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公开(公告)号：US20240360318A1
公开(公告)日：2024-10-31
申请号：US18422568
申请日：2024-01-25
申请人： Enzo Biochem, Inc.
发明人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda , Dee Shen
IPC分类号： C09B23/14 , C07D401/12 , C09B23/01 , C09B23/04 , C09B23/06 , C09B23/10 , G01N33/58 , G01N33/68
CPC分类号： C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
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公开(公告)号：US11745184B1
公开(公告)日：2023-09-05
申请号：US17352424
申请日：2021-06-21
申请人： Enzo Biochem, Inc.
发明人： Elazar Rabbani
CPC分类号： B01L3/5085 , C12M23/12 , B01L2300/0829 , B01L2300/163 , B01L2300/165 , B01L2300/168
摘要： The invention provides reduced background substrates, such as multi-well plates, for use in enzyme-linked immunosorbent assays (ELISAs) and other ligand-binding assays, and methods for making and using the same.
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3.发明授权公开(公告)号：US11667703B2
公开(公告)日：2023-06-06
申请号：US16830330
申请日：2020-03-26
申请人： Enzo Biochem, Inc.
发明人： Joshua Rabbani
CPC分类号： C07K16/22 , C07K14/47 , C07K14/51 , C07K14/705 , C07K14/71 , C07K16/44 , C07K2317/34
摘要： Provided are antibodies that bind to: a sulfonated epitope of the protein Sclerostin, to Sclerostin portions comprising a sulfonated amino acid and to dimerized forms of Sclerostin. Further provided are compositions and peptides comprising a sulfonated epitope of sclerostin. Also provided by this invention are methods for production of such antibodies, both active and passive, and methods for identifying antibodies specific for sulfonation sites in Sclerostin and other antibodies which discriminate between sulfonated and unsulfonated forms of sclerostin. Physical and virtual screening processes are provided in this invention for identifying compounds which disrupt or inhibit sulfonation and the interaction between Sclerostin and binding partners. The antibodies and compositions of the present invention are useful in diagnostic and therapeutic applications directed to Sclerostin-related disorders.
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公开(公告)号：US11639382B2
公开(公告)日：2023-05-02
申请号：US17130049
申请日：2020-12-22
申请人： Enzo Biochem, Inc.
发明人： Joshua Rabbani , James J. Donegan
IPC分类号： C07K16/22 , C07K14/47 , C07K14/51 , C07K14/705 , C07K14/71
摘要： Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a. In one embodiment, the Wnt pathway protein is the Dickkopf1 (Dkk1) protein. Further provided is a composition comprising a peptide less than 75 amino acids or amino acid analogs, the peptide consisting of a fragment of a Wnt pathway protein, such as a Dkk1, wherein the fragment is sulfated.
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公开(公告)号：US11554111B2
公开(公告)日：2023-01-17
申请号：US17197105
申请日：2021-03-10
申请人： Enzo Biochem, Inc.
发明人： Elazar Rabbani
IPC分类号： A61K31/4245 , A61K31/137
摘要： The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
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公开(公告)号：US20220025188A1
公开(公告)日：2022-01-27
申请号：US17363637
申请日：2021-06-30
申请人： Enzo Biochem, Inc.
发明人： Elazar Rabbani , Jack Coleman
摘要： The invention provides chemical conjugates comprising a plurality of fluorescence quenching moieties conjugated to polymer and the use of such conjugates to quench the emission of fluorescence from emitters including macromolecular fluorescent emitters such as phycoerythrin.
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公开(公告)号：US20220023402A1
公开(公告)日：2022-01-27
申请号：US17498834
申请日：2021-10-12
申请人： Enzo Biochem, Inc.
发明人： Robert Nussenblatt , Baoying Liu , Lai Wei , Elazar Rabbani , James J. Donegan
摘要： The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and one or more immune tolerance enhancers.
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公开(公告)号：US20210164017A1
公开(公告)日：2021-06-03
申请号：US17140257
申请日：2021-01-04
申请人： Enzo Biochem, Inc.
IPC分类号： C12Q1/6804 , G01N33/58 , C12Q1/6806 , C12Q1/6818 , C12Q1/6834 , G01N33/68 , G01N33/53
摘要： The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.
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公开(公告)号：US20210079225A1
公开(公告)日：2021-03-18
申请号：US17086514
申请日：2020-11-02
申请人： Enzo Biochem, Inc.
发明人： Zaiguo Li , Praveen Pande , Natarajan Raju
IPC分类号： C09B29/44 , C12Q1/68 , C12Q1/6818 , C12Q1/6844 , C09B56/00 , C12Q1/6876 , C12Q1/70
摘要： The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles. These dyes are essentially non-fluorescent but are efficient quenchers of various fluorescent dyes. Also, provided are methods of using the dyes, bio-probes incorporating dyes and methods of using the bio-probes. The quencher dyes described herein are modified to provide beneficial properties.
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公开(公告)号：US20200222341A1
公开(公告)日：2020-07-16
申请号：US16830357
申请日：2020-03-26
申请人： Enzo Biochem, Inc.
发明人： Elazar Rabbani , James J. Donegan
IPC分类号： A61K31/137 , A61K31/4245 , A61K45/06 , A61K31/135 , A61P35/00 , A61P35/02
摘要： The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
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