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公开(公告)号：US11512290B2
公开(公告)日：2022-11-29
申请号：US16982964
申请日：2019-03-21
Applicant: Duke University
Inventor： Conrad Hodgkinson , Victor Dzau , Jaewoo Lee , Bruce A. Sullenger
IPC: C07H21/02 , C12N5/077 , A61K31/713 , C12N15/113
Abstract: Disclosed herein are compositions and methods for cellular reprogramming. The compositions comprise one or more miRs and an activator of NFκB. Also provided are methods for enhancing or upregulating cardiomyocyte maturation in a cell or a subject and methods for inhibiting or downregulating cardiomyocyte maturation.
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