公开(公告)号：US20190292162A1

公开(公告)日：2019-09-26

申请号：US16302564

申请日：2017-05-17

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin LI ,  Yufang XU ,  Rui WANG ,  Zhenjiang ZHAO ,  Wenlin SONG ,  Liuxin XU

IPC分类号： C07D277/50 ,  A61P19/02

摘要： A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

公开(公告)号：US20190134008A1

公开(公告)日：2019-05-09

申请号：US16306465

申请日：2017-06-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  INSTITUT OF PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES

发明人： Ke XU ,  Honglin LI ,  Yufang XU ,  Zhenjiang ZHAO ,  Lili ZHU ,  Wenlin SONG ,  Yi TONG

IPC分类号： A61K31/426 ,  A61P31/12

摘要： Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection: