公开(公告)号：US20210010086A1

公开(公告)日：2021-01-14

申请号：US16881193

申请日：2020-05-22

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： Peggy A. Thompson ,  Wenqiong Joan Chen ,  James Appleman

IPC: C12Q1/6886 ,  A61K31/506 ,  G01N33/574

Abstract: The present disclosure relates to compositions and methods for identifying or diagnosing a human subject having or suspected of having a hyperproliferative disease and who would benefit from treatment with a MNK inhibitor.

公开(公告)号：US11576933B2

公开(公告)日：2023-02-14

申请号：US16616087

申请日：2018-05-24

Applicant: EFFECTOR THERAPEUTICS, INC.

Inventor： Peggy A. Thompson ,  Kevin R. Webster

IPC: A61K35/17 ,  A61P35/00 ,  A61K31/343 ,  A61K31/4355 ,  A61K45/06 ,  C07D471/12

Abstract: The present disclosure provides compositions and methods for improving an antitumor response against non-inflamed solid tumors. Methods of this disclosure include use of an eIF4A inhibitor to promote infiltration of antitumor lymphocytes into a non inflamed solid tumor. Methods of treating cancer associated with a non-inflamed solid tumor are also provided.

公开(公告)号：US20210299111A1

公开(公告)日：2021-09-30

申请号：US17210062

申请日：2021-03-23

Applicant: eFFECTOR Therapeutics Inc.

Inventor： Peggy A. Thompson ,  Kevin R. Webster

IPC: A61K31/4355 ,  A61K9/00 ,  A61K45/06 ,  A61P35/04

Abstract: The present disclosure relates to methods for ameliorating or treating an eIF4A dependent condition or disease in a subject in need thereof. The methods of the disclosure comprise administering to the subject a therapeutically effective amount of at least one eukaryotic translation initiation factor 4A (eIF4A) inhibitor and a therapeutically effective amount of at least one cyclin-dependent kinase (CDK) inhibitor.

公开(公告)号：US10576098B2

公开(公告)日：2020-03-03

申请号：US15973281

申请日：2018-05-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James Appleman ,  Peggy A. Thompson

IPC: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.

公开(公告)号：US09993494B2

公开(公告)日：2018-06-12

申请号：US14616690

申请日：2015-02-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James Appleman ,  Peggy A. Thompson

IPC: A61K45/06 ,  A61K31/713 ,  C12Q1/68 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706

CPC classification number: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.

公开(公告)号：US20170247692A1

公开(公告)日：2017-08-31

申请号：US15114277

申请日：2015-02-06

Applicant: EFFECTOR THERAPEUTICS, INC.

Inventor： James Appleman ,  Peggy A. Thompson ,  Vera Huang

IPC: C12N15/113 ,  G01N33/50

CPC classification number: C12N15/113 ,  C07K14/705 ,  C12N2310/14 ,  G01N33/5023 ,  G01N33/5058

Abstract: The present disclosure relates to compositions and methods for treating or preventing a neurological disorder.

公开(公告)号：US20170191136A1

公开(公告)日：2017-07-06

申请号：US15389822

申请日：2016-12-23

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： Peggy A. Thompson ,  Wenqiong Joan Chen ,  James Appleman

IPC: C12Q1/68 ,  A61K31/506 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  A61K31/506 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  C12Q2600/112 ,  C12Q2600/118

Abstract: The present disclosure relates to compositions and methods for identifying or diagnosing a human subject having or suspected of having a hyperproliferative disease and who would benefit from treatment with a MNK inhibitor.

公开(公告)号：US20150224132A1

公开(公告)日：2015-08-13

申请号：US14616690

申请日：2015-02-07

Applicant: eFFECTOR Therapeutics, Inc.

Inventor： James Appleman ,  Peggy A. Thompson

IPC: A61K31/713 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/4245 ,  A61K45/06 ,  A61K31/436 ,  A61K31/16 ,  A61K31/155 ,  A61K31/706 ,  A61K31/357 ,  A61K31/519

CPC classification number: A61K31/713 ,  A61K31/155 ,  A61K31/16 ,  A61K31/357 ,  A61K31/4245 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/496 ,  A61K31/519 ,  A61K31/706 ,  A61K45/06

Abstract: The present disclosure relates to compositions and methods for treating or preventing a fibrotic disorder or disease.

Abstract translation: 本公开涉及用于治疗或预防纤维化病症或疾病的组合物和方法。