公开(公告)号：US20180117182A1

公开(公告)日：2018-05-03

申请号：US15570065

申请日：2016-04-28

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Kady-Ann C. Steen-Burrell ,  Bethany Powell Gray

IPC: A61K49/00 ,  C12N15/115

CPC classification number: A61K49/0002 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0054 ,  C07H21/02 ,  C12N15/115 ,  C12N2310/113 ,  C12N2310/16 ,  C12N2310/317 ,  C12N2310/3517 ,  C12N2310/322 ,  C12N2310/3533 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.

公开(公告)号：US20230330271A1

公开(公告)日：2023-10-19

申请号：US18086378

申请日：2022-12-21

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Kady-Ann C. Steen-Burrell ,  Bethany Powell Gray

IPC: A61K49/00 ,  C07H21/02 ,  C12N15/115

CPC classification number: A61K49/0002 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0054 ,  C07H21/02 ,  C12N15/115 ,  C12N2310/113 ,  C12N2310/16 ,  C12N2310/317 ,  C12N2310/3517

Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.

公开(公告)号：US11565002B2

公开(公告)日：2023-01-31

申请号：US16880791

申请日：2020-05-21

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Kady-Ann C. Steen-Burrell ,  Bethany Powell Gray

IPC: A61K49/00 ,  C12N15/115 ,  C07H21/02

Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.

公开(公告)号：US10660973B2

公开(公告)日：2020-05-26

申请号：US15570065

申请日：2016-04-28

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Kady-Ann C. Steen-Burrell ,  Bethany Powell Gray

IPC: A61K49/00 ,  C07H21/02 ,  C12N15/115

Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.