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    DIAGNOSIS AND TREATMENT OF VIRAL DISEASES
    2.
    发明申请
    DIAGNOSIS AND TREATMENT OF VIRAL DISEASES 有权

    公开(公告)号：US20170168053A1

    公开(公告)日：2017-06-15

    申请号：US15439495

    申请日：2017-02-22

    申请人： ENZO BIOCHEM, INC

    发明人： Gerard Nuovo ,  Virginia Nivar

    IPC分类号： G01N33/569 ,  C12Q1/70 ,  C12Q1/68

    CPC分类号： G01N33/56994 ,  C07K16/085 ,  C07K16/244 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2710/16021 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/705 ,  C12Q2600/158 ,  G01N2333/03 ,  G01N2800/7052

    摘要： This disclosure relates to methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. The disclosure further relates to methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient. In addition, the disclosure relates to methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. The disclosure further relates to methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as to methods of preventing viral infection, including Herpesvirus saimiri infection.

    DIAGNOSIS AND TREATMENT OF VIRAL DISEASES
    6.
    发明申请
    DIAGNOSIS AND TREATMENT OF VIRAL DISEASES 有权
    诊断和治疗病毒

    公开(公告)号：US20150344976A1

    公开(公告)日：2015-12-03

    申请号：US14759687

    申请日：2014-01-08

    申请人： Gerard NUOVO ,  Virginia NIVAR ,  ENZO BIOCHEM, INC.

    发明人： Gerard Nuovo ,  Virginia Nivar

    IPC分类号： C12Q1/70 ,  C07K16/08 ,  G01N33/569

    CPC分类号： G01N33/56994 ,  C07K16/085 ,  C07K16/244 ,  C07K2317/33 ,  C07K2317/76 ,  C12N2710/16021 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q1/705 ,  C12Q2600/158 ,  G01N2333/03 ,  G01N2800/7052

    摘要： This disclosure relates to methods of diagnosing a viral disease such as idiopathic pulmonary fibrosis, Castleman's disease, a lymphoma, a thymoma or a sarcoma in a patient by identifying one or more virus-specific elements such as a nucleic acid or a viral protein or a patient antibody to a virus-specific element, as well as to kits for diagnosing the viral disease in a patient. The disclosure further relates to methods of monitoring disease progression and/or the efficacy of therapy by measuring the levels of a virus-specific element in a sample from a patient, in addition, the disclosure relates to methods of identifying therapeutic agents that show efficacy in reducing levels of virus-specific agents in vitro. The disclosure further relates to methods of treating idiopathic pulmonary fibrosis, a lymphoproliferative disease and cancer, as well as to methods of preventing viral infection, including Herpesvirus saimiri infection.

    摘要翻译： 本公开涉及通过鉴定一种或多种病毒特异性元件如核酸或病毒蛋白或病毒蛋白质来诊断患者中病毒性疾病如特发性肺纤维化，卡斯尔曼氏病，淋巴瘤，胸腺瘤或肉瘤的方法， 患者对病毒特异性元件的抗体，以及用于诊断患者病毒性疾病的试剂盒。 本公开还涉及通过测量来自患者的样品中病毒特异性元件的水平来监测疾病进展和/或治疗功效的方法，此外，本公开涉及鉴定治疗剂的方法，其在 在体外降低病毒特异性药物的水平。 本发明进一步涉及治疗特发性肺纤维化，淋巴组织增生性疾病和癌症的方法，以及预防病毒感染的方法，包括疱疹病毒西米尔感染。