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公开(公告)号：US20180335647A1
公开(公告)日：2018-11-22
申请号：US15571276
申请日：2016-05-04
摘要： The invention relates to a contact lens for use in the treatment of ocular inflammatory pathologies. The contact lens comprises a soft porous material coupled, in certain embodiments, with detoxifying agents. Said material and/or agents contact and neutralize inflammatory mediators present in the tear fluid of ocular pathologies patients. The nature and architecture of the soft porous material allows a greater contact area between the material itself and/or detoxifying agents with inflammatory mediators, in view of the reversible compression of the soft material that allows greater lachrymal fluid turnover and fluid exchange within the contact lens upon e.g. blinking.
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公开(公告)号：US10816823B2
公开(公告)日：2020-10-27
申请号：US15571276
申请日：2016-05-04
摘要： The invention relates to a contact lens for use in the treatment of ocular inflammatory pathologies. The contact lens comprises a soft porous material coupled, in certain embodiments, with detoxifying agents. Said material and/or agents contact and neutralize inflammatory mediators present in the tear fluid of ocular pathologies patients. The nature and architecture of the soft porous material allows a greater contact area between the material itself and/or detoxifying agents with inflammatory mediators, in view of the reversible compression of the soft material that allows greater lachrymal fluid turnover and fluid exchange within the contact lens upon e.g. blinking.
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公开(公告)号：US11724006B2
公开(公告)日：2023-08-15
申请号：US16476564
申请日：2018-01-10
IPC分类号： A61L27/52 , B33Y10/00 , B33Y70/00 , B33Y80/00 , B29C64/112 , B29C64/245 , A61L27/56 , B29C64/00 , B29C35/16 , C12M1/00 , C12M1/12 , B29K105/00 , B29L31/00
CPC分类号： A61L27/52 , A61L27/56 , B29C35/16 , B29C64/00 , B29C64/112 , B29C64/245 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C12M1/12 , C12M23/34 , C12M25/14 , A61L2400/06 , B29K2105/0002 , B29K2105/0061 , B29L2031/7532
摘要： A method of producing a cryogel-based multicompartment 3D scaffold is herein disclosed. The method comprises the steps of: a) providing a first frozen polymeric layer on a refrigerated support kept at subzero temperature; b) providing subsequent polymeric layers to obtain a stack of polymeric layers by possibly modulating the subzero temperature of the refrigerated support; c) optionally incubating the final polymeric structure at subzero temperature; and d) placing the produced cryogel at a temperature above 0° C., the method being characterized in that each subsequent layer i) is deposited on the previous one after freezing of this latter; ii) is deposited on the previous one before the complete polymerization of this latter; and iii) is deposited with a temperature higher than the freezing temperature of the previously deposited layer. Cryogel scaffolds obtained from the method of the invention are also disclosed.
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