safe and effective amount of a monoperoxyphthalate compound, and(b) a safe and effective amount of an anti-plaque bis-biguanide compound.The present invention also relates to compositions for achieving such treatments.

公开(公告)号：US6108635A

公开(公告)日：2000-08-22

申请号：US858200

申请日：1997-04-30

申请人： L. Tandy Herren ,  Pamela K. Fink ,  Kenneth S. Kornman ,  Christopher J. Moehle ,  Debra J. Moore

发明人： L. Tandy Herren ,  Pamela K. Fink ,  Kenneth S. Kornman ,  Christopher J. Moehle ,  Debra J. Moore

IPC分类号： G06F19/00 ,  G06F17/60

CPC分类号： G06F19/363 ,  G06F19/322 ,  G06F19/3406 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24 ,  G06F19/324 ,  G06F19/328 ,  G06F19/3456

摘要： A system including a set of software based Explorers, and a computer assisted methodology support the development of new medical interventions for diseases. The system includes Explorer modules for discovering proposed interventions, designing clinical trials, performing pharmacoeconomic analysis, and illustrating disease progression for various patients over time including creating disease progression tutorials for patients. The Explorers support a bottom-up or data driven methodology that enables a user, such as medical researcher, to mine data sources of clinical, biologic, expert or other types of data to discover, test, evaluate, and understand a proposed intervention and its impact on disease progression in different patient types. A Target Discovery Explorer assists the user in identifying leverage points in disease progression in relationship to various patient attributes and interventions, thereby identifying a proposed intervention for the desease. A Clinical Trials Explorer assists the user in designing clinical trials based through identification of combinations of patient attributes and intervention attributes that yield efficacious changes in selected disease progression measures. A Pharmacoeconomic Explorer enables the user to determine relative costs-benefits of a proposed intervention for patients, practitioners, and payers, including quality of life results for patients, practice results for practitioners, and financial payment results for payers. A Disease Progression Explorer enables the user to visually project disease progression for specified patient attributes and interventions, in order to better understand and explain the effects of an intervention on a disease for such patients and their practitioners, and to select disease progression tutorials that are directed to the specific patient attributes and their corresponding effect on disease progression over time.

摘要翻译： 包括一套基于软件的探索者的系统和计算机辅助的方法支持开发新的疾病医疗干预措施。 该系统包括用于发现拟议干预措施的资源管理器模块，设计临床试验，进行药物经济学分析，并说明不同患者随时间的疾病进展，包括为病人制定疾病进展教程。 探索者支持自下而上或数据驱动的方法，使用户（如医学研究员）能够挖掘临床，生物学，专家或其他类型数据的数据来源，以发现，测试，评估和了解拟议的干预措施及其 对不同患者类型疾病进展的影响。 目标发现浏览器可帮助用户识别与各种患者属性和干预相关的疾病进展中的杠杆点，从而确定拟议的疾病干预。 临床试验探索者通过识别患者属性和干预属性的组合来帮助用户设计临床试验，从而在选定的疾病进展措施中产生有效的变化。 药物经济探索者使用户能够确定针对患者，从业者和付款人的拟议干预措施的相对成本效益，包括患者的生活质量结果，从业人员的实践结果以及付款人的财务支付结果。 疾病进展探查者使用户可以直观地预测特定患者属性和干预的疾病进展情况，以便更好地了解和解释干预对这种患者及其从业者的疾病的影响，并选择指导的疾病进展教程 具体患者属性及其对疾病进展的相应影响。