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公开(公告)号：US20130137752A1
公开(公告)日：2013-05-30
申请号：US13813465
申请日：2011-08-02
申请人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
发明人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
IPC分类号： C12N15/113
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/332 , C12N2310/346 , C12N2310/3521 , C12N2320/32
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression.
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2.发明授权RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) 有权使用短干扰核酸（siNA）的RNA干扰介导的连环素（钙粘蛋白相关蛋白），β1（CTNNB1）基因表达的抑制公开(公告)号：US08518907B2
公开(公告)日：2013-08-27
申请号：US13813465
申请日：2011-08-02
申请人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
发明人： Duncan Brown , James J. Cunningham , Marian Gindy , Victoria Pickering , Matthew G. Stanton , Steven M. Stirdivant , Walter R. Strapps
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/332 , C12N2310/346 , C12N2310/3521 , C12N2320/32
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对CTNNB1基因表达和/或活性的调节作用和/或调节β-连环蛋白基因表达途径的性状，疾病和病症的化合物，组合物和方法 。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对CTNNB1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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3.发明申请RNA Interference Mediated Inhibition of the Intercellular Adhesion Molecule 1 (ICAM-1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）的细胞间粘附分子1（ICAM-1）基因表达的抑制公开(公告)号：US20120004282A1
公开(公告)日：2012-01-05
申请号：US13256170
申请日：2010-03-25
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of ICAM-1 gene expression and/or activity, and/or modulate a ICAM-1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against ICAM-1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应于ICAM-1基因表达和/或活性的调节和/或调节ICAM-1基因的性状，疾病和病症的化合物，组合物和方法 表达途径。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对ICAM-1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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公开(公告)号：US08426581B2
公开(公告)日：2013-04-23
申请号：US13256095
申请日：2010-03-25
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2320/51 , C12N2310/3521 , C12N2310/3533 , C12N2310/3531
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCεR1α gene expression and/or activity, and/or modulate a FCεR1α gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCεR1α gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对FCepsilonR1α基因表达和/或活性的调节和/或调节FCepsilonR1apha基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短链的双链核酸分子 能够介导或介导针对FCepsilonR1apha基因表达的RNA干扰（RNAi）的发夹RNA（shRNA）分子。
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5.发明申请RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）的信号转导和转录激活因子1（STAT1）基因表达的抑制作用公开(公告)号：US20120022142A1
公开(公告)日：2012-01-26
申请号：US13256146
申请日：2010-03-25
IPC分类号： A61K31/713 , A61P11/14 , A61P11/06 , C07H21/02 , A61P11/00
CPC分类号： C12N15/113 , A61K31/712 , A61K31/713 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of STAT1 gene expression and/or activity, and/or modulate a STAT1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against STAT1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应STAT1基因表达和/或活性的调节和/或调节STAT1基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对STAT1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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6.发明申请RNA Interference Mediated Inhibition of Apoptosis Signal-Regulating Kinase 1 (ASK1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的细胞凋亡抑制信号调节激酶1（ASK1）基因表达使用短干扰核酸（siNA）公开(公告)号：US20120010272A1
公开(公告)日：2012-01-12
申请号：US13256089
申请日：2010-03-25
IPC分类号： A61K31/713 , A61P11/06 , A61P11/14 , C07H21/02 , A61P11/00
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2320/32 , C12N2320/51 , C12N2310/3521 , C12N2310/3533 , C12N2310/3531
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of ASK1 gene expression and/or activity, and/or modulate a ASK1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against ASK1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对ASK1基因表达和/或活性的调节作用和/或调节ASK1基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对ASK1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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7.发明申请RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）的神经生长因子β链（NGFB）基因表达的抑制公开(公告)号：US20120004281A1
公开(公告)日：2012-01-05
申请号：US13256105
申请日：2010-03-25
CPC分类号： C12N15/1136 , A61K31/712 , A61K31/713 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of NGFβ gene expression and/or activity, and/or modulate a NGFβ gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against NGFβ gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对NGF和bgr的调节作用的性状，疾病和病症的化合物，组合物和方法; 基因表达和/或活性，和/或调节NGF和bgr; 基因表达途径。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对NGF和bgr的RNA干扰（RNAi）的短发夹RNA（shRNA）分子; 基因表达。
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8.发明申请RNA Interference Mediated Inhibition of the High Affinity 1 gE Receptor Alpha Chain (FC Epsilon R1 Alpha) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权RNA干扰介导的使用短干扰核酸（siNA）的高亲和力1 gE受体α链（FC Epsilon R1 Alpha）基因表达的抑制作用公开(公告)号：US20120004280A1
公开(公告)日：2012-01-05
申请号：US13256095
申请日：2010-03-25
IPC分类号： A61K31/713 , C07H21/00 , A61P11/14 , A61P29/00 , A61P11/06 , A61P11/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2320/51 , C12N2310/3521 , C12N2310/3533 , C12N2310/3531
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCεR1α gene expression and/or or activity, and/or modulate a FCεR1α gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCεR1α gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应于FCα和R1α基因表达和/或/或活性的调节和/或调节FCα和Rαα的性状，疾病和病症的化合物，组合物和方法 基因表达途径。 具体地说，本发明涉及包括小核酸分子如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短链的双链核酸分子 能够介导或介导RNA干扰（RNAi）的发夹RNA（shRNA）分子与FCα和R1α基因表达的结合。
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9.发明申请RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的信号转导和抑制转录6（STAT6）基因表达使用短干扰核酸（siNA）公开(公告)号：US20120035247A1
公开(公告)日：2012-02-09
申请号：US13255744
申请日：2010-03-17
CPC分类号： A61K31/712 , A61K31/713 , C12N15/113 , C12N2310/14
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of STAT6 gene expression and/or activity, and/or modulate a STAT6 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsR-NA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against STAT6 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对STAT6基因表达和/或活性的调节和/或调节STAT6基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsR-NA），微RNA（miRNA）的双链核酸分子 ）和能够介导或介导针对STAT6基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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10.发明申请RNA Interference Mediated Inhibition of GATA Binding Protein 3 (GATA3) Gene Expression Using Short Intefering Nucleic Acid (siNA) 审中-公开RNA干扰介导的GATA结合蛋白3（GATA3）基因表达的抑制使用短核酸（siNA）公开(公告)号：US20120029054A1
公开(公告)日：2012-02-02
申请号：US13255725
申请日：2010-03-17
IPC分类号： A61K31/713 , A61P11/14 , A61P11/06 , C07H21/02 , A61P11/00
CPC分类号： C12N15/113 , A61K31/712 , A61K31/713 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of GATA3 gene expression and/or activity, and/or modulate a GATA3 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsR-NA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against GATA3 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对GATA3基因表达和/或活性的调节和/或调节GATA3基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsR-NA），微RNA（miRNA）的双链核酸分子 ）和能够介导或介导针对GATA3基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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