公开(公告)号：US20210010086A1

公开(公告)日：2021-01-14

申请号：US16881193

申请日：2020-05-22

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： Peggy A. Thompson ,  Wenqiong Joan Chen ,  James Appleman

IPC: C12Q1/6886 ,  A61K31/506 ,  G01N33/574

Abstract: The present disclosure relates to compositions and methods for identifying or diagnosing a human subject having or suspected of having a hyperproliferative disease and who would benefit from treatment with a MNK inhibitor.

公开(公告)号：US20190136321A1

公开(公告)日：2019-05-09

申请号：US16160820

申请日：2018-10-15

Applicant: The Regents of The University of California ,  eFFECTOR Therapeutics, Inc.

Inventor： Davide Ruggero ,  Andrew Hsieh ,  Merritt Edlind ,  Kevan M. Shokat ,  James Appleman ,  Steve Worland

IPC: C12Q1/6883 ,  C12Q1/6874 ,  G01N33/50

Abstract: The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein.

公开(公告)号：US10576098B2

公开(公告)日：2020-03-03

申请号：US15973281

申请日：2018-05-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James Appleman ,  Peggy A. Thompson

IPC: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.

公开(公告)号：US09993494B2

公开(公告)日：2018-06-12

申请号：US14616690

申请日：2015-02-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James Appleman ,  Peggy A. Thompson

IPC: A61K45/06 ,  A61K31/713 ,  C12Q1/68 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706

CPC classification number: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.

公开(公告)号：US20170247692A1

公开(公告)日：2017-08-31

申请号：US15114277

申请日：2015-02-06

Applicant: EFFECTOR THERAPEUTICS, INC.

Inventor： James Appleman ,  Peggy A. Thompson ,  Vera Huang

IPC: C12N15/113 ,  G01N33/50

CPC classification number: C12N15/113 ,  C07K14/705 ,  C12N2310/14 ,  G01N33/5023 ,  G01N33/5058

Abstract: The present disclosure relates to compositions and methods for treating or preventing a neurological disorder.

公开(公告)号：US20170191136A1

公开(公告)日：2017-07-06

申请号：US15389822

申请日：2016-12-23

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： Peggy A. Thompson ,  Wenqiong Joan Chen ,  James Appleman

IPC: C12Q1/68 ,  A61K31/506 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  A61K31/506 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  C12Q2600/112 ,  C12Q2600/118

Abstract: The present disclosure relates to compositions and methods for identifying or diagnosing a human subject having or suspected of having a hyperproliferative disease and who would benefit from treatment with a MNK inhibitor.

公开(公告)号：US20150224132A1

公开(公告)日：2015-08-13

申请号：US14616690

申请日：2015-02-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James Appleman ,  Peggy A. Thompson

IPC: A61K31/713 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/4245 ,  A61K45/06 ,  A61K31/436 ,  A61K31/16 ,  A61K31/155 ,  A61K31/706 ,  A61K31/357 ,  A61K31/519

CPC classification number: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.

Abstract translation: 本公开涉及用于治疗或预防纤维化病症或疾病的组合物和方法。