公开(公告)号：US12018303B2

公开(公告)日：2024-06-25

申请号：US16764476

申请日：2018-11-16

申请人： ENZYMICALS AG ,  UNIVERSITÄT ROSTOCK

发明人： Jan Von Langermann ,  Dennis Hülsewede ,  Marco Cornelius ,  Ulf Menyes ,  Philipp Süss

IPC分类号： C12P13/00 ,  C07C57/30 ,  C07C211/63 ,  C12P7/40

CPC分类号： C12P13/005 ,  C07C57/30 ,  C07C211/63 ,  C12P7/40

摘要： Described herein is a method for preparing an amino salt compound, the method including: i) providing a carbonyl compound; ii) reacting the carbonyl compound provided according to (i) in the presence of a transaminase with ii-a) at least one primary amine; and ii-b) at least one carboxylic acid; thereby obtaining a mixture including an at least partially crystallized amino salt compound including a cation and a carboxylate anion based on the at least one carboxylic acid added according to (ii-b). Also described herein is an amino salt compound obtained or obtainable by the method and to the amino salt compound, and a composition including a) an amine of general formula (IIa); and b) at least one carboxylic acid of general formula (III).

公开(公告)号：US20210155653A1

公开(公告)日：2021-05-27

申请号：US16625967

申请日：2018-06-21

申请人： Enzymicals AG

发明人： Ulf Menyes ,  Philipp Suss ,  Henrike Brundiek ,  Melinda Fekete

IPC分类号： C07J9/00 ,  C07J31/00 ,  C12P33/00

摘要： The present invention relates to a process for producing bile acid derivatives having a protected hydroxyl group in the 3 position comprising contacting a bile acid derivative having an unprotected 3-alpha-hydroxyl group with a specific lipase. The present invention further relates to a bile acid derivative obtained or obtainable by the process, to the use of the bile acid derivative obtained or obtainable by the process for producing lithocholic acid and also to a process for producing lithocholic acid and to lithocholic obtained by the process. The invention further relates to the use of lithocholic acid obtained or obtainable by the process for producing ursodeoxycholic acid or ursodeoxycholic acid derivatives.