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公开(公告)号：US20240217979A1
公开(公告)日：2024-07-04
申请号：US18287844
申请日：2022-04-21
申请人： Emory University
IPC分类号： C07D487/04 , A61K31/415 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4709 , A61K31/5025 , A61K31/519 , C07D231/06 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4709 , A61K31/5025 , A61K31/519 , C07D231/06 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds that selectively inhibit the GluN2 subunits of NMDA receptors are disclosed. In general, the compounds have superior activity against GluN2C/D subunit(s) over GluN2A/B subunit(s). Optionally, the compounds have a structure of Formulas (I), (II), (III), or other formulas disclosed herein, enantiomers or diastereomers thereof, or pharmaceutically acceptable salts thereof. Pharmaceutical formulations containing one or more of the compounds are also disclosed. Additionally, methods of treating a neurological condition or disorder using the compounds or their pharmaceutical formulations thereof are disclosed. Exemplary neurological conditions or disorders include Parkinson's disease, dystonia and related motor disorders, depression, neuropsychiatric indications, stoke, hypoxia, traumatic brain injury, acute injuries involving the white matter, Alzheimer's disease, compulsivity and related disorders, and epilepsy.
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公开(公告)号：US20230112832A1
公开(公告)日：2023-04-13
申请号：US17973336
申请日：2022-10-25
申请人： Emory University
发明人： Dennis C. Liotta , Edgars Jecs , Robert James Wilson , Huy Hoang Nguyen , Michelle Bora Kim , Lawrence Wilson , Eric Miller , Yesim Altas Tahirovic , Valarie Truax , Thomas Kaiser
IPC分类号： A61K31/4725 , A61P35/00 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/5377 , A61K31/541 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
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公开(公告)号：US20220296626A1
公开(公告)日：2022-09-22
申请号：US17512014
申请日：2021-10-27
申请人： Emory University
IPC分类号： A61K31/7068 , C07H19/06 , A61K45/06 , A61K9/127 , C07H19/10
摘要： This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
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公开(公告)号：US20220235092A1
公开(公告)日：2022-07-28
申请号：US17592870
申请日：2022-02-04
申请人： EMORY UNIVERSITY
发明人： David B. Guthrie , Mark A. Lockwood , Dennis C. Liotta , Michael G. Natchus , Donald G. Stein , Iqbal Sayeed
摘要： This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation resulting from traumatic brain injury or stroke.
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公开(公告)号：US20210395294A1
公开(公告)日：2021-12-23
申请号：US17360614
申请日：2021-06-28
申请人： EMORY UNIVERSITY
发明人： David Brian Guthrie , Mark Andrew Lockwood , Michael G. Natchus , Dennis C. Liotta , Donald G. Stein , Iqbal Sayeed
摘要： This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.
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公开(公告)号：US11117882B2
公开(公告)日：2021-09-14
申请号：US16053265
申请日：2018-08-02
申请人： Emory University
IPC分类号： C07D401/14 , C07D401/04 , A61K45/06 , A61K31/497 , A61K31/4709
摘要： This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful in therapeutic methods related thereto. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a compound of the following formula: or salts, esters, or prodrugs thereof, as provided herein.
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公开(公告)号：US20180094018A1
公开(公告)日：2018-04-05
申请号：US15728459
申请日：2017-10-09
申请人： Emory University
发明人： David Brian Guthrie , Mark Andrew Lockwood , Michael G. Natchus , Dennis C. Liotta , Donald G. Stein , Iqbal Sayeed
CPC分类号： C07J41/0016 , A61K31/57 , A61K31/58 , A61K31/661 , A61K45/06 , C07J41/005 , C07J43/003 , C07J51/00 , Y02A50/401 , A61K2300/00
摘要： This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.
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公开(公告)号：US09802978B2
公开(公告)日：2017-10-31
申请号：US14911807
申请日：2014-08-11
申请人： Emory University
发明人： David Brian Guthrie , Mark Andrew Lockwood , Michael G. Natchus , Dennis C. Liotta , Donald G. Stein , Iqbal Sayeed
CPC分类号： C07J41/0016 , A61K31/57 , A61K31/58 , A61K31/661 , A61K45/06 , C07J41/005 , C07J43/003 , C07J51/00 , Y02A50/401 , A61K2300/00
摘要： This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke.
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公开(公告)号：US20240360163A1
公开(公告)日：2024-10-31
申请号：US18756360
申请日：2024-06-27
申请人： Emory University
IPC分类号： C07F9/6512 , C07F9/6561
CPC分类号： C07F9/65128 , C07F9/6512 , C07F9/65616
摘要： Disclosed are acyclic nucleoside prodrugs with improved metabolic stability and oral bioavailability. In general, the prodrugs are derivatives of acyclic nucleoside phosphonates containing a lipid-like moiety that can increase oral absorption and subsequent stability in the liver and plasma. Preferably, the lipid-like moiety can resist enzyme-mediated ω-oxidation, such as ω-oxidation catalyzed by cytochrome P450 enzymes. Also disclosed are pharmaceutical formulations of the acyclic nucleoside prodrugs. The acyclic nucleoside prodrugs and pharmaceutical formulations thereof can be used to treat viral infections, such as HIV infections, and/or viral-associated cancer, such as HPV-associated cancers.
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公开(公告)号：US20240316034A1
公开(公告)日：2024-09-26
申请号：US18655194
申请日：2024-05-03
申请人： Emory University
发明人： Dennis C. Liotta , Edgars Jecs , Robert James Wilson , Huy Hoang Nguyen , Michelle Bora Kim , Lawrence Wilson , Eric Miller , Yesim Altas Tahirovic , Valarie Truax
IPC分类号： A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/5377 , A61K31/541 , A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
CPC分类号： A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/5377 , A61K31/541 , A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08
摘要： The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
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