公开(公告)号：US20230301990A1

公开(公告)日：2023-09-28

申请号：US18180063

申请日：2023-03-07

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Andrew COOK ,  Dominic REYNOLDS ,  Cheng ZHONG ,  Ryan BRAWN ,  Shelby ELLERY ,  Thiwanka SAMARAKOON ,  Xiang LIU ,  Sudeep PRAJAPATI ,  Megan SHEEHAN ,  Jason T. LOWE ,  James PALACINO

IPC: A61K31/496 ,  A61P35/00 ,  A61K9/00 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/551 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K39/395 ,  C07D313/00 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D453/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D498/08

CPC classification number: A61K31/496 ,  A61P35/00 ,  A61K9/0053 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/551 ,  A61K38/191 ,  A61K38/2013 ,  A61K38/2066 ,  A61K38/208 ,  A61K38/2086 ,  A61K38/217 ,  A61K39/3955 ,  C07D313/00 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D453/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D498/08 ,  C07B2200/05

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

公开(公告)号：US20210163456A1

公开(公告)日：2021-06-03

申请号：US17045952

申请日：2019-04-08

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Gregg F. KEANEY ,  John WANG ,  Baudouin GERARD ,  Kenzo ARAI ,  Xiang LIU ,  Guo Zhu ZHENG ,  Kazunobu KIRA ,  Lisa A. MARCAURELLE ,  Marta NEVALAINEN ,  Ming-Hong HAO ,  Morgan Welzel O'SHEA ,  Parcharee TIVITMAHAISOON ,  Sudeep PRAJAPATI ,  Touping LUO ,  Nicholas C. GEARHART ,  Jason T. LOWE ,  Yoshihiko KOTAKE ,  Satoshi NAGAO ,  Regina Mikie KANADA SONOBE ,  Masayuki MIYANO ,  Norio MURAI ,  Andrew COOK ,  Shelby ELLERY ,  Atsushi ENDO ,  James PALACINO ,  Dominic REYNOLDS

IPC: C07D407/06 ,  C07D405/14 ,  A61P35/00 ,  C07D313/00 ,  C07D491/107 ,  C07D487/08 ,  C07D487/10 ,  A61K45/06 ,  C07D405/12 ,  C07D417/12 ,  C07D413/12

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

公开(公告)号：US20210177837A1

公开(公告)日：2021-06-17

申请号：US17046528

申请日：2019-04-11

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Andrew COOK ,  Dominic REYNOLDS ,  Cheng ZHONG ,  Ryan BRAWN ,  Shelby ELLERY ,  Thiwanka SAMARAKOON ,  Xiang LIU ,  Sudeep PRAJAPATI ,  Megan SHEEHAN ,  Jason T. LOWE ,  James PALACINO

IPC: A61K31/496 ,  A61K9/00 ,  A61K39/395 ,  A61K38/21 ,  A61K38/20 ,  A61K38/19 ,  C07D313/00 ,  C07D405/06 ,  C07D405/10 ,  C07D405/12 ,  C07D413/14 ,  C07D498/08 ,  C07D491/107 ,  C07D407/12 ,  C07D417/10 ,  C07D413/10 ,  C07D487/04 ,  C07D453/02 ,  C07D405/14 ,  C07D413/12 ,  C07D409/12 ,  C07D471/10 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/541 ,  A61K31/506 ,  A61K31/551 ,  A61K31/5386 ,  A61P35/00

Abstract: The present disclosure provides pladienolide compounds, pharmaceutical compositions containing such compounds, and pladienolide compounds for use in methods of medical treatment. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are pladienolide compounds for use in methods of treating cancers by administering at least one pladienolide compound disclosed herein and at least one additional therapy.

公开(公告)号：US20240368140A1

公开(公告)日：2024-11-07

申请号：US18582548

申请日：2024-02-20

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Gregg F. KEANEY ,  John WANG ,  Baudouin GERARD ,  Kenzo ARAI ,  Xiang LIU ,  Guo Zhu ZHENG ,  Kazunobu KIRA ,  Lisa A. MARCAURELLE ,  Marta NEVALAINEN ,  Ming-Hong HAO ,  Morgan Welzel O'SHEA ,  Parcharee TIVITMAHAISOON ,  Sudeep PRAJAPATI ,  Tuoping LUO ,  Nicholas C. GEARHART ,  Jason T. LOWE ,  Yoshihiko KOTAKE ,  Satoshi NAGAO ,  Regina Mikie KANADA SONOBE ,  Masayuki MIYANO ,  Norio MURAI ,  Andrew COOK ,  Shelby ELLERY ,  Atsushi ENDO ,  James PALACINO ,  Dominic REYNOLDS

IPC: C07D407/06 ,  A61K45/06 ,  A61P35/00 ,  C07D313/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.