公开(公告)号：US20190134008A1

公开(公告)日：2019-05-09

申请号：US16306465

申请日：2017-06-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  INSTITUT OF PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES

发明人： Ke XU ,  Honglin LI ,  Yufang XU ,  Zhenjiang ZHAO ,  Lili ZHU ,  Wenlin SONG ,  Yi TONG

IPC分类号： A61K31/426 ,  A61P31/12

摘要： Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:

公开(公告)号：US20230190713A1

公开(公告)日：2023-06-22

申请号：US17905629

申请日：2021-03-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  WUHAN UNIVERSITY

发明人： Honglin LI ,  Ke XU ,  Shiliang LI ,  Lili ZHU ,  Zhenjiang ZHAO

IPC分类号： A61K31/426 ,  A61P31/14 ,  A61P31/16 ,  A61K31/513 ,  A61K31/427 ,  A61K31/7056 ,  A61K31/675 ,  A61K31/215 ,  A61K31/351 ,  A61K31/19 ,  A61K31/4706

CPC分类号： A61K31/426 ,  A61K31/19 ,  A61K31/215 ,  A61K31/351 ,  A61K31/427 ,  A61K31/513 ,  A61K31/675 ,  A61K31/4706 ,  A61K31/7056 ,  A61P31/14 ,  A61P31/16

摘要： An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.

公开(公告)号：US20200163983A1

公开(公告)日：2020-05-28

申请号：US16630309

申请日：2018-07-12

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  YUNNAN UNIVERSITY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Honglin LI ,  Weilie XIAO ,  Lili ZHU ,  Lina QUAN ,  Qiao LI ,  Yanyan DIAO ,  Zhenjiang ZHAO ,  Hualiang JIANG

IPC分类号： A61K31/704 ,  A61P35/00 ,  A61K31/56

摘要： Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.

公开(公告)号：US20210179598A1

公开(公告)日：2021-06-17

申请号：US17046996

申请日：2019-04-12

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin LI ,  Yufang XU ,  Zhenjiang ZHAO ,  Lili ZHU

IPC分类号： C07D413/10 ,  C07D401/14 ,  C07D405/14 ,  C07D213/73 ,  C07D401/04 ,  C07D401/10 ,  C07D487/04 ,  C07D471/04 ,  C07D401/12 ,  C07D417/04

摘要： Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation of the medicament for treating JAK2-mediated related diseases.