公开(公告)号：US11912695B2

公开(公告)日：2024-02-27

申请号：US17574718

申请日：2022-01-13

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Kaicheng Zhu ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Adam Szymaniak ,  Jianming Yu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D413/14 ,  A61K31/5513 ,  A61P31/14 ,  C07D417/14 ,  A61K45/06

CPC classification number: C07D413/14 ,  A61P31/14 ,  C07D417/14 ,  A61K31/5513 ,  A61K45/06 ,  A61K31/5513 ,  A61K2300/00

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20220356189A1

公开(公告)日：2022-11-10

申请号：US16930622

申请日：2020-07-16

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam Szymaniak ,  Kevin McGrath ,  Jianming Yu ,  Tyler Mann ,  Long Nguyen ,  Kaicheng Zhu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D491/052 ,  C07D471/04

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20240360117A1

公开(公告)日：2024-10-31

申请号：US18420855

申请日：2024-01-24

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Kaicheng Zhu ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Adam Szymaniak ,  Jianming Yu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D413/14 ,  A61K31/5513 ,  A61K45/06 ,  A61P31/14 ,  C07D417/14

CPC classification number: C07D413/14 ,  A61P31/14 ,  C07D417/14 ,  A61K31/5513 ,  A61K45/06

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20230357258A1

公开(公告)日：2023-11-09

申请号：US18131405

申请日：2023-04-06

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Adam Szymaniak ,  Robert Leon ,  Kevin McGrath ,  Xiben Li ,  Tyler J. Mann ,  Jianming Yu ,  In Jong Kim ,  Scott Mitchell ,  Yat Sun Or

IPC: C07D491/048 ,  A61P31/14 ,  A61K45/06 ,  C07D519/00

CPC classification number: C07D491/048 ,  A61P31/14 ,  A61K45/06 ,  C07D519/00 ,  C07B2200/05

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20230125803A1

公开(公告)日：2023-04-27

申请号：US17894412

申请日：2022-08-24

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam Szymaniak ,  Kevin McGrath ,  Jianming Yu ,  Tyler Mann ,  Long Nguyen ,  Kaicheng Zhu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D491/052 ,  C07D471/04 ,  C07D491/044 ,  C07D491/048

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20220227746A1

公开(公告)日：2022-07-21

申请号：US17574718

申请日：2022-01-13

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Kaicheng Zhu ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Adam Szymaniak ,  Jianming Yu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D413/14 ,  A61P31/14 ,  C07D417/14

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US11945830B2

公开(公告)日：2024-04-02

申请号：US17679746

申请日：2022-02-24

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam Szymaniak ,  Jianming Yu ,  Kevin McGrath ,  Xiben Li ,  Tyler J. Mann ,  Robert Leon ,  In Jong Kim ,  Yat Sun Or ,  Long Nguyen

IPC: C07F9/09 ,  A61K31/14 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61K31/519 ,  A61K45/06 ,  C07D491/048 ,  C07D519/00

CPC classification number: C07F9/09 ,  A61K45/06 ,  C07D491/048 ,  C07D519/00

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:




which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20220119398A1

公开(公告)日：2022-04-21

申请号：US17503626

申请日：2021-10-18

Applicant: ENANTA PHARMACEUTICALS, INC.

Inventor： Yat Sun Or ,  Yong He ,  Kevin McGrath ,  Ruichao Shen ,  Adam Szymaniak ,  Xuechao Xing ,  In Jong Kim ,  Guoqiang Wang

IPC: C07D491/048 ,  A61P31/14 ,  A61K45/06

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV or HMPV infection. The invention also relates to methods of treating an RSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US20190002479A1

公开(公告)日：2019-01-03

申请号：US16023422

申请日：2018-06-29

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： In Jong Kim ,  Jianming yu ,  Joseph Panarese ,  Kevin McGrath ,  Solymar Negretti-Emmanuelli ,  Thomas P. Blaisdell ,  Brian C. Shook ,  Yat Sun Or

IPC: C07D519/00 ,  A61P31/16

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

公开(公告)号：US11572367B2

公开(公告)日：2023-02-07

申请号：US16930622

申请日：2020-07-16

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Adam Szymaniak ,  Kevin McGrath ,  Jianming Yu ,  Tyler Mann ,  Long Nguyen ,  Kaicheng Zhu ,  In Jong Kim ,  Yat Sun Or

IPC: C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D471/04

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.