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177 条记录 (耗时 0.023 秒)

    ((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides
    6.
    发明授权
    ((5,6-dichloro-3-oxo-9,9a-d isubstituted-2,3,9,9a-tetrahydrofluoren-7-yl)oxy)alkanoic acids and alkanimidamides 失效
    （（5,6-二氯-3-氧代-9,9a-二取代-2,3,9,9a-四氢芴-7-基）氧基）链烷酸和烷酰胺

    公开(公告)号：US4797391A

    公开(公告)日：1989-01-10

    申请号：US150462

    申请日：1988-02-08

    申请人： Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz

    发明人： Otto W. Woltersdorf, Jr. ,  Edward J. Cragoe, Jr. ,  Adolph M. Pietruszkiewicz

    IPC分类号： C07C49/755 ,  C07F9/24 ,  A61K31/645 ,  C07C129/12

    CPC分类号： C07C49/755 ,  C07F9/2466 ,  C07C2103/18

    摘要： The invention relates to novel [(5,6-dichloro-3-oxo-9,9a-disubstituted-2,3,9,9a-tetrahydro-fluoren-7-yl)oxy]alkanoic acids and alkanimidamides, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections, various brain concussions and elevated intracranial pressure.

    摘要翻译： 本发明涉及新的[（5,6-二氯-3-氧代-9,9a-二取代-2,3,9,9a-四氢 - 芴-7-基）氧]链烷酸和烷酰胺，其衍生物及其衍生物 盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，脑部感染引起的水肿，各种脑震荡和颅内压升高。

    Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema
    8.
    发明授权
    Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema 失效
    取代-3（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮用于治疗灰质水肿

    公开(公告)号：US4604403A

    公开(公告)日：1986-08-05

    申请号：US605734

    申请日：1984-05-01

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61P25/28 ,  C07D207/44 ,  C07D207/456 ,  C07D409/10

    CPC分类号： C07D207/456 ,  C07D409/10

    摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    Substituted [(2,3-dihydro-1-oxo-1H-inden-5-yl)amino]alkanoic acids, their derivatives and their salts
    9.
    发明授权
    Substituted [(2,3-dihydro-1-oxo-1H-inden-5-yl)amino]alkanoic acids, their derivatives and their salts 失效
    取代的[（2,3-二氢-1-氧代-1H-茚-5-基）氨基]链烷酸，其衍生物及其盐

    公开(公告)号：US4579869A

    公开(公告)日：1986-04-01

    申请号：US761949

    申请日：1985-08-02

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： A61K31/24 ,  C07C101/78 ,  A61K31/195

    CPC分类号： A61K31/24

    摘要： The invention relates to novel substituted [(2,3-dihydro-1-oxo-1H-inden-5-yl)amino]alkanoic acids, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代的[（2,3-二氢-1-氧代-1H-茚-5-基）氨基]链烷酸及其衍生物及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。