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公开(公告)号：US20100260685A1
公开(公告)日：2010-10-14
申请号：US12739977
申请日：2008-10-29
IPC分类号： A61K49/04 , C07C275/40 , C07D413/14
CPC分类号： A61K49/04 , A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R—Y—X—Z—R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式R-Y-X-Z-R化合物，其中每个R表示进一步被亲水部分取代的三碘化苯基残基，Y Z为脲和氨基甲酸酯基，X为可进一步取代的亚烷基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。
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公开(公告)号：US20100008864A1
公开(公告)日：2010-01-14
申请号：US12499281
申请日：2009-07-08
申请人： Andreas Meijer , Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
发明人： Andreas Meijer , Harry John Wadsworth , Ian Martin Newington , Clare L. Jones , Amanda Ewan , Dennis O'Shea , Oskar Axelsson , Anders Brathe , Andreas Olsson , John Henrik Johansen , Duncan George Wynn
CPC分类号： A61K49/124
摘要： The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
摘要翻译： 本发明涉及式（I）和（II）的新化合物，包含式（II）化合物的组合物及其作为磁共振（MR）成像（MRI）和MR光谱学（MRS）中的造影剂的用途。
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公开(公告)号：US08551449B2
公开(公告)日：2013-10-08
申请号：US12739977
申请日：2008-10-29
CPC分类号： A61K49/04 , A61K49/0438 , C07C237/46
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds of the formula R—Y—X—Z—R where each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties, Y and Z are urea and urethane groups and X is a alkylene group which may be further substituted. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这种化合物的诊断组合物，其中化合物是含碘的式RYXZR化合物，其中每个R表示进一步被亲水部分取代的三碘代苯基，Y和Z是脲和氨基甲酸酯基团， X是可以被进一步取代的亚烷基。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中，特别是在X射线成像中的用途，以及含有这些化合物的造影剂。
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公开(公告)号：US08158804B2
公开(公告)日：2012-04-17
申请号：US12521195
申请日：2008-01-11
IPC分类号： C07D213/89 , C07D213/69
CPC分类号： C07D213/81 , A61K49/103
摘要： The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
摘要翻译： 本发明涉及螯合剂，特别涉及能够与顺磁金属离子如铁（III）和钆（III）形成络合物的螯合剂。 本发明还涉及形成的复合物及其作为MRI造影剂的用途。
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5.发明申请CHELATORS, PARAMAGNETIC CHELATES THEREOF AND THEIR USE AS CONTRAST AGENTS IN MAGNETIC RESONANCE IMAGING (MRI) 审中-公开引证文献，参考文献及其作为磁共振成像（MRI）的对比剂使用公开(公告)号：US20110200536A1
公开(公告)日：2011-08-18
申请号：US12672117
申请日：2008-08-12
IPC分类号： A61K49/10 , C07D407/14 , C07D401/14 , C07D403/14 , C07K2/00 , C07K16/00 , A61P43/00 , C08F8/30 , C08F138/02 , B82Y5/00
CPC分类号： C07D213/69 , C07D309/40 , C07D401/14 , C07D405/14
摘要： The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).
摘要翻译： 本发明涉及螯合剂，特别涉及能够与顺磁金属离子形成络合物即顺磁性螯合物的螯合剂。 本发明还涉及所述顺磁性螯合物，所述顺磁性螯合物与其它分子连接，以及它们在磁共振成像（MRI）中作为造影剂的用途。
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公开(公告)号：US20100056787A1
公开(公告)日：2010-03-04
申请号：US12521195
申请日：2008-01-11
IPC分类号： C07D213/89 , C07D213/69
CPC分类号： C07D213/81 , A61K49/103
摘要： The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI contrast agents.
摘要翻译： 本发明涉及螯合剂，特别涉及能够与顺磁金属离子如铁（III）和钆（III）形成络合物的螯合剂。 本发明还涉及形成的复合物及其作为MRI造影剂的用途。
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7.发明授权Paramagnetic chelates thereof and their use as contrast agents in magnetic resonance imaging (MRI) 失效其磁性螯合物及其作为造影剂用于磁共振成像（MRI）公开(公告)号：US08475768B2
公开(公告)日：2013-07-02
申请号：US12672113
申请日：2008-08-12
IPC分类号： A61B5/055 , C08G18/62 , C07D213/62
CPC分类号： C07D401/14 , C07D213/81 , C07D309/40 , C07D407/14
摘要： The present invention relates to chelators, in particular to chelators which are capable of forming complexes, i.e. paramagnetic chelates, with paramagnetic metal ions. The invention also relates to said paramagnetic chelates, said paramagnetic chelates linked to other molecules and their use as contrast agents in magnetic resonance imaging (MRI).
摘要翻译： 本发明涉及螯合剂，特别涉及能够与顺磁金属离子形成络合物即顺磁性螯合物的螯合剂。 本发明还涉及所述顺磁性螯合物，所述顺磁性螯合物与其它分子连接，以及它们在磁共振成像（MRI）中作为造影剂的用途。
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公开(公告)号：US08066974B2
公开(公告)日：2011-11-29
申请号：US12299794
申请日：2007-05-10
IPC分类号： A61K49/04
CPC分类号： C07C275/42 , A61K49/0433 , C07C271/28
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有脲或氨基甲酸酯官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US20090136425A1
公开(公告)日：2009-05-28
申请号：US12299794
申请日：2007-05-10
IPC分类号： A61K49/00 , C07C275/24 , C07D413/14 , C07C271/02
CPC分类号： C07C275/42 , A61K49/0433 , C07C271/28
摘要： The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
摘要翻译： 本发明涉及一类化合物和含有这些化合物的诊断组合物，其中化合物是含碘化合物。 更具体地，含碘化合物是含有含有脲或氨基甲酸酯官能团的脂族中心部分的化合物，其允许与其结合的三个碘化苯基的排列。 本发明还涉及这种诊断组合物作为造影剂在诊断成像中的用途，特别是在X射线成像中以及含有这种化合物的造影剂的用途。
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公开(公告)号：US07935852B2
公开(公告)日：2011-05-03
申请号：US10559878
申请日：2005-04-06
CPC分类号： C07C277/08 , C07B59/001 , C07B2200/05 , C07B2200/11 , C07C17/361 , C07C51/363 , C07C227/16 , C07D209/88 , C07D213/75 , C07D221/20 , C07D231/12 , C07D239/553 , C07D239/95 , C07D401/12 , C07D487/04 , C07C229/36 , C07C279/06 , C07C25/13 , C07C63/70
摘要： A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent.
摘要翻译： 用氟离子源氟化碘鎓盐的方法，其可以在水性反应溶剂中进行。
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