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公开(公告)号：US20240226000A9
公开(公告)日：2024-07-11
申请号：US18351192
申请日：2023-07-12
发明人： Nathan FITZSIMMONS , Ryan BEAL , Charles A. HARBERT , Audrene RICE , Brandon SAND , Parshva KOTHARY , Bruce SAND
IPC分类号： A61K9/00 , A61K9/06 , A61K31/196 , A61K31/4015 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/4178 , A61K31/4196 , A61K31/436 , A61K31/44 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/546 , A61K31/573 , A61K31/575 , A61K31/65 , A61K31/7028 , A61K31/7052 , A61K31/7064 , A61K33/26 , A61K38/07 , A61K38/14 , A61K38/48 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24
CPC分类号： A61K9/0014 , A61K9/06 , A61K31/196 , A61K31/4015 , A61K31/4035 , A61K31/404 , A61K31/415 , A61K31/4178 , A61K31/4196 , A61K31/436 , A61K31/44 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/546 , A61K31/573 , A61K31/575 , A61K31/65 , A61K31/7028 , A61K31/7052 , A61K31/7064 , A61K33/26 , A61K38/07 , A61K38/14 , A61K38/4893 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , C12Y304/24069
摘要： The present disclosure relates to a formulations and methods for transdermal delivery of a medicament through the skin of a subject. In aspects, the formulation comprises a therapeutically effective amount of a medicament and a penetrant portion in which the penetrant portion comprises: a phospholipid, a fatty acid ester formed from a low molecular weight alcohol, and a long-chain fatty acids. In some embodiments, the penetrant portion further comprises one or more of a viscosity-improving agent, a penetration enhancer, and an emulsifier.
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公开(公告)号：US20240033284A1
公开(公告)日：2024-02-01
申请号：US18331875
申请日：2023-06-08
发明人： Ryan BEAL
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24
CPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/0014 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/3955 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/2818 , A61K9/7023 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/24 , C07K2317/76 , A61K2039/505
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US11793830B2
公开(公告)日：2023-10-24
申请号：US17497794
申请日：2021-10-08
发明人： Ryan Beal
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K39/00
CPC分类号： A61K33/00 , A61K9/0014 , A61K9/06 , A61K9/16 , A61K9/7023 , A61K31/045 , A61K31/133 , A61K31/198 , A61K31/4172 , A61K31/661 , A61K31/685 , A61K31/704 , A61K33/30 , A61K33/42 , A61K35/00 , A61K39/3955 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/24 , A61P35/04 , C07K16/2818 , A61K2039/505 , C07K2317/76 , A61K33/00 , A61K2300/00 , A61K33/30 , A61K2300/00 , A61K31/685 , A61K2300/00 , A61K31/045 , A61K2300/00 , A61K39/3955 , A61K2300/00
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US11357792B2
公开(公告)日：2022-06-14
申请号：US17488132
申请日：2021-09-28
发明人： Ryan Beal
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K39/00
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US20220016159A1
公开(公告)日：2022-01-20
申请号：US17488154
申请日：2021-09-28
发明人： Ryan BEAL
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US11744853B2
公开(公告)日：2023-09-05
申请号：US17514653
申请日：2021-10-29
发明人： Ryan Beal
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K39/00
CPC分类号： A61K33/00 , A61K9/0014 , A61K9/06 , A61K9/16 , A61K9/7023 , A61K31/045 , A61K31/133 , A61K31/198 , A61K31/4172 , A61K31/661 , A61K31/685 , A61K31/704 , A61K33/30 , A61K33/42 , A61K35/00 , A61K39/3955 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/24 , A61P35/04 , C07K16/2818 , A61K2039/505 , C07K2317/76 , A61K33/00 , A61K2300/00 , A61K33/30 , A61K2300/00 , A61K31/685 , A61K2300/00 , A61K31/045 , A61K2300/00 , A61K39/3955 , A61K2300/00
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US11730756B2
公开(公告)日：2023-08-22
申请号：US17168114
申请日：2021-02-04
发明人： Ryan Beal
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K39/00
CPC分类号： A61K33/00 , A61K9/0014 , A61K9/06 , A61K9/16 , A61K9/7023 , A61K31/045 , A61K31/133 , A61K31/198 , A61K31/4172 , A61K31/661 , A61K31/685 , A61K31/704 , A61K33/30 , A61K33/42 , A61K35/00 , A61K39/3955 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/22 , A61K47/24 , A61P35/04 , C07K16/2818 , A61K2039/505 , C07K2317/76 , A61K33/00 , A61K2300/00 , A61K33/30 , A61K2300/00 , A61K31/685 , A61K2300/00 , A61K31/045 , A61K2300/00 , A61K39/3955 , A61K2300/00
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US20220023336A1
公开(公告)日：2022-01-27
申请号：US17488132
申请日：2021-09-28
发明人： Ryan BEAL
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US20220016158A1
公开(公告)日：2022-01-20
申请号：US17488143
申请日：2021-09-28
发明人： Ryan BEAL
IPC分类号： A61K33/00 , A61K31/198 , A61K31/4172 , A61K31/133 , A61K9/00 , A61K35/00 , A61K9/16 , A61K33/42 , A61P35/04 , A61K31/704 , A61K39/395 , A61K31/661 , A61K9/06 , A61K31/045 , A61K31/685 , A61K33/30 , C07K16/28 , A61K9/70 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24
摘要： Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.
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公开(公告)号：US12070503B2
公开(公告)日：2024-08-27
申请号：US17934056
申请日：2022-09-21
发明人： Bruce J. Sand , Ryan R. Beal , Philippe H. Burnham
IPC分类号： A61K47/24 , A61F13/00 , A61F13/02 , A61K8/02 , A61K8/04 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/42 , A61K8/49 , A61K8/55 , A61K8/86 , A61K9/00 , A61K9/06 , A61K9/107 , A61K31/137 , A61K31/167 , A61K31/196 , A61K31/245 , A61K31/454 , A61K31/7004 , A61K33/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/28 , A61Q7/00 , A61Q19/08
CPC分类号： A61K47/24 , A61F13/00063 , A61F13/02 , A61K8/0291 , A61K8/042 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/42 , A61K8/4953 , A61K8/553 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K9/1075 , A61K31/137 , A61K31/167 , A61K31/196 , A61K31/245 , A61K31/454 , A61K31/7004 , A61K33/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/28 , A61Q7/00 , A61Q19/08
摘要： Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.
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