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公开(公告)号：US20210139981A1
公开(公告)日：2021-05-13
申请号：US17156452
申请日：2021-01-22
发明人： Sinan ARSLAN , Chunhong ZHOU , Molly Min HE , Matthew KELLINGER , Adeline Huizhen MAH , Michael PREVITE , Lei SUN
IPC分类号： C12Q1/6876 , G01N33/543 , C12N9/12 , G01N21/64
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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公开(公告)号：US20210040534A1
公开(公告)日：2021-02-11
申请号：US17070796
申请日：2020-10-14
发明人： Chunhong ZHOU , Sinan ARSLAN , Molly Min HE , Matthew KELLINGER , Adeline Huizhen MAH , Michael PREVITE , Lei SUN
IPC分类号： C12Q1/682 , C12Q1/6869 , C12Q1/6867
摘要： Methods and formulations for preparing low non-specific binding surfaces are described, and the prepared surface can provide improved performance for nucleic acid detection and base calling applications. The surface provides more accurate nucleic acid detection, enhanced contrast to noise ratio, and better data collection.
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公开(公告)号：US20200248258A1
公开(公告)日：2020-08-06
申请号：US16855877
申请日：2020-04-22
发明人： Sinan ARSLAN , Chunhong ZHOU , Molly Min HE , Matthew KELLINGER , Adeline Huizhen MAH , Michael PREVITE , Lei SUN
IPC分类号： C12Q1/6876 , G01N33/543 , C12N9/12 , G01N21/64
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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公开(公告)号：US20230323450A1
公开(公告)日：2023-10-12
申请号：US18181476
申请日：2023-03-09
发明人： Sinan Arslan , Molly Min HE , Matthew KELLINGER , Jake LEVIEUX , Michael PREVITE , Junhua ZHAO , Su ZHANG , Tyler LOPEZ
IPC分类号： C12Q1/6874 , G01N33/58 , G01N33/53
CPC分类号： C12Q1/6874 , G01N33/582 , G01N33/5308
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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公开(公告)号：US20220186310A1
公开(公告)日：2022-06-16
申请号：US17511046
申请日：2021-10-26
发明人： Sinan Arslan , Molly Min HE , Matthew KELLINGER , Jake LEVIEUX , Michael PREVITE , Junhua ZHAO , Su ZHANG , Tyler LOPEZ
IPC分类号： C12Q1/6874 , G01N33/53 , G01N33/58
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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公开(公告)号：US20200182866A1
公开(公告)日：2020-06-11
申请号：US16739007
申请日：2020-01-09
发明人： Sinan ARSLAN , Chunhong ZHOU , Molly Min HE , Matthew KELLINGER , Adeline Huizhen MAH , Michael PREVITE , Lei SUN
IPC分类号： G01N33/543 , C12Q1/6844 , G01N21/64
摘要： Improved system and method are described that utilize surfaces with low non-specific binding supports and formulations for performing solid-phase nucleic acid hybridization and amplification. The system and method described herein provide improved performance for nucleic acid detection and other applications.
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公开(公告)号：US20210318295A1
公开(公告)日：2021-10-14
申请号：US17358507
申请日：2021-06-25
发明人： Sinan Arslan , Molly Min HE , Matthew KELLINGER , Jake LEVIEUX , Michael PREVITE , Junhua ZHAO , Su ZHANG
IPC分类号： G01N33/53 , G01N33/58 , C12Q1/6874
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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公开(公告)号：US20210318294A1
公开(公告)日：2021-10-14
申请号：US17356929
申请日：2021-06-24
发明人： Michael PREVITE , Molly Min HE , Junhua ZHAO , Hui Zhen MAH , Chunhong ZHOU , Sinan ARSLAN , Matthew KELLINGER , Lorenzo BERTI , Steve Xiangling CHEN
IPC分类号： G01N33/53 , G01N33/58 , C12Q1/6874
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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公开(公告)号：US20200263230A1
公开(公告)日：2020-08-20
申请号：US16740355
申请日：2020-01-10
发明人： Chunhong ZHOU , Sinan ARSLAN , Molly Min HE , Matthew KELLINGER , Adeline Huizhen MAH , Michael PREVITE , Lei SUN
IPC分类号： C12Q1/682 , C12Q1/6867 , C12Q1/6869
摘要： Methods and formulations for preparing low non-specific binding surfaces are described, and the prepared surface can provide improved performance for nucleic acid detection and base calling applications. The surface provides more accurate nucleic acid detection, enhanced contrast to noise ratio, and better data collection.
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公开(公告)号：US20200216899A1
公开(公告)日：2020-07-09
申请号：US16740357
申请日：2020-01-10
发明人： Sinan ARSLAN , Chunhong ZHOU , Molly Min HE , Matthew KELLINGER , Adeline Huizhen MAH , Michael PREVITE , Lei SUN
IPC分类号： C12Q1/6876 , G01N33/543 , C12N9/12 , G01N21/64
摘要： Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.
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