公开(公告)号：US5045565A

公开(公告)日：1991-09-03

申请号：US404924

申请日：1989-09-08

申请人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

发明人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

IPC分类号： C07C335/12

CPC分类号： C07C335/12

摘要： The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

摘要翻译： 本发明涉及β-氨基乙基取代的苯基化合物，特别是β-氨基乙氧基取代的苯基化合物。 本发明还涉及包含安全有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还涉及通过施用本发明的化合物或组合物在人类和低等动物中产生止痛和减轻炎症的方法。 此外，本发明涉及制备本发明化合物的方法和可用于这些合成方法的中间体。

公开(公告)号：US5099030A

公开(公告)日：1992-03-24

申请号：US722718

申请日：1991-06-27

申请人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

发明人： Joseph H. Gardner ,  Gerald B. Kasting ,  Thomas L. Cupps ,  Richard S. Echler ,  Thomas W. Gibson ,  Joel I. Shulman

IPC分类号： C07C335/12

CPC分类号： C07C335/12

摘要： The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

摘要翻译： 本发明涉及β-氨基乙基取代的苯基化合物，特别是β-氨基乙氧基取代的苯基化合物。 本发明还涉及包含安全有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还涉及通过施用本发明的化合物或组合物在人类和低等动物中产生止痛和减轻炎症的方法。 此外，本发明涉及制备本发明化合物的方法和可用于这些合成方法的中间体。

公开(公告)号：US4465810A

公开(公告)日：1984-08-14

申请号：US394076

申请日：1982-07-01

申请人： Dennis C. Toepker ,  Sheila S. Rodriguez ,  Joel I. Shulman

发明人： Dennis C. Toepker ,  Sheila S. Rodriguez ,  Joel I. Shulman

IPC分类号： C08F290/08 ,  C08F290/12 ,  C08F290/14 ,  C08F299/00 ,  C08F8/00

CPC分类号： C08F290/08 ,  C08F290/12 ,  C08F290/14 ,  C08F299/00

摘要： A class of polymer precursor materials, which, under appropriate conditions, react to form cross-linked polymers, is disclosed. These materials contain a backbone segment, preferably a polyacrylate, and have pendant therefrom (1) reactive mono- or disubstituted olefinic groups, such as vinyl or allyl itaconate, and (2) water-solubilizing groups, such as the half ester of maleic acid. This class of materials, especially when combined with specifically-defined oxygen-activated catalyst systems, provides water-based paint compositions which exhibit film formation, strength and durability characteristics comparable to those of the best solvent-based paint formulations.

摘要翻译： 公开了一类在适当条件下反应形成交联聚合物的聚合物前体材料。 这些材料包含主链段，优选聚丙烯酸酯，并且具有侧链（1）反应性单取代或双取代的烯基，例如衣康酸乙烯酯或烯丙基烯丙基酯，和（2）水溶性基团，例如马来酸的半酯 。 这类材料，特别是当与特定的氧活化催化剂体系结合使用时，提供了水性涂料组合物，其表现出与最佳溶剂型涂料配方相当的成膜性，强度和耐久性。

公开(公告)号：US4209468A

公开(公告)日：1980-06-24

申请号：US879655

申请日：1978-02-21

申请人： Joel I. Shulman

发明人： Joel I. Shulman

IPC分类号： A23L3/3463 ,  C07F9/50 ,  C08G65/335 ,  C09K15/32 ,  C11B5/00 ,  C07D105/02 ,  C07D107/02

CPC分类号： C07F9/5022 ,  A23L3/3463 ,  C07F9/5031 ,  C08G65/335 ,  C09K15/322 ,  C11B5/0071

摘要： Oligomeric or polymeric triaryl- and substituted triarylphosphine compounds which are non-digestible and non-absorbable by animals are disclosed. These compounds act as antioxidants by inhibiting the buildup of hydroperoxides of unsaturated fatty acids, e.g., in foods.

摘要翻译： 公开了不可消化和不可吸收动物的低聚或聚合三芳基和取代的三芳基膦化合物。 这些化合物通过抑制例如食品中不饱和脂肪酸的氢过氧化物的积累而起抗氧化剂的作用。

公开(公告)号：US4045469A

公开(公告)日：1977-08-30

申请号：US360864

申请日：1973-05-16

申请人： Wayne I. Fanta ,  Joel I. Shulman

发明人： Wayne I. Fanta ,  Joel I. Shulman

IPC分类号： C07C61/13 ,  C07C61/28 ,  C07C61/39 ,  C07C69/76 ,  C07C63/337 ,  C07C63/44

CPC分类号： C07C61/13 ,  C07C61/28 ,  C07C61/39 ,  C07C2103/18

摘要： Described are certain spiro carboxylic acids and their allethrolone esters. The esters of these acids possess unique insecticidal properties and are useful as such in home, garden and agricultural applications.

摘要翻译： 描述了某些螺羧酸及其降冰片酮。 这些酸的酯具有独特的杀虫性质，并且在家庭，花园和农业应用中是有用的。

公开(公告)号：US4886658A

公开(公告)日：1989-12-12

申请号：US284262

申请日：1988-12-14

申请人： Duane L. Charbonneau ,  Debra J. Moore ,  Joel I. Shulman

发明人： Duane L. Charbonneau ,  Debra J. Moore ,  Joel I. Shulman

IPC分类号： A61K8/00 ,  A61K8/18 ,  A61K8/38 ,  A61K8/40 ,  A61K8/43 ,  A61Q11/00

CPC分类号： A61Q11/00 ,  A61K8/38 ,  A61K8/43

摘要： The present invention relates to methods for treating or preventing dental plaque, caries, or gingival or periodontal diseases of the oral cavity in humans or lower animals, with reduced staining of teeth or dentures. The methods comprise topically applying to the oral surfaces of the teeth or dentures of the humans or lower animals:(a) a safe and effective amount of a monoperoxyphthalate compound, and(b) a safe and effective amount of an anti-plaque bis-biguanide compound.The present invention also relates to compositions for achieving such treatments.

公开(公告)号：US4164592A

公开(公告)日：1979-08-14

申请号：US805666

申请日：1977-06-13

申请人： Bryan L. Madison ,  Joel I. Shulman

发明人： Bryan L. Madison ,  Joel I. Shulman

IPC分类号： A23L5/10 ,  C11B5/00 ,  A23D5/04 ,  A23L3/34

CPC分类号： C11B5/0071 ,  A23L5/11

摘要： The disclosed process is a method for improving the flavor of fried foods, especially chicken, by frying said food in an oil or fat containing a compound which prevents the build-up of hydroperoxides of fatty acids and esters thereof and the decomposition products of the hydroperoxides in both the oil and the food.

摘要翻译： 所公开的方法是通过在含有防止脂肪酸及其酯的氢过氧化物的积聚物和氢过氧化物的分解产物的油或脂肪中煎炸所述食物来提高油炸食品，特别是鸡肉的风味的方法 在油和食物。