摘要:
Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要:
The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases.
摘要:
A spinal cross-connector for connection between adjacent first and second rods and method for use of the same are disclosed. In one embodiment, a coupling member including a bar extends from a body portion opposite to and in longitudinal axial alignment with a c-shaped arm. A second coupling member which includes a rack extends from a body portion opposite to and in longitudinal axial alignment with a another c-shaped arm. The rack is superposed in a selectively adjustable overlapping mechanical engagement with the bearing surface. Each c-shaped arm includes an arcuate extension extending substantially parallel to the bar to define a gripping pocket. A set screw includes a conical profile that extends substantially perpendicular to the arcuate extension. The advance of the set screw is operable to urge the rod into pressing contact with the gripping pocket to secure the rod therein.
摘要:
An improved collapsible spreader with a spread rate selection mechanism including a knob and a rotatable cup-shaped structure. The cup-shaped structure includes an elongated setting tab and a thirty-six step edge corresponding to thirty-six spread rate settings on the knob. Operatively engaged with the cup-shaped structure is an abutment tab that is part of a closure structure for blocking and selectively unblocking a hopper opening. The tab engages the setting tab to define the adjustable length of the closure structure. Thereafter, abutment rate selection is a function of the rotatable position of the cup-shaped structure. Engagement of the abutment tab and a step defines the size of the hopper opening and thus the amount of product released from the hopper during operation. The spreader also includes a dual spring arrangement to bias the closure structure to a closed position and to prevent breakage. The disclosed spreader also features a one piece wheel to reduce parts and assembly costs.
摘要:
A spinal cross-connector for connection between adjacent first and second rods and method for use of the same are disclosed. In one embodiment, a coupling member including a bar extends from a body portion opposite to and in longitudinal axial alignment with a c-shaped arm. A second coupling member which includes a rack extends from a body portion opposite to and in longitudinal axial alignment with a another c-shaped arm. The rack is superposed in a selectively adjustable overlapping mechanical engagement with the bearing surface. Each c-shaped arm includes an arcuate extension extending substantially parallel to the bar to define a gripping pocket. A set screw includes a conical profile that extends substantially perpendicular to the arcuate extension. The advance of the set screw is operable to urge the rod into pressing contact with the gripping pocket to secure the rod therein.
摘要:
A pedicle screw fixation system and method for use of the same are disclosed. In one embodiment, a tulip is provided for holding a head of a pedicle screw substantially along a longitudinal axis. The tulip includes opposing first and second U-shaped receiving slots aligned along a transverse axis. A rod is received by the opposing first and second U-shaped receiving slots. A coupling collar includes a plurality of resilient fingers circumferentially disposed therearound such that a snap fit engagement with the head of the pedicle screw formed. The coupling collar includes a first deformable face operable for contact with the rod. A set screw is for adapted for driving engagement through the tulip along the longitudinal axis such that a second deformable face is positioned for contact with the rod. The first and second deformable faces conform to the shape of the rod in response to forceful engagement therewith.
摘要:
A bone plate and plating system are for use of the same are disclosed. The bone plate includes a body having a span sufficient to overlap a portion of a bone. A screw hole extends through the body in order to receive a bone screw to attach for engaging the plate to the bone. The screw hole includes a counterbore having a beveled surface that intersects at a pinch point a bore having a conical surface of revolution that transitions into the bone engaging surface of the body. The beveled surface includes a variable geometry defining interleaved and rotationally-spaced contact and non-contact bone screw regions.