专利检索 ap:("Edward R. Bacon" OR "Thomas R. Bailey" OR "Nadine C. Becknell" OR "Sankar Chatterjee" OR "Derek Dunn" OR "Greg A. Hostetler" OR "Robert L. Hudkins" OR "Kurt A. Josef" OR "Lars J.S. Knutsen" OR "Ming Tao" OR "Alison L. Zulli") AND inv:"Ming Tao" 第 1 页

1.

发明申请
PYRIDAZINONE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物

公开(公告)号：US20140142088A1

公开(公告)日：2014-05-22

申请号：US14083013

申请日：2013-11-18

申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Alison L. Zulli

发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Alison L. Zulli

IPC分类号： C07D498/04 , C07D237/14 , C07D409/04 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D495/04

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.

摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意力缺陷多动障碍和认知。

2.

发明申请
Pyridazinone Derivatives 失效

公开(公告)号：US20100280007A1

公开(公告)日：2010-11-04

申请号：US12815800

申请日：2010-06-15

申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli

发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli

IPC分类号： A61K31/55 , A61K31/5377 , A61K31/502 , A61K31/501 , C07D413/12 , C07D498/04 , C07D403/12 , A61P25/00 , A61P3/04 , A61P25/28 , A61P25/18 , A61P25/08 , A61P11/00 , A61P25/24 , A61P29/00 , A61P9/10 , A61P1/00 , A61P25/06 , A61P43/00 , C07D495/04 , C07D401/14 , C07D409/14 , A61K31/5025

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.

3.

发明申请
Pyridazinone Derivatives 有权
标题翻译：哒嗪酮衍生物

公开(公告)号：US20110288075A1

公开(公告)日：2011-11-24

申请号：US13197243

申请日：2011-08-03

申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli

发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli

IPC分类号： A61K31/55 , A61K31/502 , A61K31/5025 , A61P25/00 , A61K31/50 , A61P25/28 , A61P25/18 , A61K31/501 , A61K31/5377

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.

摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意缺陷多动障碍和认知/认知障碍。

4.

发明申请
Pyridazinone Derivatives 有权
标题翻译：哒嗪酮衍生物

公开(公告)号：US20100273779A1

公开(公告)日：2010-10-28

申请号：US12815813

申请日：2010-06-15

申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli

发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli

IPC分类号： A61K31/55 , C07D403/12 , A61K31/501 , A61K31/502 , C07D495/04 , A61P3/04 , A61P9/10 , A61P11/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , A61P1/00 , A61P29/00

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.

摘要翻译： 本发明涉及介导酶活性的新型吡哒嗪酮衍生物。特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意力缺陷多动障碍和认知。

5.

发明授权
Aryl pyridazinone derivatives and their use as H3 receptor ligands 有权
标题翻译：芳基哒嗪酮衍生物及其用作H3受体配体

公开(公告)号：US08586588B2

公开(公告)日：2013-11-19

申请号：US12815813

申请日：2010-06-15

申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli

发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli

IPC分类号： C07D403/12 , C07D401/14 , A61K31/501 , A61P25/20 , A61P3/04 , A61P25/18 , A61P29/00 , A61P25/06 , A61P25/24 , A61P25/08

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds and/or their pharmaceutically acceptable salts may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.

摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。特别地，化合物和/或其药学上可接受的盐可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性障碍，睡眠/觉醒障碍，注意缺陷多动障碍和认知/认知障碍。

6.

发明授权
Methods of treating disorders mediated by histamine H3 receptors using pyridazinone derivatives 有权
标题翻译：使用哒嗪酮衍生物治疗由组胺H3受体介导的病症的方法

公开(公告)号：US08673916B2

公开(公告)日：2014-03-18

申请号：US13197243

申请日：2011-08-03

申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli

发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek D. Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli

IPC分类号： A61K31/501 , A61P3/04 , A61P25/28 , A61P25/18 , A61P25/08 , A61P25/06 , A61P25/24

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to methods of treating disorders mediated by Histamine H3 receptors by administering novel pyridazinone derivatives. In particular, the pyridazinone compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.

摘要翻译： 本发明涉及通过施用新的哒嗪酮衍生物治疗由组胺H3受体介导的病症的方法。特别地，哒嗪酮化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经退行性疾病，睡眠/觉醒障碍，注意缺陷多动障碍和认知/认知障碍。

7.

发明授权
Pyridizinone derivatives and the use thereof as H3 inhibitors 有权
标题翻译：吡啶并酮衍生物及其作为H3抑制剂的用途

公开(公告)号：US08247414B2

公开(公告)日：2012-08-21

申请号：US11881001

申请日：2007-07-25

申请人： Edward R. Bacon , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Robert L. Hudkins , Kurt A. Josef , Ming Tao , Allison L. Zulli

发明人： Edward R. Bacon , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Robert L. Hudkins , Kurt A. Josef , Ming Tao , Allison L. Zulli

IPC分类号： C07D401/14 , C07D237/26 , C07D498/04 , C07D237/36 , A61K31/501 , A61K31/502 , A61K31/5025 , C07D403/12 , C07D237/32 , C07D237/14 , C07D237/00 , C07D413/12 , A61K31/55 , A61K31/5355

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.

摘要翻译： 本发明涉及介导酶活性的新型吡哒嗪酮衍生物。特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意力缺陷多动障碍和认知。

8.

发明授权
Pyridazinone derivatives 失效
标题翻译：哒嗪酮衍生物

公开(公告)号：US08207168B2

公开(公告)日：2012-06-26

申请号：US12815800

申请日：2010-06-15

申请人： Nadine C. Becknell , Derek Dunn , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli

发明人： Nadine C. Becknell , Derek Dunn , Robert L. Hudkins , Kurt A. Josef , Lars J. S. Knutsen , Ming Tao , Allison L. Zulli

IPC分类号： A61K31/501 , A61K31/502 , C07D401/14 , C07D237/32 , C07D237/26 , C07D403/04 , A61P3/04 , A61P25/28 , A61P25/18 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/24 , A61P11/06 , A61P29/00 , A61P9/10

CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04

摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition disorders.

摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。特别地，所述化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经退行性疾病，睡眠/觉醒障碍，注意缺陷多动障碍和认知障碍。