公开(公告)号：US20190292162A1

公开(公告)日：2019-09-26

申请号：US16302564

申请日：2017-05-17

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin LI ,  Yufang XU ,  Rui WANG ,  Zhenjiang ZHAO ,  Wenlin SONG ,  Liuxin XU

IPC: C07D277/50 ,  A61P19/02

Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

公开(公告)号：US20220098134A1

公开(公告)日：2022-03-31

申请号：US17424105

申请日：2020-06-12

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin LI ,  Zhenjiang ZHAO ,  Rui WANG ,  Yinchu SHEN ,  Jianjun FU ,  Yufang XU ,  Xuhong QIAN ,  Qian JIAO ,  Shiliang LI

IPC: C07C33/26 ,  C07C43/23 ,  C07C49/82 ,  C07C33/30 ,  C07C69/16 ,  A61P9/12

Abstract: The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

公开(公告)号：US20190290620A1

公开(公告)日：2019-09-26

申请号：US16302574

申请日：2017-05-17

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin LI ,  Zhenjiang ZHAO ,  Rui WANG ,  Yufang XU ,  Wanqi WANG ,  Yingfang YANG

IPC: A61K31/426 ,  A61P1/04

Abstract: The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis. The present invention specifically relates to applications of a compound represented by formula I and a pharmaceutical composition containing the compound represented by formula I, in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis: