公开(公告)号：US20230133910A1

公开(公告)日：2023-05-04

申请号：US17907055

申请日：2021-03-29

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Yi YANG ,  Xianjun CHEN ,  Xin XIE ,  Ni SU

IPC分类号： C12Q1/6876 ,  C12Q1/6816

摘要： The present disclosure relates to an aptamer nucleic acid molecule, a complex containing the aptamer and fluorophore small molecules, a method for detecting intrecellular or extracellular RNA, DNA or other target molecules, as well as a kit containing the aptamer. The aptamer of the present disclosure can specifically bind to fluorophore small molecules, and can significantly improve their fluorescence intensity under light excitation at suitable wavelength.

公开(公告)号：US20230002769A1

公开(公告)日：2023-01-05

申请号：US17607102

申请日：2020-04-28

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Yi YANG ,  Linyong ZHU ,  Xianjun CHEN ,  Dasheng ZHANG ,  Ni SU ,  Qiuning LIN

IPC分类号： C12N15/115 ,  C07C255/58 ,  C12Q1/6876 ,  C12N15/10 ,  C07C255/53 ,  C07D241/20 ,  C07D213/74 ,  C07D239/42 ,  C07D213/85 ,  C07D241/24 ,  C07D263/56 ,  C07D277/64 ,  C07D333/60 ,  C07D495/04 ,  C09K11/06

摘要： The present application relates to an aptamer nucleic acid molecule, a complex containing the aptamer nucleic acid molecules, a method of detecting intracellular or extracellular RNA, DNA or other target molecules, and a kit containing the aptamer. The aptamer of the present application is capable of specifically binding a kind of fluorophore micromolecules, and can significantly enhance fluorescence intensity under excitation light of appropriate wavelength.