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1.发明申请Pharmaceutical formulations of fenofibrate having improved bioavailability 审中-公开具有改善的生物利用度的非诺贝特的药物制剂公开(公告)号：US20070148233A1
公开(公告)日：2007-06-28
申请号：US11321157
申请日：2005-12-28
IPC分类号： A61K9/20 , A61K9/14 , A61K31/192
CPC分类号： A61K9/0007 , A61K9/2013 , A61K9/2027 , A61K31/192
摘要： Provided are pharmaceutical compositions of fenofibrate, and dosage forms containing them, that include fenofibrate, a polyethylene glycol, and a polyethylene-polypropylene glycol; wherein the compositions are made by subliming a sublimable carrier from a combination of fenofibrate, the polyethylene glycol, and the polyethylene-polypropylene glycol with the sublimable carrier, for example menthol.
摘要翻译： 提供非诺贝特的药物组合物和含有它们的剂型，包括非诺贝特，聚乙二醇和聚乙二醇聚丙二醇; 其中通过将非诺贝特，聚乙二醇和聚乙烯 - 聚丙二醇与升华载体如薄荷醇的组合升华可升华载体来制备组合物。
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公开(公告)号：US20060222707A1
公开(公告)日：2006-10-05
申请号：US11353504
申请日：2006-02-13
IPC分类号： A61K9/20 , A61K31/192
CPC分类号： A61K9/4858 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K31/192 , A61K31/216
摘要： The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of a fibrate drug, preferably fenofibrate, intimately associated with a surfactant mixture, preferably a mixture comprising PGE 6000 and poloxamer 407. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject the composition.
摘要翻译： 本发明提供至少一种用于治疗升高水平的甘油三酸酯的组合物，其包含治疗有效量的与表面活性剂混合物，优选包含PGE 6000和泊洛沙姆407的混合物紧密相关的贝特类药物，优选非诺贝特。本发明还提供 用于治疗受试者中甘油三酸酯水平升高的方法，包括向受试者施用组合物。
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公开(公告)号：US20060141052A1
公开(公告)日：2006-06-29
申请号：US11357757
申请日：2006-02-17
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, drug delivery vehicles comprising same, and methods for making them.
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公开(公告)号：US20060141051A1
公开(公告)日：2006-06-29
申请号：US11357248
申请日：2006-02-17
IPC分类号： A61K31/519 , A61K9/14
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, drug delivery vehicles comprising same, and methods for making them.
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5.发明授权Drug microparticles, processes of preparing them and a drug delivery vehicle comprising them 有权药物微粒，其制备方法和包含它们的药物递送载体公开(公告)号：US08663703B2
公开(公告)日：2014-03-04
申请号：US12635417
申请日：2009-12-10
IPC分类号： A61K9/14
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, which are prepared by removing a sublimable carrier from a solid solution of the a active pharmaceutical ingredients in the sublimable carrier. Also provided are drug delivery vehicles comprising a carrier particle bearing the microparticles on its surface.
摘要翻译： 提供了活性药物成分的微粒，其通过从活化药物成分在可升华载体中的固溶体除去可升华载体而制备。 还提供了药物递送载体，其包含在其表面上带有微粒的载体颗粒。
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公开(公告)号：US20100092568A1
公开(公告)日：2010-04-15
申请号：US12635417
申请日：2009-12-10
IPC分类号： A61K9/14 , B05D3/00 , A61K31/4985 , A61K31/55 , A61K31/7048 , A61P35/00
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, drug delivery vehicles comprising same, and methods for making them.
摘要翻译： 提供了活性药物成分的微粒，包含其的药物递送载体及其制备方法。
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公开(公告)号：US20060141050A1
公开(公告)日：2006-06-29
申请号：US11356682
申请日：2006-02-17
IPC分类号： A61K31/557 , A61K9/14
CPC分类号： A61K9/1682 , A61K9/167 , A61K9/1676 , A61K9/1694 , A61K31/519 , B01J13/02 , B01J13/125
摘要： Provided are microparticles of active pharmaceutical ingredients, drug delivery vehicles comprising same, and methods for making them.
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公开(公告)号：US20070015833A1
公开(公告)日：2007-01-18
申请号：US11182777
申请日：2005-07-18
IPC分类号： A61K31/192
CPC分类号： A61K9/4866 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/2018 , A61K9/2031 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/44
摘要： The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of fenofibrate or another fibrate drug intimately associated with menthol, optionally in the presence of at least one surfactant mixture. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject a composition comprising a therapeutically effective amount of fenofibrate or another fibrate drug and menthol, wherein the fenofibrate or the other fibrate drug is in intimate association with the menthol, wherein the menthol can be menthol or menthol surfactant mixture.
摘要翻译： 本发明提供至少一种用于治疗升高水平的甘油三酸酯的组合物，其包含治疗有效量的非诺贝特或与薄荷醇密切相关的另一种贝特类药物，任选地在至少一种表面活性剂混合物的存在下。 本发明还提供了一种治疗受试者中甘油三酸酯水平升高的方法，其包括对受试者施用包含治疗有效量的非诺贝特或另一种贝特类药物和薄荷醇的组合物，其中非诺贝特或其他贝特类药物是亲密的 与薄荷醇的缔合，其中薄荷醇可以是薄荷醇或薄荷醇表面活性剂混合物。
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公开(公告)号：US20070015834A1
公开(公告)日：2007-01-18
申请号：US11182778
申请日：2005-07-18
IPC分类号： A61K31/192
CPC分类号： A61K9/4866 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/2018 , A61K9/2031 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/44
摘要： The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of fenofibrate or another fibrate drug intimately associated with a polyethylene glycol and a poloxamer, preferably PEG 1000 and Poloxamer 407. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject the fenofibrate composition of the invention.
摘要翻译： 本发明提供至少一种用于治疗升高水平的甘油三酸酯的组合物，其包含治疗有效量的非诺贝特或与聚乙二醇和泊洛沙姆（优选PEG 1000和泊洛沙姆407）密切相关的另一种贝特类药物。本发明还提供了一种方法 用于治疗受试者中升高的甘油三酸酯水平，包括向受试者施用本发明的非诺贝特组合物。
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公开(公告)号：US20060141028A1
公开(公告)日：2006-06-29
申请号：US11202603
申请日：2005-08-12
IPC分类号： A61K38/13 , A61K31/366 , A61K31/225 , A61K31/045 , A61K9/20
CPC分类号： A61K9/145 , A61K9/146 , A61K9/4858 , A61K9/4866 , A61K31/045 , A61K31/225 , A61K31/366 , A61K31/4535 , A61K38/13 , A61K47/10
摘要： The present invention relates to compositions comprising solutions of drugs in menthol, especially drugs that are poorly soluble in water, and to methods for making such compositions.
摘要翻译： 本发明涉及包含药物在薄荷醇中的溶液的组合物，特别是难溶于水的药物以及制备这些组合物的方法。
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