公开(公告)号：US20240226000A9

公开(公告)日：2024-07-11

申请号：US18351192

申请日：2023-07-12

申请人： Dyve Biosciences, Inc.

发明人： Nathan FITZSIMMONS ,  Ryan BEAL ,  Charles A. HARBERT ,  Audrene RICE ,  Brandon SAND ,  Parshva KOTHARY ,  Bruce SAND

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K31/196 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/436 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61K31/575 ,  A61K31/65 ,  A61K31/7028 ,  A61K31/7052 ,  A61K31/7064 ,  A61K33/26 ,  A61K38/07 ,  A61K38/14 ,  A61K38/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K31/196 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/436 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61K31/575 ,  A61K31/65 ,  A61K31/7028 ,  A61K31/7052 ,  A61K31/7064 ,  A61K33/26 ,  A61K38/07 ,  A61K38/14 ,  A61K38/4893 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  C12Y304/24069

摘要： The present disclosure relates to a formulations and methods for transdermal delivery of a medicament through the skin of a subject. In aspects, the formulation comprises a therapeutically effective amount of a medicament and a penetrant portion in which the penetrant portion comprises: a phospholipid, a fatty acid ester formed from a low molecular weight alcohol, and a long-chain fatty acids. In some embodiments, the penetrant portion further comprises one or more of a viscosity-improving agent, a penetration enhancer, and an emulsifier.

公开(公告)号：US20220323344A1

公开(公告)日：2022-10-13

申请号：US17830236

申请日：2022-06-01

申请人： Dyve Biosciences, Inc.

发明人： Nathan FITZSIMMONS ,  Ryan BEAL ,  Brandon SAND

IPC分类号： A61K9/00 ,  A61K47/12

摘要： Embodiments include a transdermal delivery formulation and method for transdermal delivery of an active agent for systemic distribution. A formulation can be applied to skin, nail or hair follicle of a subject. After penetrating the stratum corneum, the agent can pass through other layers of skin as junctional proteins and/or acto-myosin belts between cells are modulated. The formulation can include one or more agents to treat a disease, ailment or an anesthetic to alleviate pain. Alternatively, it can include one or more nutrients, vitamins, minerals or supplements to promote health and well-being.

公开(公告)号：US20240130962A1

公开(公告)日：2024-04-25

申请号：US18351192

申请日：2023-07-11

申请人： Dyve Biosciences, Inc.

发明人： Nathan FITZSIMMONS ,  Ryan BEAL ,  Charles A. HARBERT ,  Audrene RICE ,  Brandon SAND ,  Parshva KOTHARY ,  Bruce SAND

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K31/196 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/436 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61K31/575 ,  A61K31/65 ,  A61K31/7028 ,  A61K31/7052 ,  A61K31/7064 ,  A61K33/26 ,  A61K38/07 ,  A61K38/14 ,  A61K38/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K31/196 ,  A61K31/4015 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/436 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61K31/575 ,  A61K31/65 ,  A61K31/7028 ,  A61K31/7052 ,  A61K31/7064 ,  A61K33/26 ,  A61K38/07 ,  A61K38/14 ,  A61K38/4893 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  C12Y304/24069

摘要： The present disclosure relates to a formulations and methods for transdermal delivery of a medicament through the skin of a subject. In aspects, the formulation comprises a therapeutically effective amount of a medicament and a penetrant portion in which the penetrant portion comprises: a phospholipid, a fatty acid ester formed from a low molecular weight alcohol, and a long-chain fatty acids. In some embodiments, the penetrant portion further comprises one or more of a viscosity-improving agent, a penetration enhancer, and an emulsifier.

公开(公告)号：US20220305076A1

公开(公告)日：2022-09-29

申请号：US17839323

申请日：2022-06-13

申请人： Dyve Biosciences, Inc.

发明人： Ryan BEAL ,  Nathan FITZSIMMONS ,  Audrene Rice ,  Brandon SAND ,  Kilmar MARTINEZ

IPC分类号： A61K38/13 ,  A61K9/00 ,  A61K47/44 ,  A61P17/06 ,  A61K31/59 ,  A61K31/122 ,  A61K31/07 ,  A61K45/06 ,  A61P19/02 ,  A61K9/06

摘要： Disclosed herein is a transdermal delivery formulation for transdermal delivery of cyclosporine with or without one or more additional active agents through the dermis, including the skin, nail or hair follicle of a subject. The formulation overcomes the limitations of oral administration. Specifically, embodiments include a formulation and method of delivering cyclosporine systemically into the skin to treat psoriasis or other ailments.

公开(公告)号：US20220105062A1

公开(公告)日：2022-04-07

申请号：US17554449

申请日：2021-12-17

申请人： Dyve Biosciences, Inc.

发明人： Nathan FITZSIMMONS ,  Ryan BEAL ,  Brandon SAND

IPC分类号： A61K31/195 ,  A61K9/00 ,  A61K47/24 ,  A61K47/26 ,  A61K47/12 ,  A61K47/10 ,  A61K31/045 ,  A61P35/00

摘要： Disclosed herein is a transdermal delivery formulation for transdermal delivery of an active agent through the skin, nail or hair follicle of a subject, wherein the formulation comprises a) a transdermal delivery formulation in an amount less than about 60% w/w, comprising i. one or more phosphatides, ii. glucose, and iii. one or more fatty acids; and b) water in an amount less than about 50% w/w.