公开(公告)号：US10704094B1

公开(公告)日：2020-07-07

申请号：US16740357

申请日：2020-01-10

Applicant: ELEMENT BIOSCIENCES, INC.

Inventor： Sinan Arslan ,  Chunhong Zhou ,  Molly Min He ,  Matthew Kellinger ,  Adeline Huizhen Mah ,  Michael Previte ,  Lei Sun

IPC: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6876 ,  G01N33/543 ,  G01N21/64 ,  C12N9/12

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

公开(公告)号：US20200149095A1

公开(公告)日：2020-05-14

申请号：US16363842

申请日：2019-03-25

Applicant: Element Biosciences, Inc.

Inventor： Sinan Arslan ,  Chunhong Zhou ,  Molly Min He ,  Matthew Kellinger ,  Adeline Huizhen Mah ,  Michael Previte ,  Lei Sun

IPC: C12Q1/6834 ,  C12Q1/6874 ,  C12Q1/6832

Abstract: Low non-specific binding supports and formulations for performing solid-phase nucleic acid hybridization and amplification are described that provide improved performance for nucleic acid detection, amplification, and sequencing applications. These supports exhibit a high Contrast-to Noise Ratio (CNR), facilitating more accurate data collection and more accurate sequence reads.

公开(公告)号：US11287422B2

公开(公告)日：2022-03-29

申请号：US17356929

申请日：2021-06-24

Applicant: Element Biosciences, Inc.

Inventor： Michael Previte ,  Molly Min He ,  Junhua Zhao ,  Hui Zhen Mah ,  Chunhong Zhou ,  Sinan Arslan ,  Matthew Kellinger ,  Lorenzo Berti ,  Steve Xiangling Chen

IPC: G01N33/53 ,  G01N33/58 ,  C12Q1/68 ,  C12Q1/6874

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

公开(公告)号：US10982280B2

公开(公告)日：2021-04-20

申请号：US16855877

申请日：2020-04-22

Applicant: ELEMENT BIOSCIENCES, INC.

Inventor： Sinan Arslan ,  Chunhong Zhou ,  Molly Min He ,  Matthew Kellinger ,  Adeline Huizhen Mah ,  Michael Previte ,  Lei Sun

IPC: C12Q1/68 ,  C07H21/00 ,  C12Q1/6876 ,  G01N33/543 ,  C12N9/12 ,  G01N21/64

Abstract: Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.