-
1.发明授权Compositions and methods for treating NIDDM and other conditions and disorders associated with AMPK regulation 有权用于治疗NIDDM和其他与AMPK调节相关的病症和障碍的组合物和方法公开(公告)号：US07320806B2
公开(公告)日：2008-01-22
申请号：US10526837
申请日：2003-08-29
IPC分类号： A61K36/8998
CPC分类号： A61K36/00 , A61K36/8998
摘要： Compositions and methods are provided to increase glucose uptake in a cell as well as to treat a patient suffering from a condition or disorder associated with AMPK regulation. Particularly contemplated compositions include a compound that is isolated from a plant that has AICAR-like activity. In another aspect of the invention, contemplated compositions comprise a non-insulin compound that has AICAR-like activity and activates AMPK in a cell.
摘要翻译： 提供组合物和方法以增加细胞中的葡萄糖摄取以及治疗患有与AMPK调节相关的病症或障碍的患者。 特别考虑的组合物包括从具有AICAR样活性的植物中分离的化合物。 在本发明的另一方面，预期的组合物包含具有AICAR样活性并在细胞中活化AMPK的非胰岛素化合物。
-
公开(公告)号：US20090203638A1
公开(公告)日：2009-08-13
申请号：US12419950
申请日：2009-04-07
IPC分类号： A61K31/7076 , A61K31/52 , A61P3/00
CPC分类号： A61K31/52 , A61K31/513 , A61K31/522 , A61K31/7052 , A61K31/7076 , A61K45/06 , G01N33/74 , G01N2800/042 , G01N2800/044 , Y10S514/866 , A61K2300/00
摘要： Pharmaceutical compositions include compounds with cytokinin activity to modulate glucose and/or lipid metabolism in a mammal. Especially preferred compounds include those comprising a purine scaffold, and it is further preferred that contemplated compositions are employed to prevent and/or treat various diseases, including pre-diabetes, insulin resistance, type-2 diabetes, Syndrome X, and dyslipidemia. In still further preferred aspects, compounds with cytokinin activity are used to activate AMPK and/or Akt. Consequently, various diseases associated with dysregulation of AMPK and/or Akt may be treated using the compounds of the present inventive subject matter.
摘要翻译： 药物组合物包括具有细胞分裂素活性以调节哺乳动物中的葡萄糖和/或脂质代谢的化合物。 特别优选的化合物包括含有嘌呤支架的那些化合物，并且进一步优选的是，预期的组合物用于预防和/或治疗各种疾病，包括前期糖尿病，胰岛素抵抗，2型糖尿病，X综合征和血脂异常。 在另外的优选方面，使用具有细胞分裂素活性的化合物来活化AMPK和/或Akt。 因此，可以使用本发明主题的化合物治疗与AMPK和/或Akt失调相关的各种疾病。
-
公开(公告)号：US20090208620A1
公开(公告)日：2009-08-20
申请号：US12419553
申请日：2009-04-07
IPC分类号： G09F23/00
CPC分类号： A61K31/52 , A23L7/126 , A23L33/10 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2200/326 , A23V2200/332 , A23V2250/21
摘要： Contemplated food products include compounds with cytokinin activity to modulate glucose and/or lipid metabolism, and in especially preferred aspects contemplated food products include one or more naturally occurring cytokinins (e.g., kinetin, N2-acetylguanine, zeatin, dihydrozeatin) at a concentration effective to prevent or treat pre-diabetes, insulin resistance, type-2 diabetes, syndrome X, and/or dyslipidemia. Methods of marketing such products are also contemplated.
摘要翻译： 考虑的食品包括具有细胞分裂素活性以调节葡萄糖和/或脂质代谢的化合物，并且在特别优选的方面，所考虑的食品包括一种或多种天然存在的细胞分裂素（例如激动素，N 2 - 乙酰基鸟嘌呤，玉米素，二氢青霉素） 预防或治疗前期糖尿病，胰岛素抵抗，2型糖尿病，X综合征和/或血脂异常。 也考虑了销售这种产品的方法。
-
4.发明申请Compositions and methods for treating niddm and other conditions and disorders associated with ampk regulation 有权用于治疗与鼻涕调节相关的鼻窦和其他病症和障碍的组合物和方法公开(公告)号：US20060134240A1
公开(公告)日：2006-06-22
申请号：US10526837
申请日：2003-08-29
IPC分类号： A61K36/8998
CPC分类号： A61K36/00 , A61K36/8998
摘要： Compositions and methods are provided to increase glucose uptake in a cell as well as to treat a patient suffering from a condition or disorder associated with AMPK regulation. Particularly contemplated compositions include a compound that is isolated from a plant that has AICAR-like activity. In another aspect of the invention, contemplated compositions comprise a non-insulin compound that has AICAR-like activity and activates AMPK in a cell.
摘要翻译： 提供组合物和方法以增加细胞中的葡萄糖摄取以及治疗患有与AMPK调节相关的病症或障碍的患者。 特别考虑的组合物包括从具有AICAR样活性的植物中分离的化合物。 在本发明的另一方面，预期的组合物包含具有AICAR样活性并在细胞中活化AMPK的非胰岛素化合物。
-
公开(公告)号：US5723589A
公开(公告)日：1998-03-03
申请号：US576817
申请日：1995-12-21
IPC分类号： C07H15/04 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61K31/7064 , A61K31/7072 , A61P25/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07G3/00 , C07H1/00 , C07H9/04 , C07H19/056 , C07H19/06 , C07H21/04
CPC分类号： C07H9/04 , A61K47/48092 , C07H19/056 , C07H19/06
摘要： Methods and compositions are provided which increase the cellular uptake of bioactive materials by covalently bonding such compounds to carbohydrate moieties through chemical linkers using other than glycosidic bonds. Numerous carbohydrates, linkers and bioactive materials can be joined in this way to form novel compositions, which are collectively referred to herein as glinkosides. Preferred glinkosides are preferentially taken up by glucose receptor and/or other cellular receptors, and once inside the cells, the glinkosides are cleaved into a sugar, a linker or linker fragments, and a biologically active compound. Various aspects of the invention include processes for synthesizing glinkosides, glinkoside compositions, and methods of treating diseases using glinkosides.
摘要翻译： 提供了通过使用不同于糖苷键的化学连接体将这些化合物共价键合到碳水化合物部分来增加生物活性物质的细胞吸收的方法和组合物。 可以以这种方式连接许多碳水化合物，接头和生物活性材料以形成新的组合物，其在本文中统称为格洛糖苷。 优选的glinkosides优先被葡萄糖受体和/或其他细胞受体吸收，并且一旦在细胞内，将glinkosides切割成糖，接头或接头片段和生物活性化合物。 本发明的各个方面包括合成格洛糖苷，链霉素组合物的方法，以及使用格洛糖苷治疗疾病的方法。
-
公开(公告)号：US08642651B2
公开(公告)日：2014-02-04
申请号：US13175354
申请日：2011-07-01
IPC分类号： A61K39/385 , A61K31/28 , A01N43/00
CPC分类号： A61K31/555 , A61K9/1664 , A61K47/46
摘要： Complex metal-containing matrices, and especially chromium-containing matrices are produced from a water soluble preparation that is derived from an item suitable for animal (and most typically human) consumption. In particularly contemplated aspects, the water soluble preparation is an extract or filtrate of disintegrated brewer's yeast, and the so prepared complex mixture is combined with a chromium-3+ ions.
摘要翻译： 含有金属的复合基质，特别是含铬基质，由适用于动物（最典型地是人类）消费的物质的水溶性制剂产生。 在特别考虑的方面，水溶性制剂是分解的酿造酵母的提取物或滤液，将如此制备的复合混合物与铬-3 +离子结合。
-
公开(公告)号：US20110263702A1
公开(公告)日：2011-10-27
申请号：US13175354
申请日：2011-07-01
CPC分类号： A61K31/555 , A61K9/1664 , A61K47/46
摘要： Complex metal-containing matrices, and especially chromium-containing matrices are produced from a water soluble preparation that is derived from an item suitable for animal (and most typically human) consumption. In particularly contemplated aspects, the water soluble preparation is an extract or filtrate of disintegrated brewer's yeast, and the so prepared complex mixture is combined with a chromium-3+ ions.
摘要翻译： 含有金属的复合基质，特别是含铬基质，由适用于动物（最典型地是人类）消费的物质的水溶性制剂产生。 在特别考虑的方面，水溶性制剂是分解的酿造酵母的提取物或滤液，将如此制备的复合混合物与铬-3 +离子结合。
-
公开(公告)号：US08088752B2
公开(公告)日：2012-01-03
申请号：US12419950
申请日：2009-04-07
IPC分类号： A61K31/70
CPC分类号： A61K31/52 , A61K31/513 , A61K31/522 , A61K31/7052 , A61K31/7076 , A61K45/06 , G01N33/74 , G01N2800/042 , G01N2800/044 , Y10S514/866 , A61K2300/00
摘要： Pharmaceutical compositions include compounds with cytokinin activity to modulate glucose and/or lipid metabolism in a mammal. Especially preferred compounds include those comprising a purine scaffold, and it is further preferred that contemplated compositions are employed to prevent and/or treat various diseases, including pre-diabetes, insulin resistance, type-2 diabetes, Syndrome X, and dyslipidemia. In still further preferred aspects, compounds with cytokinin activity are used to activate AMPK and/or Akt. Consequently, various diseases associated with dysregulation of AMPK and/or Akt may be treated using the compounds of the present inventive subject matter.
摘要翻译： 药物组合物包括具有细胞分裂素活性以调节哺乳动物中的葡萄糖和/或脂质代谢的化合物。 特别优选的化合物包括含有嘌呤支架的那些化合物，并且进一步优选的是，预期的组合物用于预防和/或治疗各种疾病，包括前期糖尿病，胰岛素抵抗，2型糖尿病，X综合征和血脂异常。 在另外的优选方面，使用具有细胞分裂素活性的化合物来活化AMPK和/或Akt。 因此，可以使用本发明主题的化合物治疗与AMPK和/或Akt失调相关的各种疾病。
-
公开(公告)号：US20070184067A1
公开(公告)日：2007-08-09
申请号：US10567868
申请日：2004-08-03
IPC分类号： A23L1/29
CPC分类号： A61K31/52 , A23L7/126 , A23L33/10 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2200/326 , A23V2200/332 , A23V2250/21
摘要： Contemplated food products include compounds with cytokinin activity to modulate glucose and/or lipid metabolism, and in especially preferred aspects contemplated food products include one or more naturally occurring cytokinins (e.g., kinetin, N2-acetylguanine, zeatin, dihydrozeatin) at a concentration effective to prevent or treat pre-diabetes, insulin resistance, type-2 diabetes, syndrome X, and/or dyslipidemia. Methods of marketing such products are also contemplated.
摘要翻译： 考虑的食品包括具有细胞分裂素活性以调节葡萄糖和/或脂质代谢的化合物，并且在特别优选的方面，所考虑的食品包括一种或多种天然存在的细胞分裂素（例如激动素，N 2 - 乙酰基鸟嘌呤，玉米素，二氢青霉素） 预防或治疗前期糖尿病，胰岛素抵抗，2型糖尿病，X综合征和/或血脂异常。 也考虑了销售这种产品的方法。
-
公开(公告)号：US20060029642A1
公开(公告)日：2006-02-09
申请号：US11035109
申请日：2005-01-12
IPC分类号： A61K47/00 , A61K31/555
CPC分类号： A61K31/555 , A61K9/1664 , A61K47/46
摘要： Complex metal-containing matrices, and especially chromium-containing matrices are produced from a water soluble preparation that is derived from an item suitable for animal (and most typically human) consumption. In particularly contemplated aspects, the water soluble preparation is an extract or filtrate of disintegrated brewer's yeast, and the so prepared complex mixture is combined with a chromium-3+ ions.
摘要翻译： 含有金属的复合基质，特别是含铬基质，由适用于动物（最典型地是人类）消费的物质的水溶性制剂产生。 在特别考虑的方面，水溶性制剂是分解的啤酒酵母的提取物或滤液，将如此制备的复合混合物与铬-3H +离子结合。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.02 秒)
