公开(公告)号：US20240148895A1

公开(公告)日：2024-05-09

申请号：US18237663

申请日：2023-08-24

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Masayuki MIYANO ,  Yuya NAKAZAWA ,  Kentaro ISO ,  Yuki YABE ,  Hirotatsu UMIHARA ,  Junichi TAGUCHI ,  Satoshi INOUE ,  Shuntaro TSUKAMOTO ,  Hiroyuki KOGAI ,  Atsumi YAMAGUCHI ,  Tsuyoshi AKAGI ,  Yohei MUKAI ,  Toshifumi HIRAYAMA ,  Masaki KATO ,  Toshiki MOCHIZUKI ,  Akihiko YAMAMOTO ,  Yuji YAMAMOTO ,  Takato SAKURADA

IPC: A61K47/68

CPC classification number: A61K47/6889 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6853 ,  A61K47/6855

Abstract: An antibody-drug conjugate represented by formula (I):






(where
Ab is an antibody,
X is a group represented by formula (X-1), formula (X-2) or formula (X-3):










(where

at the left represents the binding site with NH and

at the right represents the binding side with D),
D is a group represented by formula (D-1) or formula (D-2):










(where

represents the binding site with X), and
n is in the range of about 1 to about 8).

公开(公告)号：US20240368140A1

公开(公告)日：2024-11-07

申请号：US18582548

申请日：2024-02-20

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Gregg F. KEANEY ,  John WANG ,  Baudouin GERARD ,  Kenzo ARAI ,  Xiang LIU ,  Guo Zhu ZHENG ,  Kazunobu KIRA ,  Lisa A. MARCAURELLE ,  Marta NEVALAINEN ,  Ming-Hong HAO ,  Morgan Welzel O'SHEA ,  Parcharee TIVITMAHAISOON ,  Sudeep PRAJAPATI ,  Tuoping LUO ,  Nicholas C. GEARHART ,  Jason T. LOWE ,  Yoshihiko KOTAKE ,  Satoshi NAGAO ,  Regina Mikie KANADA SONOBE ,  Masayuki MIYANO ,  Norio MURAI ,  Andrew COOK ,  Shelby ELLERY ,  Atsushi ENDO ,  James PALACINO ,  Dominic REYNOLDS

IPC: C07D407/06 ,  A61K45/06 ,  A61P35/00 ,  C07D313/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

公开(公告)号：US20210163456A1

公开(公告)日：2021-06-03

申请号：US17045952

申请日：2019-04-08

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Gregg F. KEANEY ,  John WANG ,  Baudouin GERARD ,  Kenzo ARAI ,  Xiang LIU ,  Guo Zhu ZHENG ,  Kazunobu KIRA ,  Lisa A. MARCAURELLE ,  Marta NEVALAINEN ,  Ming-Hong HAO ,  Morgan Welzel O'SHEA ,  Parcharee TIVITMAHAISOON ,  Sudeep PRAJAPATI ,  Touping LUO ,  Nicholas C. GEARHART ,  Jason T. LOWE ,  Yoshihiko KOTAKE ,  Satoshi NAGAO ,  Regina Mikie KANADA SONOBE ,  Masayuki MIYANO ,  Norio MURAI ,  Andrew COOK ,  Shelby ELLERY ,  Atsushi ENDO ,  James PALACINO ,  Dominic REYNOLDS

IPC: C07D407/06 ,  C07D405/14 ,  A61P35/00 ,  C07D313/00 ,  C07D491/107 ,  C07D487/08 ,  C07D487/10 ,  A61K45/06 ,  C07D405/12 ,  C07D417/12 ,  C07D413/12

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.